Results 161 to 170 of about 106,307 (216)

SRSF10 regulates oligodendrocyte differentiation during mouse central nervous system development by modulating pre-mRNA splicing. [PDF]

Nucleic Acids Res
Mu Y, Wei Z, Sun M, Li J, Jiang Y, Jiang H, Ma A, Zhu C, Chen X.   +8 more
europepmc   +1 more source

The Differing Phenotypes of the Three Most Common Postsynaptic Congenital Myasthenic Syndromes Governed by Their Underlying Molecular Pathogenic Mechanisms

Muscle &Nerve, EarlyView.
ABSTRACT The congenital myasthenic syndromes are rare disorders of impaired signal transmission at the neuromuscular junction. Despite next generation sequencing facilitating the identification of variants in myasthenic‐associated genes, these variants are frequently of unknown significance and the clinical diagnosis can be delayed.
David Beeson
wiley   +1 more source

RNPS1 in PSAP complex controls periodic pre-mRNA splicing over the cell cycle. [PDF]

iScience
Fukumura K, Masuda A, Takeda JI, Nagano O, Saya H, Ohno K, Mayeda A.   +6 more
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules. [PDF]

Genes Dev
Peyda P, Lin CH, Onwuzurike K, Black DL.
europepmc   +1 more source

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

Pre-mRNA splicing modulates post-harvest deterioration of cassava storage root. [PDF]

Plant Physiol
Ku YS.
europepmc   +1 more source

Transcriptomic resources and functional validation of RNAi in the cabbage seedpod weevil, Ceutorhynchus obstrictus

Pest Management Science, EarlyView.
Transcriptome sequencing of Ceutorhynchus obstrictus revealed RNA interference (RNAi) targets; double‐stranded RNA microinjection reduced transcript levels and increased mortality, with αCOP and Rop showing strongest lethal effects, indicating promising RNAi‐based pest control candidates.
Apurva Vikas Sabnis, Triin Kallavus, Éricmar Avila Dos Santos, Liina Soonvald, Riina Kaasik, Silva Vilumets, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +8 more
wiley   +1 more source

Mechanisms and regulation of spliceosome-mediated pre-mRNA splicing in Saccharomyces cerevisiae. [PDF]

Wiley Interdiscip Rev RNA
Senn KA, Hoskins AA.
europepmc   +1 more source