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The Pre-mRNA Splicing Reaction
2014In eukaryotic organisms, nascent transcripts of protein-coding genes contain intronic sequences that are not present in mature mRNAs. Pre-mRNA splicing removes introns and joins exons to form mature mRNAs. It is catalyzed by a large RNP complex called the spliceosome. Sequences within the pre-mRNA determine intron recognition and excision. This process
Somsakul Pop, Wongpalee, Shalini, Sharma
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Human pre-mRNA splicing signals
Journal of Theoretical Biology, 1991A sample of 764 pairs of human pre-mRNA exon-intron and intron-exon boundaries, extracted from the European Molecular Biology Laboratory data bank, is analyzed to provide a species-optimized characterization of donor and acceptor sites, evaluate the information content of the two signals (found to be about 8 and 9 bits respectively) and check the ...
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1997
Abstract The formation of a mature mRNA from a primary transcript generally requires excision of intervening sequences (introns) with the subsequent joining together (splicing) of exons. The general splicing reaction of metazoan intrans has been well characterized and involves a two-step process, which occurs in a large ribonuclear ...
Yung-chih wang +2 more
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Abstract The formation of a mature mRNA from a primary transcript generally requires excision of intervening sequences (introns) with the subsequent joining together (splicing) of exons. The general splicing reaction of metazoan intrans has been well characterized and involves a two-step process, which occurs in a large ribonuclear ...
Yung-chih wang +2 more
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Pre-mRNA splicing in higher plants
Trends in Plant Science, 2000Most plant mRNAs are synthesized as precursors containing one or more intervening sequences (introns) that are removed during the process of splicing. The basic mechanism of spliceosome assembly and intron excision is similar in all eukaryotes. However, the recognition of introns in plants has some unique features, which distinguishes it from the ...
Z J, Lorković +3 more
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1995
The biogenesis of mature, functional mRNA in eukaryotes often requires the precise excision of noncoding, intervening sequences (i.e., introns) which are present in the precursor mRNA (pre-mRNA) molecule and subsequent ligation of the flanking, functional sequences (i.e., exons).
C. L. Will, P. Fabrizio, R. Lührmann
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The biogenesis of mature, functional mRNA in eukaryotes often requires the precise excision of noncoding, intervening sequences (i.e., introns) which are present in the precursor mRNA (pre-mRNA) molecule and subsequent ligation of the flanking, functional sequences (i.e., exons).
C. L. Will, P. Fabrizio, R. Lührmann
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2017
The splicing of precursor messenger RNA (pre-mRNA) requires the precise cleavage and formation of multiple phosphodiester bonds in nascent pre-mRNA polymers in order to produce a protein coding message that can be properly translated by the ribosome. Despite the precision of this process, the spliceosome maintains considerable flexibility to include ...
Matthew G. Woll +2 more
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The splicing of precursor messenger RNA (pre-mRNA) requires the precise cleavage and formation of multiple phosphodiester bonds in nascent pre-mRNA polymers in order to produce a protein coding message that can be properly translated by the ribosome. Despite the precision of this process, the spliceosome maintains considerable flexibility to include ...
Matthew G. Woll +2 more
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2000
Abstract In the late 1970s it was discovered that many eukaryotic genes are interrupted by non-coding sequences (intrans). Since then, various types of intrans have been identified, the mechanisms for their removal have been intensively researched, and the possible reasons for their existence have been the subject of much debate. Introns
Andrew E Mayes +2 more
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Abstract In the late 1970s it was discovered that many eukaryotic genes are interrupted by non-coding sequences (intrans). Since then, various types of intrans have been identified, the mechanisms for their removal have been intensively researched, and the possible reasons for their existence have been the subject of much debate. Introns
Andrew E Mayes +2 more
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Intron specificity in pre-mRNA splicing
Current Genetics, 2018The occurrence of spliceosomal introns in eukaryotic genomes is highly diverse and ranges from few introns in an organism to multiple introns per gene. Introns vary with respect to their lengths, strengths of splicing signals, and position in resident genes.
Shravan Kumar, Mishra, Poonam, Thakran
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Nuclear pre‐mRNA splicing in yeast
Yeast, 1989In this review I will summarize the genetic and biochemical approaches that have been used in Saccharomyces cerevisiae to determine the pathway of nuclear pre-mRNA splicing and to identify both cis- and trans-acting elements in these ...
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Protein functions in pre-mRNA splicing
Current Opinion in Cell Biology, 1997Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functional spliceosome formation have ...
C L, Will, R, Lührmann
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