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Examining the capacity of human U1 snRNA variants to facilitate pre-mRNA splicing. [PDF]

open access: yesRNA
Wong J   +5 more
europepmc   +1 more source

Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast. [PDF]

open access: yesRNA
Chalivendra S   +15 more
europepmc   +1 more source
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Regulation of mammalian pre-mRNA splicing

Science in China Series C: Life Sciences, 2009
In eukaryotes, most protein-coding genes contain introns which are removed by precursor messenger RNA (pre-mRNA) splicing. Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct proteins.
Jingyi Hui
exaly   +3 more sources

Pre-mRNA splicing in yeast

Trends in Genetics, 1991
Splicing of introns from nuclear precursor messenger RNAs (pre-mRNAs) occurs in all eukaryotes. Two aspects of the splicing mechanism need to be understood: how intron sequences are recognized and aligned and how splicing is catalysed. Recent genetic and biochemical studies in the simple eukaryote Saccharomyces cerevisiae are revealing some of the ...
S W, Ruby, J, Abelson
openaire   +2 more sources

Alternative Pre-mRNA Splicing

2014
Alternative pre-mRNA splicing is an integral part of gene regulation in eukaryotes. Here we provide a basic overview of the various types of alternative splicing, as well as the functional role, highlighting how alternative splicing varies across phylogeny.
Stacey D, Wagner, J Andrew, Berglund
openaire   +2 more sources

The Pre-mRNA Splicing Reaction

2014
In eukaryotic organisms, nascent transcripts of protein-coding genes contain intronic sequences that are not present in mature mRNAs. Pre-mRNA splicing removes introns and joins exons to form mature mRNAs. It is catalyzed by a large RNP complex called the spliceosome. Sequences within the pre-mRNA determine intron recognition and excision. This process
Somsakul Pop, Wongpalee, Shalini, Sharma
openaire   +2 more sources

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