Results 171 to 180 of about 270,676 (398)

Single‐Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Advanced Science, EarlyView.
This study uses single‐nucleus RNA sequencing and spatial transcriptomics to investigate penile squamous cell carcinoma (PSCC). It reveals that PSCC tumor cells mimic normal penile epithelium differentiation, independent of HPV status. The Tum_1 subtype shows basal stem‐like characteristics and promotes invasiveness. HPV‐positive basal stem‐like tumors
Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu   +37 more
wiley   +1 more source

Classification of DNA Sequences by Hayashi’s Quantification (III) Method. Sequences Involving 5′-Splice Signals in Pre-mRNA of Higher Eukaryotes’ Genes [PDF]

, 1988
Yôichi Iida
openalex   +1 more source

Organization of the Proteostasis Network of Membraneless Organelles

Advanced Science, EarlyView.
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim, Yuqi Bian, Alicia González Díaz, Frank Pun, Alex Zhavoronkov, Richard I. Morimoto, Michele Vendruscolo   +6 more
wiley   +1 more source

Analysis of in situ pre-mRNA targets of human splicing factor SF1 reveals a function in alternative splicing [PDF]

, 2017
The conserved pre-mRNA splicing factor SF1 is implicated in 3′ splice site recognition by binding directly to the intron branch site. However, because SF1 is not essential for constitutive splicing, its role in pre-mRNA processing has remained mysterious.
Antih, Nicolas, Corioni, Margherita, Krämer, Angela, Tanackovic, Goranka, Zavolan, Mihaela   +4 more
core  

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing.

Molecules and Cells, 2007
E. Makeyev, Jiangwen Zhang, M. Carrasco, T. Maniatis   +3 more
semanticscholar   +1 more source

A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma

Advanced Science, EarlyView.
This study utilizes patient‐derived osteosarcoma organoids and CRISPR screening to identify ERCC6 and HNRNPM as key mediators of cisplatin resistance via the PI3K/AKT pathway and BAX alternative splicing. These findings provide novel insights and potential therapeutic targets for overcoming chemoresistance in osteosarcoma.
Ruiling Xu, Sai Zhu, Wenchao Zhang, Haodong Xu, Chao Tu, Honghui Wang, Lu Wang, Na He, Tang Liu, Xiaoning Guo, Xiaolei Ren, Zhihong Li   +11 more
wiley   +1 more source

CDK11 requires a critical activator SAP30BP to regulate pre-mRNA splicing. [PDF]

EMBO J, 2023
Wang C, Xu L, Du C, Yun H, Wang K, Liu H, Ye M, Fan J, Zhou Y, Cheng H.   +9 more
europepmc   +1 more source

Regulated tissue-specific expression of antagonistic pre-mRNA splicing factors [PDF]

, 1998
The SR proteins are essential metazoan pre-mRNA splicing factors that can also influence the selection of alternative 5' splice sites in a concentration-dependent manner.
Caceres, J. F., Franza, B. R., Hanamura, A., Krainer, A. R., Mayeda, A.   +4 more
core   +1 more source

A common pyrimidine-rich motif governs trans-splicing and polyadenylation of tubulin polycistronic pre-mRNA in trypanosomes. [PDF]

, 1994
Keith R. Matthews, Christian Tschudi, E Ullu   +2 more
openalex   +1 more source