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Trans splicing of nuclear pre-mRNAs
Cell, 1990Chez les Nematodes et Trypanosomes, les substrats et facteurs, qui participent a l'epissage trans, des pre-mRNA sont etudies. Les differences qui existent entre ces modeles permettent d'avoir un apercu de l'evolution de la maturation des RNAs des protozoaires aux ...
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snRNAs as the catalysts of pre-mRNA splicing
Current Opinion in Chemical Biology, 2005The spliceosome, the gigantic molecular machine that performs pre-mRNA splicing in eukaryotes, contains over 200 different proteins and five RNA molecules. The central role played by the spliceosomal RNAs in splicing has led to the hypothesis that, like the ribosome, the spliceosome is an RNA-centric enzyme and a relic from the RNA world.
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Human pre-mRNA splicing signals
Journal of Theoretical Biology, 1991A sample of 764 pairs of human pre-mRNA exon-intron and intron-exon boundaries, extracted from the European Molecular Biology Laboratory data bank, is analyzed to provide a species-optimized characterization of donor and acceptor sites, evaluate the information content of the two signals (found to be about 8 and 9 bits respectively) and check the ...
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SPLICE SITE SELECTION IN PLANT PRE-mRNA SPLICING
Annual Review of Plant Physiology and Plant Molecular Biology, 1998▪ Abstract  The purpose of this review is to highlight the unique and common features of splice site selection in plants compared with the better understood yeast and vertebrate systems. A key question in plant splicing is the role of AU sequences and how and at what stage they are involved in spliceosome assembly.
J. W. S., Brown, C. G., Simpson
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Regulation of Alternative Pre-mRNA Splicing
2014Alternative splicing plays a prevalent role in generating functionally diversified proteomes from genomes with a more limited repertoire of protein-coding genes. Alternative splicing is frequently regulated with cell type or developmental specificity and in response to signaling pathways, and its mis-regulation can lead to disease.
Miguel B, Coelho, Christopher W J, Smith
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Mechanisms of fidelity in pre-mRNA splicing
Current Opinion in Cell Biology, 2000The pre-mRNA splicing machinery consists of five small nuclear RNAs (U1, U2, U4, U5 and U6) and more than fifty proteins. Over the past year, important advances have been made in understanding how these factors function to achieve fidelity in splicing.
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1994
This chapter is focused on the splicing of nuclear pre-mRNAs in higher plants. Other aspects of plant mRNA processing such as polyadenylation and mRNA stability are discussed in recent reviews.1, 2 Nothing is known about the localization of pre-mRNA processing events in the plant nucleus or mRNA transport to the cytoplasm.
Witold Filipowicz +3 more
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This chapter is focused on the splicing of nuclear pre-mRNAs in higher plants. Other aspects of plant mRNA processing such as polyadenylation and mRNA stability are discussed in recent reviews.1, 2 Nothing is known about the localization of pre-mRNA processing events in the plant nucleus or mRNA transport to the cytoplasm.
Witold Filipowicz +3 more
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Splicing to Keep Cycling: The Importance of Pre-mRNA Splicing during the Cell Cycle
Trends in Genetics, 2021Mercedes Bentata +2 more
exaly