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Current Opinion in Genetics & Development, 1994
Information from yeast and mammalian pre-mRNA splicing systems has advanced our understanding of the roles of protein factors in the early steps of spliceosome assembly. New results on the stereochemistry of nuclear pre-mRNA splicing and data on the transposition of Group II self-splicing introns in vivo have fuelled the long-running debate on the ...
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Information from yeast and mammalian pre-mRNA splicing systems has advanced our understanding of the roles of protein factors in the early steps of spliceosome assembly. New results on the stereochemistry of nuclear pre-mRNA splicing and data on the transposition of Group II self-splicing introns in vivo have fuelled the long-running debate on the ...
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Pre-mRNA splicing in the new millennium
Current Opinion in Cell Biology, 2001The past year has witnessed refinements in models of spliceosome assembly pathways and in the understanding of how splicing factors of the serine/arginine-rich (SR) protein family function. The role of splicing in human genetic diseases has also received a lot of attention recently as exonic splicing enhancers become better understood.
M L, Hastings, A R, Krainer
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Intron specificity in pre-mRNA splicing
Current Genetics, 2018The occurrence of spliceosomal introns in eukaryotic genomes is highly diverse and ranges from few introns in an organism to multiple introns per gene. Introns vary with respect to their lengths, strengths of splicing signals, and position in resident genes.
Shravan Kumar, Mishra, Poonam, Thakran
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Alterations of pre‐mRNA splicing in cancer
Genes, Chromosomes and Cancer, 2005AbstractRecent genomewide analyses of alternative splicing (AS) indicate that up to 70% of human genes may have alternative splice forms, suggesting that AS together with various posttranslational modifications plays a major role in the production of proteome complexity.
Zane, Kalnina +3 more
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Pre-mRNA splicing in higher plants
Trends in Plant Science, 2000Most plant mRNAs are synthesized as precursors containing one or more intervening sequences (introns) that are removed during the process of splicing. The basic mechanism of spliceosome assembly and intron excision is similar in all eukaryotes. However, the recognition of introns in plants has some unique features, which distinguishes it from the ...
Lorković ZJ +3 more
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Biochemistry and regulation of pre-mRNA splicing
Current Opinion in Cell Biology, 1996During the past year, significant advances have been made in the field of pre-mRNA splicing. It is now clear that members of the serine-arginine-rich protein family are key players in exon definition and function at multiple steps in the spliceosome cycle.
M D, Adams, D Z, Rudner, D C, Rio
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Structural basis of pre-mRNA splicing
Science, 2015Structure and function of the spliceosome When RNA is transcribed from DNA in the eukaryotic cell nucleus, the initial transcript includes noncoding introns that must be spliced out. This splicing is done by a complex macromolecular machine, the spliceosome, which comprises five small nuclear RNAs and more than ...
Jing, Hang +3 more
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Nuclear pre‐mRNA splicing in yeast
Yeast, 1989In this review I will summarize the genetic and biochemical approaches that have been used in Saccharomyces cerevisiae to determine the pathway of nuclear pre-mRNA splicing and to identify both cis- and trans-acting elements in these ...
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Pre-mRNA splicing aberrations and cancer
Frontiers in Bioscience, 2008Splicing requires the accurate recognition of exonic sequences from the surrounding thousands of nucleotides of intronic sequence and is achieved by the coordinate interplay of splicing regulatory elements in genes and the trans-acting RNA and protein molecules to which they bind.
Pettigrew, C.A., Brown, M.A.
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Protein functions in pre-mRNA splicing
Current Opinion in Cell Biology, 1997Proteins have been implicated in an expanding variety of functions during pre-mRNA splicing. Molecular cloning has identified genes encoding spliceosomal proteins that potentially act as novel RNA helicases, GTPases, or protein isomerases. Novel protein-protein and protein-RNA interactions that are required for functional spliceosome formation have ...
C L, Will, R, Lührmann
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