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Structural basis of pre-mRNA splicing
Science, 2015Structure and function of the spliceosome When RNA is transcribed from DNA in the eukaryotic cell nucleus, the initial transcript includes noncoding introns that must be spliced out. This splicing is done by a complex macromolecular machine, the spliceosome, which comprises five small nuclear RNAs and more than ...
Jing, Hang +3 more
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Pre-mRNA splicing aberrations and cancer
Frontiers in Bioscience, 2008Splicing requires the accurate recognition of exonic sequences from the surrounding thousands of nucleotides of intronic sequence and is achieved by the coordinate interplay of splicing regulatory elements in genes and the trans-acting RNA and protein molecules to which they bind.
Pettigrew, C.A., Brown, M.A.
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Trans splicing of nuclear pre-mRNAs
Cell, 1990Chez les Nematodes et Trypanosomes, les substrats et facteurs, qui participent a l'epissage trans, des pre-mRNA sont etudies. Les differences qui existent entre ces modeles permettent d'avoir un apercu de l'evolution de la maturation des RNAs des protozoaires aux ...
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Regulation of Alternative Pre-mRNA Splicing
2014Alternative splicing plays a prevalent role in generating functionally diversified proteomes from genomes with a more limited repertoire of protein-coding genes. Alternative splicing is frequently regulated with cell type or developmental specificity and in response to signaling pathways, and its mis-regulation can lead to disease.
Miguel B, Coelho, Christopher W J, Smith
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Regulation of mammalian pre-mRNA splicing
Science in China Series C: Life Sciences, 2009In eukaryotes, most protein-coding genes contain introns which are removed by precursor messenger RNA (pre-mRNA) splicing. Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct proteins.
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GnRH pre-mRNA splicing: role of exonic splicing enhancer
2002Publisher Summary This chapter discusses gonadotropin-releasing hormone (GnRH) pre-mRNA splicing. GnRH plays a key role in the regulation of reproduction. It is synthesized in the preoptic area (POA) of the vertebrate brain and released from nerve terminals in the median eminence into the hypothalamic-pituitary portal vessel in a pulsatile fashion ...
Jin, Han +3 more
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1994
This chapter is focused on the splicing of nuclear pre-mRNAs in higher plants. Other aspects of plant mRNA processing such as polyadenylation and mRNA stability are discussed in recent reviews.1, 2 Nothing is known about the localization of pre-mRNA processing events in the plant nucleus or mRNA transport to the cytoplasm.
Witold Filipowicz +3 more
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This chapter is focused on the splicing of nuclear pre-mRNAs in higher plants. Other aspects of plant mRNA processing such as polyadenylation and mRNA stability are discussed in recent reviews.1, 2 Nothing is known about the localization of pre-mRNA processing events in the plant nucleus or mRNA transport to the cytoplasm.
Witold Filipowicz +3 more
openaire +1 more source
Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects
Nature Reviews Genetics, 2022Malgorzata Ewa E Rogalska +2 more
exaly