Results 11 to 20 of about 270,676 (398)
Pre-mRNA splicing and human disease. [PDF]
Genes & Development, 2003 The precision and complexity of intron removal during pre-mRNA splicing still amazes even 26 years after the discovery that the coding information of metazoan genes is interrupted by introns (Berget et al. 1977; Chow et al. 1977).
N. Faustino, T. Cooper
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Pre-mRNA splicing: awash in a sea of proteins. [PDF]
Molecular Cell, 2003 What's in a spliceosome? More than we ever imagined, according to recent reports employing proteomics techniques to analyze this multi-megadalton machine. As of 1999, around 100 splicing factors were identified (Burge et al., 1999); however, that number has now nearly doubled due primarily to improved purification of spliceosomes coupled with advances ...
M. Jurica, M. Moore
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Epigenetics in Alternative Pre-mRNA Splicing [PDF]
Cell, 2011 Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin
R. Luco +4 more
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A coactivator of pre-mRNA splicing [PDF]
Genes & Development, 1998 The nuclear matrix antigen recognized by the monoclonal antibody (mAb) B1C8 is a novel serine (S) and arginine (R)-rich protein associated with splicing complexes and is named here SRm160 (SR-related matrix protein of 160 kD). SRm160 contains multiple SR repeats, but unlike proteins of the SR family of splicing factors, lacks an RNA recognition motif ...
Jeffrey A. Nickerson +3 more
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Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages
G3: Genes, Genomes, Genetics, 2020 Alveolar macrophages serve as central orchestrators of inflammatory responses in the lungs, both initiating their onset and promoting their resolution. However, the mechanisms that program macrophages for these dynamic responses are not fully understood.
William J. Janssen +8 more
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Environmental Stress and Pre-mRNA Splicing [PDF]
Molecular Plant, 2015 Pre-mRNA splicing is an important step for gene expression regulation in plants in response to abiotic stress. In recent years, RNA sequencing (RNA-seq) based on various next-generation sequencing technologies has been used to study dynamic changes of pre-mRNA splicing under conditions of diverse abiotic stress in several plant species.
Cui, Peng, Xiong, Liming
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Embracing the complexity of pre-mRNA splicing [PDF]
Cell Research, 2010 NIH Public Access Author Manuscript Cell Res. Author manuscript; available in PMC 2014 February 03. NIH-PA Author Manuscript Published in final edited form as: Cell Res. 2010 August ; 20(8): 866–868. doi:10.1038/cr.2010.98. Embracing the Complexity of Pre-mRNA Splicing Peter J. Shepard and Klemens J.
Shepard, Peter J, Hertel, Klemens J
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Pre-mRNA secondary structures influence exon recognition. [PDF]
PLoS Genetics, 2007 The secondary structure of a pre-mRNA influences a number of processing steps including alternative splicing. Since most splicing regulatory proteins bind to single-stranded RNA, the sequestration of RNA into double strands could prevent their binding ...
Michael Hiller +3 more
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Pre-mRNA Splicing in the Nuclear Landscape [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2019 Eukaryotic gene expression requires the cumulative activity of multiple molecular machines to synthesize and process newly transcribed pre-messenger RNA. Introns, the noncoding regions in pre-mRNA, must be removed by the spliceosome, which assembles on the pre-mRNA as it is transcribed by RNA polymerase II (Pol II).
Karla M. Neugebauer, Tucker J. Carrocci
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Splice site m6A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma [PDF]
PeerJ, 2023 Oral squamous cell carcinoma (OSCC) is the 11th most prevalent tumor worldwide. Despite advantages of therapeutic approaches, the 5-year survival rate of patients with OSCC is less than 50%.
Xiaoxu Li +5 more
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