Low amylose content in rice <i>lowac2</i> mutant is caused by a new allele of C<sub>2</sub>H<sub>2</sub> zinc-finger protein that regulates pre-mRNA splicing of <i>Wx<sup>b</sup></i>. [PDF]
Sakaguchi R +6 more
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Examining the capacity of human U1 snRNA variants to facilitate pre-mRNA splicing. [PDF]
Wong J +5 more
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A Newly Characterized, Two BRCT Domain-Containing Isoform of PAX-Interacting Protein (PTIP) Generated via Frame Shift and Alternative Pre-mRNA Splicing. [PDF]
Huang CJ +7 more
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Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast. [PDF]
Chalivendra S +15 more
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Correction to 'N2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing'. [PDF]
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Regulation of mammalian pre-mRNA splicing
Science in China Series C: Life Sciences, 2009In eukaryotes, most protein-coding genes contain introns which are removed by precursor messenger RNA (pre-mRNA) splicing. Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct proteins.
Jingyi Hui
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Splicing of introns from nuclear precursor messenger RNAs (pre-mRNAs) occurs in all eukaryotes. Two aspects of the splicing mechanism need to be understood: how intron sequences are recognized and aligned and how splicing is catalysed. Recent genetic and biochemical studies in the simple eukaryote Saccharomyces cerevisiae are revealing some of the ...
S W, Ruby, J, Abelson
openaire +2 more sources
Alternative pre-mRNA splicing is an integral part of gene regulation in eukaryotes. Here we provide a basic overview of the various types of alternative splicing, as well as the functional role, highlighting how alternative splicing varies across phylogeny.
Stacey D, Wagner, J Andrew, Berglund
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The Pre-mRNA Splicing Reaction
2014In eukaryotic organisms, nascent transcripts of protein-coding genes contain intronic sequences that are not present in mature mRNAs. Pre-mRNA splicing removes introns and joins exons to form mature mRNAs. It is catalyzed by a large RNP complex called the spliceosome. Sequences within the pre-mRNA determine intron recognition and excision. This process
Somsakul Pop, Wongpalee, Shalini, Sharma
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