Results 181 to 190 of about 127,514 (315)

CDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing. [PDF]

Nucleic Acids Res
Rájecký M, Gajdušková P, Maník P, Hluchý M, Hegedűsová E, Kryštofová K, Potěšil D, Martinková P, Slabá Z, Khirsariya P, Šebesta M, Paruch K, Friedel CC, Zdráhal Z, Blazek D.   +14 more
europepmc   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Competition for the conserved branch point sequence influences physiological outcomes in pre-mRNA splicing. [PDF]

Elife
Pereira de Castro KL, Abril JM, Liao KC, Hao H, Donohue JP, Russell WK, Fagg WS.   +6 more
europepmc   +1 more source

CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing. [PDF]

EMBO J, 2023
Wang C, Xu L, Du C, Yun H, Wang K, Liu H, Ye M, Fan J, Zhou Y, Cheng H.   +9 more
europepmc   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK. [PDF]

Proc Natl Acad Sci U S A
Lee A, Gentzler A, Fitzpatrick D, Raju Ponny S, Aydemir O, Han MS, Lewis CA, Gao G, Davis RJ.   +8 more
europepmc   +1 more source

Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches

Chemistry – A European Journal, EarlyView.
We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal, Hugo Laigle, Maxime Mansy, Sébastien Ulrich, Mathieu Surin   +4 more
wiley   +1 more source

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators. [PDF]

ACS Chem Biol
Love SL, Vollmer H, Chang YC, Paulson JC, Carrocci TJ, Jurica MS, Nguyen HD, Hoskins AA.   +7 more
europepmc   +1 more source

Pre-mRNA splicing and its cotranscriptional connections. [PDF]

Trends Genet, 2023
Shenasa H, Bentley DL.
europepmc   +1 more source