Results 171 to 180 of about 205,219 (310)

Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK. [PDF]

Proc Natl Acad Sci U S A
Lee A, Gentzler A, Fitzpatrick D, Raju Ponny S, Aydemir O, Han MS, Lewis CA, Gao G, Davis RJ.   +8 more
europepmc   +1 more source

Pre-mRNA splicing and its cotranscriptional connections. [PDF]

Trends Genet, 2023
Shenasa H, Bentley DL.
europepmc   +1 more source

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

The role of alternative pre-mRNA splicing in cancer progression. [PDF]

Cancer Cell Int, 2023
Choi S, Cho N, Kim EM, Kim KK.
europepmc   +1 more source

Alternative Splicing and Polyadenylation Contribute to the Generation of hERG1 C-terminal Isoforms

, 2010
The human ether-a-go-go-related gene 1 (hERG1) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel. Several hERG1 isoforms with different N- and C-terminal ends have been identified.
Gong, Qiuming, Stump, Matthew R., Dunn, A. Russell, Deng, Vivianne, Zhou, Zhengfeng   +4 more
core  

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators. [PDF]

ACS Chem Biol
Love SL, Vollmer H, Chang YC, Paulson JC, Carrocci TJ, Jurica MS, Nguyen HD, Hoskins AA.   +7 more
europepmc   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Decoding retinitis pigmentosa: molecular targets and therapy with focus on pre-mRNA splicing. [PDF]

Cell Mol Life Sci
Banik P, Staněk D.
europepmc   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source