Results 81 to 90 of about 19,342 (211)

THE EFFECT OF PRAZOSIN ON COMBAT RELATED POSTTRAUMATIC STRESS DISORDER NIGHTMARES

Journal of Research in Medical Sciences, 2003
Introduction: Several studies have shown noradrenergic system hyperactivity in posttraumatic stress disorder. Four Vietnam combat veterans with chronic PTSD, prescribed prazosin ?1 adrenergic receptor antagonist reported reduction or completely ...
G ASSADOUAHI, GH AHMADZADEH, J MAHMOUDI GHARAEI, N BASHARDOOST, T FAGHIHI   +4 more
doaj  

Progressive renal disease: Role of race and antihypertensive medications [PDF]

, 1935
Progressive renal disease: Role of race and antihypertensive medications. Hypertension is associated with an accelerated rate of decline in renal function in patients with chronic renal disease. To identify factors that might alter the rate of decline in
Peter C. Brazy, James F. Fitzwilliam, Lindeman, Mogensen, Brazy, McClellan, Rostand, Dustan, Stead, Mitch, Rutherford, Walser, Levy, Sowers, Levy, Anderson, Anderson, Mroczek, Mitchell, Schrier, Harris, Goligorsky, Harris, Gimenez, Eliahou, Walser, Laffel, Walker   +27 more
core   +1 more source

Comparison of Human and Canine P‐Glycoprotein Substrates at R, P, and H Binding Sites

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 2, Page 120-130, March 2026.
ABSTRACT P‐glycoprotein (P‐gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P‐gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P‐gp status of drugs intended for canine patients is equally, if not more, important.
Neal S. Burke, Katrina L. Mealey
wiley   +1 more source

Retrospective study of outcome in patients with scorpion sting using prazosin with/without dobutamine

Asian Journal of Medical Sciences, 2015
Introduction: Scorpion sting is a major public health problem in India with severe life threatening complications. Toxin can cause autonomic overstimulation leading to hypertension, arrhythmias and pulmonary edema with left ventricular dysfunction ...
L Venugopal
doaj   +1 more source

The role of dimerisation in the cellular trafficking of G-protein-coupled receptors [PDF]

, 2010
The concept that G-protein-coupled receptors can exist as homomeric and/or heteromeric complexes is now well established. Despite this, how dynamic such interactions are and if this may be modulated during receptor trafficking remain topics of debate ...
Milligan, Graeme
core   +1 more source

Role of S1P‐ and Rho‐kinase signalling in age‐related myogenic tone deficiency in murine resistance arteries

Experimental Physiology, Volume 111, Issue 3, Page 1524-1542, 1 March 2026.
Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I. Aldana, Hirotsugu Tsuchimochi, Mark T. Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen   +11 more
wiley   +1 more source

Rat pial microvascular responses to melatonin during bilateral common carotid artery occlusion and reperfusion [PDF]

, 2011
The present study assessed the in vivo rat pial microvascular responses induced by melatonin during brain hypoperfusion and reperfusion (RE) injury. Pial microcirculation of male Wistar rats was visualized by fluorescence microscopy through a closed ...
Cardaci E, COLANTUONI, ANTONIO, Lapi D, Paterni M, Vagnani S   +4 more
core   +1 more source

Effect of dynamic cerebral autoregulation of cerebral blood flow regulation during cold pressor test

Physiological Reports, Volume 14, Issue 5, March 2026.
Abstract The cold pressor test (CPT) is a clinical stress test commonly used to evoke acute pressor and respiratory responses, accompanied by increased sympathetic nerve activity. Cerebral blood flow (CBF) is well‐preserved during CPT despite elevated arterial blood pressure (ABP), but the underlying mechanisms remain unclear.
Shigehiko Ogoh, Kanoko Ito, Megumi Kaji, Narumi Kunimatsu, Kinu Tatsuta, Manabu Shibasaki   +5 more
wiley   +1 more source

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo   +10 more
wiley   +1 more source

Propranolol and Prazosin Have a Positive Effect on the Sexual Performance of Female Three-Spot Gourami [PDF]

Journal of Kerman University of Medical Sciences
Background: Sexual function is one of the most important aspects of life and is likely to be affected by the side effects of antihypertensive drugs. This study aimed to evaluate the effect of propranolol and prazosin on the sexual performance of female ...
Marzieh Monemi, Tahereh Naji, Afshin Kheradmand   +2 more
doaj   +1 more source