Role of the branch site/3'-splice site region in adenovirus-2 E1A pre-mRNA alternative splicing: evidence for 5'- and 3'-splice site co-operation [PDF]
Per Johan Ulfendahl+2 more
openalex +1 more source
In SETD2‐mutant ccRCC, the original LEDGF recognition of the H3K36me3 regulatory axis no longer exists. LEDGF interacts with CARM1‐dependent H3R17me2a regulating the transcription of key enzymes in the de novo synthesis pathway. The abnormally elevated LEDGF leads to the accumulation of purine nucleotides in SETD2‐mutant ccRCC, thereby satisfying the ...
Yuwei Zhang+11 more
wiley +1 more source
Structure of a pre-mRNA branch point/3' splice site region. [PDF]
Kathleen B. Hall+2 more
openalex +1 more source
Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos
This study performs a comprehensive single‐cell transcriptome analysis of sheep embryos from embryonic (E) day 1 to E14 to elucidate the mechanism of early lineage specification and the pluripotency changes (naïve, formative, and primed) of epiblast.
Jinying Zhang+28 more
wiley +1 more source
U1 small nuclear RNAs with altered specificity can be stably expressed in mammalian cells and promote permanent changes in pre-mRNA splicing. [PDF]
Justus B. Cohen+2 more
openalex +2 more sources
Plant small nuclear RNAs. IV. The structure of U1 RNA fromChlorella saccharophila: a phylogenetic support, in terms of RNA structure, for the probable interaction between U1 and U2 and RNPs during the splicing of pre-mRNA [PDF]
Tamás Kiss+3 more
openalex +1 more source
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu+4 more
wiley +1 more source
MicroRNA miR-1002 Enhances NMNAT-Mediated Stress Response by Modulating Alternative Splicing
Summary: Understanding endogenous regulation of stress resistance and homeostasis maintenance is critical to developing neuroprotective therapies. Nicotinamide mononucleotide adenylyltransferase (NMNAT) is a conserved essential enzyme that confers ...
Joun Park+6 more
doaj
Identification of proteins that bind tightly to pre-mRNA during in vitro splicing. [PDF]
Sandra H. Mayrand+2 more
openalex +1 more source