Results 51 to 60 of about 19,342 (211)

Quercetin Is a Flavonoid Breast Cancer Resistance Protein Inhibitor with an Impact on the Oral Pharmacokinetics of Sulfasalazine in Rats

Pharmaceutics, 2020
The potential inhibitory effect of quercetin, a major plant flavonol, on breast cancer resistance protein (BCRP) activity was investigated in this study.
Yoo-Kyung Song, Jin-Ha Yoon, Jong Kyu Woo, Ju-Hee Kang, Kyeong-Ryoon Lee, Seung Hyun Oh, Suk-Jae Chung, Han-Joo Maeng   +7 more
doaj   +1 more source

A non-randomized pilot trial of the use of prazosin in the prevention of transition from acute stress disorder to post-traumatic stress disorder

European Journal of Psychotraumatology, 2023
Background: Following a traumatic event, 40–80% of the patients with acute stress disorder (ASD) will develop post-traumatic stress disorder (PTSD), 67% at 6 months.
Charline Magnin, Emmanuel Poulet, Laurent Fanton, Philippe Vignaud, Jerome Brunelin   +4 more
doaj   +1 more source

A systematic review of performance-enhancing pharmacologicals and biotechnologies in the Army [PDF]

, 2018
INTRODUCTION: In 2015, the Australian Army commissioned a systematic review to assess the evidence on effectiveness and safety of pharmacological and biotechnological products for cognitive enhancement specifically in Army personnel.METHODS: Searches for
Ayson, Mark, Hunter, K E, Ko, Henry, Scott, A M, Willson, M L   +4 more
core   +1 more source

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, EarlyView.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source

Physiological markers of Trauma‐related nightmares among military personnel suffering from PTSD: A multicenter home‐recording study

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Despite being one of the most disabling symptoms of post‐traumatic stress disorder (PTSD)—disrupting sleep continuity, reinforcing hyperarousal, and worsening psychiatric comorbidity—the physiological signature of Trauma‐related nightmares (TRNs) under naturalistic sleep conditions remains poorly characterized.
Dorone Feingold, Michael Quiquempoix, Marion Remadi, Gilles Sipahimalani, Bertrand Lahutte, Damien Léger, Danielle Gomez‐Merino, Mounir Chennaoui, Emeric Saguin   +8 more
wiley   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source

Optimizing Aggregated N-Of-1 Trial Designs for Predictive Biomarker Validation: Statistical Methods and Theoretical Findings

Frontiers in Digital Health, 2020
Background and Significance: Parallel-group randomized controlled trials (PG-RCTs) are the gold standard for detecting differences in mean improvement across treatment conditions.
Rebecca C. Hendrickson, Rebecca C. Hendrickson, Ronald G. Thomas, Nicholas J. Schork, Nicholas J. Schork, Murray A. Raskind, Murray A. Raskind   +6 more
doaj   +1 more source

Electronic medical records-based retrospective, longitudinal, observational study to understand the patient management of benign prostatic hyperplasia with alpha-blockers monotherapy in Indian population

Urology Annals, 2023
Objective: The present retrospective study evaluates the effectiveness and tolerability of alpha-blockers as monotherapy in patients with benign prostatic hyperplasia associated with lower urinary tract symptoms (LUTS).
Rahul Gupta, Sameer Trivedi, Surya Prakash Vaddi, Mrinal Borgohain, Rajan Mittal, Sucheta Pandit, Amey Mane   +6 more
doaj   +1 more source

A Feasibility Study of the Repurposing of Prazosin to Improve Treatment Outcomes in Men Receiving Radiotherapy for Prostate Cancer (MiniRaP‐00)

The Prostate, Volume 86, Issue 8, Page 891-899, June 2026.
ABSTRACT Background Further work is needed to improve treatment outcomes for prostate cancer (PCa), with the repurposing of the α1‐adrenoreceptor antagonists presenting a potential solution. This feasibility clinical trial presents the first prospective data of the use of an α1‐adrenoreceptor antagonist in men undergoing radiotherapy for PCa.
Liam D. King, David Christie, Daniel Cehic, Wendy Dare, Russ Chess‐Williams, Donna Sellers, Catherine McDermott, Alexandra McCarthy, Shailendra Anoopkumar‐Dukie   +8 more
wiley   +1 more source

Efficacy of scorpion antivenom plus prazosin compared with prazosin alone for scorpion sting in children: A cross sectional study [PDF]

Al Ameen Journal of Medical Sciences
Background: Scorpion sting can pose as a life threatening acute medical emergency, which, if not attended to on an emergency basis can result in mortality. Scorpion venoms are a composed of a complex mixture of proteins.
R. Nagarjun, Pooja G. Manoli, A. Ashoka
doaj