ChemBioChem, EarlyView.This review explores pathological disulfide‐crosslinking as a key driver of amyloidogenic protein misfolding and aggregation. Oxidative and ER stress pathways contributing to disease progression are discussed and emerging therapeutic strategies targeting disulfide‐linked aggregates in neurodegenerative and systemic amyloid diseases are examined ...
Dong Min Kang +4 more
wiley +1 more source
Importance of pre-mRNA splicing and its study tools in plants. [PDF]
Adv Biotechnol (Singap)Liu Y +6 more
europepmc +1 more source
Splicing of Two Internal and Four Carboxyl-terminal Alternative Exons in Nonmuscle Tropomyosin 5 Pre-mRNA Is Independently Regulated during Development [PDF]
, 1998 Cécile Dufour +4 more
openalex +1 more source
Computational De Novo Design of Group II Introns Yields Highly Active Ribozymes
ChemBioChem, EarlyView.Group II Introns (G2Is) are large self‐splicing ribozymes with promising biotechnological applications. This study utilized RNA inverse folding to design three novel G2Is. The designed intron Arq.I2, an unexpectedly proficient ribozyme, self‐splices not only in vitro, but also in Escherichia coli cells.
Deni Szokoli +3 more
wiley +1 more source
PRP18, a protein required for the second reaction in pre-mRNA splicing.
, 1990 Usha Vijayraghavan, John Abelson
openalex +1 more source
Six novel genes necessary for pre-mRNA splicing in Saccharomyces cerevisiae [PDF]
, 1996 Jane Maddock
openalex +1 more source
MRG15 is required for pre-mRNA splicing and spermatogenesis
Proceedings of the National Academy of Sciences of the United States of America, 2016 N. Iwamori +8 more
semanticscholar +1 more source
ChemBioChem, Accepted Article.RNAs play crucial roles in various cellular actions, and the uncontrolled expression or improper folding of RNAs is a cause of many diseases. Certain oncogenic phenotypes stem from the overexpression of regulatory microRNAs that contain secondary structural elements.
Soma Roy, Yang Liu, Peng Wu
wiley +1 more source
Short artificial hairpins sequester splicing signals and inhibit yeast pre-mRNA splicing.
, 1993 Valérie Goguel +2 more
openalex +1 more source
Alternative pre-mRNA splicing of the sterol 27-hydroxylase gene (CYP 27) caused by a G to A mutation at the last nucleotide of exon 6 in a patient with cerebrotendinous xanthomatosis (CTX) [PDF]
, 1998 Wengen Chen +2 more
openalex +1 more source