Results 11 to 20 of about 211,616 (238)
Environmental Stress and Pre-mRNA Splicing [PDF]
Molecular Plant, 2015 Pre-mRNA splicing is an important step for gene expression regulation in plants in response to abiotic stress. In recent years, RNA sequencing (RNA-seq) based on various next-generation sequencing technologies has been used to study dynamic changes of pre-mRNA splicing under conditions of diverse abiotic stress in several plant species.
Peng Cui, Liming Xiong
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Inflammation-Induced Alternative Pre-mRNA Splicing in Mouse Alveolar Macrophages
G3: Genes, Genomes, Genetics, 2020 Alveolar macrophages serve as central orchestrators of inflammatory responses in the lungs, both initiating their onset and promoting their resolution. However, the mechanisms that program macrophages for these dynamic responses are not fully understood.
William J. Janssen +8 more
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Pre-mRNA secondary structures influence exon recognition. [PDF]
PLoS Genetics, 2007 The secondary structure of a pre-mRNA influences a number of processing steps including alternative splicing. Since most splicing regulatory proteins bind to single-stranded RNA, the sequestration of RNA into double strands could prevent their binding ...
Michael Hiller +3 more
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Splice site m6A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma [PDF]
PeerJ, 2023 Oral squamous cell carcinoma (OSCC) is the 11th most prevalent tumor worldwide. Despite advantages of therapeutic approaches, the 5-year survival rate of patients with OSCC is less than 50%.
Xiaoxu Li +5 more
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RNA catalyses nuclear pre-mRNA splicing [PDF]
Nature, 2013 In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a dynamic machine composed of both proteins and small nuclear RNAs (snRNAs). Over thirty years ago, after the discovery of self-splicing group II intron RNAs, the snRNAs were proposed to catalyse splicing.
Fica, Sebastian M. +8 more
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Neurobiology of Disease, 2007 Several ubiquitously expressed genes encoding pre-mRNA splicing factors have been associated with autosomal dominant retinitis pigmentosa (adRP), including PRPF31, PRPF3 and PRPF8.
Daniel Mordes +5 more
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SAM68 is a physiological regulator of SMN2 splicing in spinal muscular atrophy [PDF]
, 2015 Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by loss of motor neurons in patients with null mutations in the SMN1 gene. The almost identical SMN2 gene is unable to compensate for this deficiency because of the skipping of exon 7 ...
Annalisa Nobili +51 more
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Genome Biology, 2018 Understanding the functional impact of genomic variants is a major goal of modern genetics and personalized medicine. Although many synonymous and non-coding variants act through altering the efficiency of pre-mRNA splicing, it is difficult to predict ...
Scott I. Adamson +2 more
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Identification of small molecule inhibitors of pre-mRNA splicing [PDF]
, 2014 Background: There is a need for new small molecule pre-mRNA splicing inhibitors as biotools. Results: High throughput screening resulted in the identification of small molecule splicing inhibitors that are active in vitro and in cells.
Gray, David +8 more
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The Drosophila splicing factor PSI is phosphorylated by casein kinase II and tousled-like kinase. [PDF]
PLoS ONE, 2013 Alternative splicing of pre-mRNA is a highly regulated process that allows cells to change their genetic informational output. These changes are mediated by protein factors that directly bind specific pre-mRNA sequences.
J Matthew Taliaferro +6 more
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