Results 51 to 60 of about 28,463 (245)
Sleep Medicine, 2019 Nightmares are a highly prevalent and distressing feature of post-traumatic stress disorder (PTSD). Previous studies have reached mixed conclusions regarding the effects of prazosin on nightmares, sleep quality and overall PTSD symptoms in patients with ...
Ye Zhang +10 more
semanticscholar +1 more source
Systematic Reviews, 2017 Background Scorpion stings cause an estimated 3000 deaths per annum worldwide. We conducted a systematic review of all controlled clinical trials related to scorpion sting management.
Chaturaka Rodrigo, Ariaranee Gnanathasan
doaj +1 more source
American Journal of Psychiatry, 2018 Background: Current medications for alcohol use disorder do not target brain noradrenergic pathways. Theoretical and preclinical evidence suggest that noradrenergic circuits may be involved in alcohol reinforcement and relapse. Following a positive pilot
Tracy L. Simpson +7 more
semanticscholar +1 more source
Journal of addiction medicine, 2018 Objectives: The noradrenergic system plays an important role in the pathophysiology of alcohol use disorder (AUD). Medications in this class may reduce drinking. Our aims were to investigate this in a unique sample of individuals with AUD.
Claire E. Wilcox +5 more
semanticscholar +1 more source
Sleep disturbances and nightmares in a patient treated with prazosin [PDF]
, 2016 Prazosin is increasingly being used off-label to treat nightmares in patients with posttraumatic stress disorder. The literature about the psychiatric adverse effects of prazosin is very limited.
KOSARI, Sam, NAUNTON, Mark
core +1 more source
Prazosin during fear conditioning facilitates subsequent extinction in male C57Bl/6N mice
Psychopharmacology, 2018 Recovery from a traumatic experience requires extinction of cue-based fear responses, a process that is impaired in post-traumatic stress disorder. While studies suggest a link between fear behavioral flexibility and noradrenaline signaling, the role of ...
E. Lucas +3 more
semanticscholar +1 more source
Differential alpha1-adrenoceptor labeling by [3H]prazosin and [3H]tamsulosin [PDF]
, 1998 The radioligand binding properties of [3H]prazosin and [3H]tamsulosin at alpha1-adrenoceptors of several rat tissues, human prostate and cloned rat and human alpha1-adrenoceptor subtypes were compared in Tris/EDTA buffer unless otherwise indicated.
Goepel, M., Michel, M. C.
core +1 more source
Neurological Therapeutics, 2017 IntroductionYouth exposed to trauma have an increased risk for developing posttraumatic stress disorder (PTSD) and associated sleep disturbances and nightmares. The alpha-1 antagonist prazosin reduces sleep disturbances and nightmares in adults with PTSD;
B. Keeshin +4 more
semanticscholar +1 more source
Molecules, 2015 Novel and promising macromolecular conjugates of the α1-adrenergic blocker prazosin were directly synthesized by covalent incorporation of the drug to matrices composed of biodegradable polymers and α-amino acids for the development of a polymeric ...
Ewa Oledzka +5 more
doaj +1 more source
Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies
Advanced Science, EarlyView.This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang +7 more
wiley +1 more source