Results 181 to 190 of about 205,219 (310)

HSV ICP27 hijacks host splicing factor SRSF3 to regulate pre-mRNA splicing and export for viral gene expression and immune evasion. [PDF]

PLoS Pathog
Tang S, Patel A, Takeda K, Peden K, Krause PR.   +4 more
europepmc   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam, Sushmitha Sriramulu, Asya Haider Muratoglu, Stephen Brown, Oudai Hassan, Benjamin Movsas, Haythem Ali, Steven Chang, Patrick Ha, Farzan Siddiqui, Shyam Nyati   +10 more
wiley   +1 more source

The pre-mRNA splicing factor ZOP1 contributes to the regulation of plant immunity. [PDF]

Plant Physiol
Wang Y, Huang W, Zhang P, Li X, Zhang Y.
europepmc   +1 more source

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, EarlyView.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source

An SpC editor targeting pre-mRNA splicing for precise CRISPR control and enhanced antitumor efficacy. [PDF]

Nucleic Acids Res
Shi X, Hu C, Jia L, Lei Z, Guo B, Zhou J, Wang F.   +6 more
europepmc   +1 more source

Microsatellite Instability and Aberrant Pre-mRNA Splicing: How Intimate Is It? [PDF]

Genes (Basel), 2023
Corcos L, Le Scanf E, Quéré G, Arzur D, Cueff G, Jossic-Corcos CL, Le Maréchal C.   +6 more
europepmc   +1 more source

Substrate Characterization of Mycobacterial Kinase PknG Revealing PknG‐KARS‐MAPK Phosphorylation Signaling Axis in Host

iMetaMed, EarlyView.
This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian, Shuyu Xie, Yanqing Tang, Junjie Liang, Wenhan Zhu, Tianqi Liu, Yewen Sun, Yang Yang, Luoxi Zhang, Danfeng Wang, Chuyao Lin, Jinyu Jia, Minjia Tan, Jun‐Yu Xu   +13 more
wiley   +1 more source

Correction: TTK promotes mitophagy by regulating ULK1 phosphorylation and pre-mRNA splicing to inhibit mitochondrial apoptosis in bladder cancer. [PDF]

Cell Death Differ
Chen K, Chen J, Cong Y, He Q, Liu C, Chen J, Li H, Ju Y, Chen L, Song Y, Xing Y.   +10 more
europepmc   +1 more source

The problem of selection bias in studies of pre-mRNA splicing. [PDF]

Nat Commun, 2023
Dwyer ZW, Pleiss JA.
europepmc   +1 more source