Results 201 to 210 of about 270,676 (398)
An Exonic Splicing Enhancer within a Bidirectional Coding Sequence Regulates Alternative Splicing of an Antisense mRNA [PDF]
, 2010 The discovery of increasing numbers of genes with overlapping sequences highlights the problem of expression in the context of constraining regulatory elements from more than one gene.
Hastings, Michelle Laura +4 more
core +1 more source
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source
The problem of selection bias in studies of pre-mRNA splicing. [PDF]
Nat Commun, 2023 Dwyer ZW, Pleiss JA.
europepmc +1 more source
Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors. [PDF]
, 1991 S Huang, David L. Spector
openalex +1 more source
Advanced Science, EarlyView.HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie +21 more
wiley +1 more source
Microsatellite Instability and Aberrant Pre-mRNA Splicing: How Intimate Is It? [PDF]
Genes (Basel), 2023 Corcos L +6 more
europepmc +1 more source
Human tenascin: primary structure, pre-mRNA splicing patterns and localization of the epitopes recognized by two monoclonal antibodies [PDF]
, 1991 Annalisa Siri +6 more
openalex +1 more source
Advanced Science, EarlyView.The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu +13 more
wiley +1 more source
A U5 Small Nuclear Ribonucleoprotein Particle Protein Involved Only in the Second Step of Pre-mRNA Splicing in Saccharomyces cerevisiae [PDF]
, 1993 David S. Horowitz, John Abelson
openalex +1 more source
Advanced Science, EarlyView.L14‐8, a small molecule derived from the marketed drug ezetimibe, potently inhibits advanced prostate cancer independent of androgen receptor signaling. L14‐8 binds PLK1, triggering its ubiquitin‐mediated degradation. This activates TP53‐dependent transcription of SAT1, inducing ferroptosis and suppressing tumor growth in prostate cancer patient ...
Yu Zhang +8 more
wiley +1 more source