Results 291 to 300 of about 270,676 (398)

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Efficient excision of the upstream large intron from P4-generated pre-mRNA of the parvovirus minute virus of mice requires at least one donor and the 3' splice site of the small downstream intron [PDF]

, 1995
Qin Zhao, Anand Gersappe, David J. Pintel   +2 more
openalex   +1 more source

Escaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in Anucleate Platelets

Cell, 2005
M. Denis, N. Tolley, M. Bunting, H. Schwertz, Huimiao Jiang, S. Lindemann, C. C. Yost, F. Rubner, K. Albertine, K. Swoboda, Carolyn M. Fratto, E. Tolley, L. Kraiss, T. McIntyre, G. Zimmerman, A. Weyrich   +15 more
semanticscholar   +1 more source

Examining the capacity of human U1 snRNA variants to facilitate pre-mRNA splicing. [PDF]

RNA
Wong J, Yellamaty R, Gallante C, Lawrence E, Martelly W, Sharma S.   +5 more
europepmc   +1 more source

Organization of the Human Protein 4.1 Genomic Locus: New Insights into the Tissue-Specific Alternative Splicing of the Pre-mRNA

, 1997
Faouzi Baklouti, Shu‐Ching Huang, Tom Vulliamy, J. Delaunay, Edward J. Benz   +4 more
openalex   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

Pre-mRNA Splicing Modulation by Antisense Oligonucleotides.

Methods in molecular biology, 2018
N. Singh, Diou Luo, R. Singh
semanticscholar   +1 more source

What Does Iron Mean to an Oligodendrocyte?

Glia, EarlyView.
Iron is essential for oligodendrocyte (OL) biology and myelin production, with deficiencies leading to severe neurological impairments. Understanding iron trafficking in OLs is crucial for developing treatments for dysmyelinating conditions. ABSTRACT Iron is essential for life and plays a key role in multiple fundamental cellular functions.
Quinn W. Wade, James R. Connor
wiley   +1 more source

A novel mutation in GTPBP3 causes combined oxidative phosphorylation deficiency 23 by affecting pre-mRNA splicing. [PDF]

Heliyon
Wang Y, He J, Dong F, Shou W, Feng X, Yang Y, Li C, Wang J, Li B, Xiao S.   +9 more
europepmc   +1 more source