MicroRNA miR-1002 Enhances NMNAT-Mediated Stress Response by Modulating Alternative Splicing
iScience, 2019 Summary: Understanding endogenous regulation of stress resistance and homeostasis maintenance is critical to developing neuroprotective therapies. Nicotinamide mononucleotide adenylyltransferase (NMNAT) is a conserved essential enzyme that confers ...
Joun Park +6 more
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Signal-regulated Pre-mRNA occupancy by the general splicing factor U2AF. [PDF]
PLoS ONE, 2008 Alternative splicing of transcripts in a signal-dependent manner has emerged as an important concept to ensure appropriate expression of splice variants under different conditions.
Anne Tisserant, Harald König
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Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells [PDF]
, 1990 SF2, an activity necessary for 5' splice site cleavage and lariat formation during pre-mRNA splicing in vitro, has been purified to near homogeneity from HeLa cells. The purest fraction contains only two related polypeptides of 33 kD.
Conway, G. C. +2 more
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MicroRNA‐Biogenesis and Pre‐mRNA Splicing Crosstalk [PDF]
BioMed Research International, 2009 MicroRNAs (miRNAs) are often hosted in introns of protein‐coding genes. Given that the same transcriptional unit can potentially give rise to both miRNA and mRNA transcripts raises the intriguing question of the level of interaction between these processes.
Shomron, Noam, Levy, Carmit
openaire +3 more sources
Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing. [PDF]
PLoS ONE, 2007 Serine/arginine-rich (SR) proteins are essential splicing factors with one or two RNA-recognition motifs (RRMs) and a C-terminal arginine- and serine-rich (RS) domain. SR proteins bind to exonic splicing enhancers via their RRM(s), and from this position
Stephanie D Shaw +3 more
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Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing [PDF]
, 2004 Pre-mRNA processing is an important mechanism for globally modifying cellular protein composition during tumorigenesis. To understand this process during lung cancer, expression of two key pre-mRNA alternative splicing factors was compared in a mouse ...
Cosper, P. (P.F.) +8 more
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Splicing therapeutics in SMN2 and APOB [PDF]
, 2009 Splicing therapeutics are defined as the deliberate modification of RNA splicing to achieve therapeutic goals. Various techniques for splicing therapeutics have been described, and most of these involve the use of antisense oligonucleotide-based ...
Khoo, B., Krainer, A. R.
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Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae. [PDF]
, 1994 To study the functions of heterogeneous nuclear ribonucleoproteins (hnRNPs), we have characterized nuclear polyadenylated RNA-binding (Nab) proteins from Saccharomyces cerevisiae.
Datar, KV +4 more
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Truncated human endothelin receptor A produced by alternative splicing and its expression in melanoma [PDF]
, 1998 In this study, reverse transcriptase polymerase chain reaction was used to amplify human endothelin receptor A (ETA) and ETB receptor mRNA. A truncated ETA receptor transcript with exons 3 and 4 skipped was found.
Berry, PA +5 more
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Quantitative single-cell splicing analysis reveals an ‘economy of scale’ filter for gene expression [PDF]
, 2018 In eukaryotic cells, splicing affects the fate of each pre-mRNA transcript, helping to determine whether it is ultimately processed into an mRNA, or degraded. The efficiency of splicing plays a key role in gene expression.
Ding, Fangyuan, Elowitz, Michael B.
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