Results 31 to 40 of about 14,806,844 (291)

"Plasmodium falciparum" Drug Resistance, Molecular Genotyping and Generation of a Malaria Resistance Genogram by DNA Microarray-Based Technology [PDF]

, 2006
Prior to the 2001 malarial treatment policy change in Tanzania, studies were conducted to assess the efficacy of sulfadoxine-pyrimethamine (SP) and usefulness of molecular markers in monitoring SP resistance.
Mugittu, Kefas Nasongelya
core   +1 more source

Frequency of first and second-line drug resistance-associated mutations among resistant Mycobacterium tuberculosis clinical isolates from São Paulo, Brazil [PDF]

Memorias do Instituto Oswaldo Cruz, 2020
BACKGROUND Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis, and the number of new cases of multidrug resistant TB (MDR-TB), pre extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB ...
Tania Matsui, Juliana Maíra Watanabe Pinhata, Michelle Christiane da Silva Rabello, Angela Pires Brandão, Lucilaine Ferrazoli, Sylvia Cardoso Leão, Cristina Viana-Niero, Rosangela Siqueira de Oliveira   +7 more
doaj   +1 more source

HIV-1 subtypes and pre-treatment drug resistance in newly reported HIV-1-infected cases in Hongkou District， Shanghai in 2016

Shanghai yufang yixue, 2022
ObjectiveTo determine the HIV-1 subtypes and pre-treatment drug resistance （PDR） mutations in newly reported HIV-1-infected cases in Hongkou District of Shanghai， and provide evidence for the adjustment of antiretroviral therapy （ART）.MethodsA total of ...
HONG Liang, TAO Jing, LI Jiajie, JIA Min
doaj   +1 more source

Pre-treatment evaluation: Setting a foundation in the management of drug-resistant tuberculosis

El Mednifico Journal, 2014
The global emergence of resistance to the anti-tuberculosis (TB) drugs has posed a serious challenge to the efforts of program managers and the health workers all across the world to reduce the magnitude of TB. From a public health perspective, early diagnosis of drug-resistant TB cases and initiation of the patient on second-line anti-TB drugs is the ...
Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava, Jegadeesh Ramasamy   +2 more
openaire   +1 more source

Potential challenges to sustained viral load suppression in the HIV treatment programme in South Africa: a narrative overview

AIDS Research and Therapy, 2021
Background South Africa, with one of the highest HIV prevalences in the world, introduced the universal test and treat (UTT) programme in September 2016.
Pascal O. Bessong, Nontokozo D. Matume, Denis M. Tebit   +2 more
doaj   +1 more source

Utility of pre-treatment evaluation in Initiation of multi-drug resistant tuberculosis treatment

Muller Journal of Medical Sciences and Research, 2014
The emergence of resistance to the first line anti-tuberculosis) drugs has posed a significant threat to the global mission of reducing the magnitude of TB. Considering the life threatening nature of the multi-drug resistant TB (MDR-TB), in addition to the poor cure rate or success rate, high default rate or incidence of complications and the potential
Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava, Jegadeesh Ramasamy   +2 more
openaire   +2 more sources

Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing. [PDF]

, 2013
BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize
Grace P McCormack, Crampin, Amelia C., Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, Ram K Shrestha, Travers, Simon A, Simon A Travers, French, Neil, Glynn, Judith R, Crampin, Amelia C, Vijay Bansode, Judith R Glynn, Vijay Bansode, Amelia C Crampin, McCormack, Grace P, Travers, Simon A., Shrestha, Ram K., Ngwira, Bagrey, Shrestha, Ram K, Bagrey Ngwira, Bansode Vijay, French Neil, Ngwira Bagrey, Crampin Amelia C, McCormack Grace P, Travers Simon A, Glynn Judith R, Shrestha Ram K   +29 more
core   +2 more sources

Genetic Diversity and Characteristics of Drug Resistance Among Treatment-Naive People Living with HIV in Xi’an, China

Drug Design, Development and Therapy, 2023
Huan Xia,1,2,* Juan Jin,3,* Huanhuan Ba,3 Yuan Zhang,3 Jiajia Li,3 Rui Guo,3 Ying Li,3 Ping Ma,1,2 Yan Zhang3 1Department of Infectious Diseases, Tianjin Second People’s Hospital, Tianjin, 300192, People’s Republic of China; 2Tianjin Association ...
Xia H, Jin J, Ba H, Zhang Y, Li J, Guo R, Li Y, Ma P, Zhang Y   +8 more
doaj  

Identification of collateral sensitivity and evolutionary landscape of chemotherapy-induced drug resistance using cellular barcoding technology

Frontiers in Pharmacology, 2023
Background: One of the most significant challenges impeding cancer treatment effectiveness is drug resistance. Combining evolutionary understanding with drug resistance can pave the way for the identification of second-line drug options that can overcome
Nurseda Danisik, Kubra Celikbas Yilmaz, Ahmet Acar   +2 more
doaj   +1 more source

Understanding cisplatin resistance using cellular models [PDF]

, 2007
Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, M, Davey, Mary W., Davey, Mary W, Stordal, B, Britta Stordal, Mary Davey, Stordal, Britta, Stordal, B., Davey, M.   +8 more
core   +2 more sources