Results 11 to 20 of about 127,514 (315)
Embracing the complexity of pre-mRNA splicing [PDF]
Cell Research, 2010 NIH Public Access Author Manuscript Cell Res. Author manuscript; available in PMC 2014 February 03. NIH-PA Author Manuscript Published in final edited form as: Cell Res. 2010 August ; 20(8): 866–868. doi:10.1038/cr.2010.98. Embracing the Complexity of Pre-mRNA Splicing Peter J. Shepard and Klemens J.
Shepard, Peter J, Hertel, Klemens J
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RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility. [PDF]
PLoS Genetics, 2013 Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity.
Moira K O'Bryan +11 more
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Pre-mRNA splicing and human disease [PDF]
Genes & Development, 2003 The precision and complexity of intron removal during pre-mRNA splicing still amazes even 26 years after the discovery that the coding information of metazoan genes is interrupted by introns (Berget et al. 1977; Chow et al. 1977). Adding to this amazement is the recent realization that most human genes express more than one mRNA by alternative splicing,
Nuno André, Faustino, Thomas A, Cooper
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Neurobiology of Disease, 2007 Several ubiquitously expressed genes encoding pre-mRNA splicing factors have been associated with autosomal dominant retinitis pigmentosa (adRP), including PRPF31, PRPF3 and PRPF8.
Daniel Mordes +5 more
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Regulation of alternative pre-mRNA splicing [PDF]
Briefings in Functional Genomics and Proteomics, 2002 The first wave of bioinformatic studies that followed genome and complementary DNA sequencing projects revealed that alternative splicing of messenger RNA precursors (pre-mRNAs) contributes substantially to transcriptome complexity in higher eukaryotes.
Louise, Woodley, Juan, Valcárcel
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Quantification of pre-mRNA escape rate and synergy in splicing [PDF]
, 2014 Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape the nucleus with a retained intron. Intron retention can control gene expression and increase proteome diversity.
Becskei, Attila +13 more
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Genome Biology, 2018 Understanding the functional impact of genomic variants is a major goal of modern genetics and personalized medicine. Although many synonymous and non-coding variants act through altering the efficiency of pre-mRNA splicing, it is difficult to predict ...
Scott I. Adamson +2 more
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The Drosophila splicing factor PSI is phosphorylated by casein kinase II and tousled-like kinase. [PDF]
PLoS ONE, 2013 Alternative splicing of pre-mRNA is a highly regulated process that allows cells to change their genetic informational output. These changes are mediated by protein factors that directly bind specific pre-mRNA sequences.
J Matthew Taliaferro +6 more
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Environmental Stress and Pre-mRNA Splicing [PDF]
Molecular Plant, 2015 Pre-mRNA splicing is an important step for gene expression regulation in plants in response to abiotic stress. In recent years, RNA sequencing (RNA-seq) based on various next-generation sequencing technologies has been used to study dynamic changes of pre-mRNA splicing under conditions of diverse abiotic stress in several plant species.
Cui, Peng, Xiong, Liming
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BCAS2 Regulates Delta-Notch Signaling Activity through Delta Pre-mRNA Splicing in Drosophila Wing Development. [PDF]
PLoS ONE, 2015 Previously, we showed that BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing. In this study, we provide strong evidence that BCAS2 regulates the activity of Delta-Notch signaling via Delta pre-mRNA splicing.
Meng-Hsuan Chou +8 more
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