Results 271 to 280 of about 270,676 (398)

Machine Learning Analysis of Whole‐Blood Transcriptomics Data in Rheumatoid Arthritis Patients Treated with Adalimumab Identifies Predictive Biomarkers of Response

Arthritis &Rheumatology, Accepted Article.
Objectives Tumor necrosis factor inhibitors (TNFi) have significantly improved rheumatoid arthritis (RA) management, yet variability in patient response remains a substantial challenge, with approximately 40% of patients discontinuing TNFi due to non‐response or adverse effects. This study aimed to identify biomarkers predictive of adalimumab treatment
Chuan Fu Yap, Nisha Nair, Ann W Morgan, John D Isaacs, Anthony G Wilson, Kimme Hyrich, Guillermo Barturen, María Riva‐Torrubia, Marta Gut, Ivo Gut, Marta E. Alarcón Riquelme, Anne Barton, Darren Plant   +12 more
wiley   +1 more source

Assessing the Impact of Novel BRCA1 Exon 11 Variants on Pre-mRNA Splicing. [PDF]

Cells
Elshwekh H, Alhudiri IM, Elzagheid A, Enattah N, Abbassi Y, Abou Assali L, Marino I, Stuani C, Buratti E, Romano M.   +9 more
europepmc   +1 more source

The ubiquitin-like protein Hub1/UBL-5 functions in pre-mRNA splicing in Caenorhabditis elegans. [PDF]

FEBS Lett, 2023
Kolathur KK, Sharma P, Kadam NY, Shahi N, Nishitha A, Babu K, Mishra SK.   +6 more
europepmc   +1 more source

Dynamic protein interactions probed by NMR spectroscopy

Bulletin of the Korean Chemical Society, EarlyView.
Abstract Dynamic protein–protein interactions are essential for diverse cellular processes but often evade structural characterization due to their transient, heterogeneous, and disordered nature. This review focuses on how nuclear magnetic resonance (NMR) spectroscopy can provide detailed, residue‐level insights into these complex interactions.
Jaeseok Lee, Jung Ho Lee
wiley   +1 more source

KHSRP ameliorates acute liver failure by regulating pre-mRNA splicing through its interaction with SF3B1. [PDF]

Cell Death Dis
Li M, Fang Q, Xiao P, Yin Z, Mei G, Wang C, Xiang Y, Zhao X, Qu L, Xu T, Zhang J, Liu K, Li X, Dong H, Xiao R, Zhou R.   +15 more
europepmc   +1 more source

Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing. [PDF]

Front Immunol, 2022
Putscher E, Hecker M, Fitzner B, Boxberger N, Schwartz M, Koczan D, Lorenz P, Zettl UK.   +7 more
europepmc   +1 more source

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

, 1990
Hui Ge, James L. Manley
openalex   +1 more source

Multiple Splicing Signals Control Alternative Intron Retention of Bovine Growth Hormone Pre-mRNA [PDF]

, 1995
Wessel P. Dirksen, Qiang Sun, Fritz Rottman   +2 more
openalex   +1 more source

5‐Aza combined with VPA reprograms human T lineage acute leukemia Jurkat cells into B‐cell‐like cells by epigenetic activation of PAX5

Biotechnology Progress, EarlyView.
Abstract Epigenetic regulation plays an important role in cell fate reprogramming. Here, we found that inhibitors of epigenetic modifiers, including VPA, TSA, and 5‐Aza‐2'‐deoxycytidine, can induce phenotypic transformation from Jurkat cells into B‐cell‐like cells. When Jurkat cells were treated with 5‐Aza combined with VPA, B cell and stem cell marker
Wenjin Xi, Guoxu Zheng, Xu Chen, Baile Zuo, Wei Wang, Yufang Li, Chunmei Zhang, Jie Chu, Xiuli Mu, Weihong Wen, Tao Wang, An‐Gang Yang   +11 more
wiley   +1 more source

A simple method to visualize pre-mRNA splicing with the naked eye using a genetically encoded visual splicing reporter. [PDF]

Plant Physiol
Prasad KVSK, Cheema A, Scanlon W, Matthews A, Sharifova S, Huq E, Reddy ASN.   +6 more
europepmc   +1 more source