Results 151 to 160 of about 270,676 (398)
Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus
Advanced Science, EarlyView.This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu +9 more
wiley +1 more source
Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. [PDF]
, 1993 Akila Mayeda +2 more
openalex +3 more sources
PLoS ONE, 2012 Spatially and temporally controlled gene expression, including transcription, several mRNA processing steps, and the export of mature mRNA to the cytoplasm, is essential for developmental processes.
Shunya Hozumi +8 more
doaj +1 more source
Assembly of pre-mRNA splicing complex is cap dependent [PDF]
, 1987 Erik Patzelt +4 more
openalex +1 more source
Advanced Science, EarlyView.This study investigates the role of group 2 innate lymphoid cells (ILC2) in the choroid plexus (ChP) following traumatic brain injury (TBI). ILC2 accumulation alleviates immune infiltration, preserves hippocampal integrity, and improves sensory‐motor and memory functions.
Shiqi Gao +10 more
wiley +1 more source
A novel role for the 3' region of introns in pre-mRNA splicing of Saccharomyces cerevisiae. [PDF]
, 1987 Brian C. Rymond +2 more
openalex +1 more source
Advanced Science, EarlyView.This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao +7 more
wiley +1 more source
The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages
Cell Reports, 2019 Summary: While transcriptional control of innate immune gene expression is well characterized, almost nothing is known about how pre-mRNA splicing decisions influence, or are influenced by, macrophage activation.
Kelsi O. West +5 more
doaj
Identified five variants in CFTR gene that alter RNA splicing by minigene assay
Frontiers in GeneticsBackgroundCystic fibrosis (CF) is a common monogenic multisystem disease caused primarily by variants in the CFTR gene. Emerging evidence suggests that some variants, which are described as missense, synonymous or nonsense variants in the literature or ...
Bingying Zhang +9 more
doaj +1 more source
AtUBL5 regulates growth and development through pre-mRNA splicing in Arabidopsis thaliana.
PLoS ONE, 2019 Ubiquitin-like proteins play important roles in the regulation of many biological processes. UBL5 (Ubiquitin-like protein 5)/Hub1 (Homologous to ubiquitin 1), a member of the ubiquitin family, acts as a ubiquitin-like modifier on a specific target, the ...
Etsuko Watanabe +3 more
doaj +1 more source