A Role for Pre-mRNA-PROCESSING PROTEIN 40C in the Control of Growth, Development, and Stress Tolerance in Arabidopsis thaliana [PDF]
, 2019 Because of their sessile nature, plants have adopted varied strategies for growing and reproducing in an ever-changing environment. Control of mRNA levels and pre-mRNA alternative splicing are key regulatory layers that contribute to adjust and ...
Careno, Daniel Alejandro +6 more
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Genome wide comparative analysis of the effects of PRMT5 and PRMT4/CARM1 arginine methyltransferases on the Arabidopsis thaliana transcriptome [PDF]
, 2015 BACKGROUND: Methylation at arginine residues (R) is an important post-translational modification that regulates a myriad of essential cellular processes in eukaryotes, such as transcriptional regulation, RNA processing, signal transduction and DNA repair.
Hernando, Carlos Esteban +3 more
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SnoRNP Biogenesis Meets Pre-mRNA Splicing [PDF]
Molecular Cell, 2006 In vertebrates, hundreds of small nucleolar RNAs (snoRNAs) are processed from pre-mRNA introns. In the September 1 issue of Molecular Cell, Hirose et al. (2006) demonstrate that a spliceosomal intron binding protein, IBP160, couples box C/D snoRNA processing with pre-mRNA splicing in the C1 splicing complex.
openaire +2 more sources
PLoS ONE, 2014 Most human pre-mRNAs contain introns that are removed by splicing. Such a complex process needs strict control and regulation in order to prevent the expression of aberrant or unprocessed transcripts.
Anne Hett, Steven West
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Inhibition of pre-mRNA splicing by a synthetic Blom7α-interacting small RNA.
PLoS ONE, 2012 Originally the novel protein Blom7α was identified as novel pre-mRNA splicing factor that interacts with SNEV(Prp19/Pso4), an essential protein involved in extension of human endothelial cell life span, DNA damage repair, the ubiquitin-proteasome system,
Marlies Löscher +9 more
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Post-transcriptional splicing can occur in a slow-moving zone around the gene
eLifeSplicing is the stepwise molecular process by which introns are removed from pre-mRNA and exons are joined together to form mature mRNA sequences. The ordering and spatial distribution of these steps remain controversial, with opposing models suggesting ...
Allison Coté +17 more
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Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes [PDF]
, 2007 The different steps of gene expression are intimately linked to coordinate and regulate this complex process. During transcription, numerous RNA-binding proteins are already loaded onto the nascent mRNA and package the mRNA into a messenger ...
Andersen, Ulrik L. +8 more
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Analysis of in situ pre-mRNA targets of human splicing factor SF1 reveals a function in alternative splicing [PDF]
, 2017 The conserved pre-mRNA splicing factor SF1 is implicated in 3′ splice site recognition by binding directly to the intron branch site. However, because SF1 is not essential for constitutive splicing, its role in pre-mRNA processing has remained mysterious.
Antih, Nicolas +4 more
core
The role of the Ou element in SL1 trans-splicing in C. elegans nematodes [PDF]
, 2011 The nematode C. elegans exhibits SL1 trans-splicing, a unique form of pre-mRNA Processing seen in a variety of lower metazoans. In C. elegans, there are two types of trans-spliced leader that are added onto the 5\u27 end of trans-spliced pre-mRNA: SL2 ...
Gallegos, Jenna
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The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]
, 2013 Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura +14 more
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