Results 21 to 30 of about 14,806,844 (291)

HIV-1 residual risk and pre-treatment drug resistance among blood donors: A sentinel surveillance from Gabon. [PDF]

PLoS One
Background Surveillance of HIV-1 pre-treatment drug resistance (PDR) is essential for ensuring the success of first-line antiretroviral therapy (ART). Beside population-based surveys, sentinel surveillance of PDR and circulating HIV-1 clades in specific populations such as blood donors could efficiently inform decision-making on ART program.
Mangala C, Takou D, Maulot-Bangola D, Beloumou G, Rebienot Pellegrin O, Sosso SM, Ambe Chenwi C, Ngoufack Jagni Semengue E, Vigan Codjo F, Boussougou O, Nka AD, Tommo M, Fainguem N, Kamgaing R, Ama Moor V, Kamga Gonsu H, Penlap V, Nkoa T, Colizzi V, Perno CF, Fokam J, Ndjolo A.   +21 more
europepmc   +5 more sources

Enzalutamide-induced signatures revealed by epigenetic plasticity using single-cell multi-omics sequencing in prostate cancer

Molecular Therapy: Nucleic Acids, 2023
Prostate cancer is morphologically and molecularly heterogeneous, which poses obstacles for early diagnosis and treatment. Advancements in understanding the heterogeneity of prostate cancer will help navigate through these challenges and ultimately ...
Huihui Fan, Jinze Li, Astrid M. Manuel, Zhongming Zhao   +3 more
doaj   +1 more source

Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine. [PDF]

, 2010
BACKGROUND\ud \ud It is argued that, the efficacy of anti-malarials could be prolonged through policy-mediated reductions in drug pressure, but gathering evidence of the relationship between policy, treatment practice, drug pressure and the evolution of ...
Abdulla, Salim, Bloland, Peter, Malisa, Allen L, Roper, Cally, Allen L Malisa, Salim Abdulla, Cally Roper, Patrick S Kachur, Peter Bloland, Hassan Mshinda, Kachur, Patrick S, Richard J Pearce, Pearce, Richard J, Mshinda, Hassan   +13 more
core   +1 more source

Pattern of Drug Resistance in Primary Spinal Tuberculosis: A Single-Center Study From India

Global Spine Journal, 2021
Study Design: Retrospective observational analysis. Objectives: Spinal tuberculosis accounts for about 50% of cases among extra pulmonary osteoarticular tuberculosis.
Sunil Bhosale MS (Ortho), Akil Prabhakar MS (Ortho), Sudhir Srivastava MS (Ortho), Aditya Raj MS (Ortho), Shaligram Purohit MS (Ortho), Nandan Marathe MS (Ortho)   +5 more
doaj   +1 more source

Modelling the impact of intermittent preventive treatment for malaria on selection pressure for drug resistance. [PDF]

, 2007
BACKGROUND\ud \ud Intermittent preventive treatment (IPT) is a promising intervention for malaria control, although there are concerns about its impact on drug resistance.\ud \ud METHODS\ud \ud The key model inputs are age-specific values for a) baseline
Sutherland Colin, Schellenberg, David, Roper, C., Schellenberg, D., Roper Cally, Roper, Cally, Sutherland, C., Cissé, Badara, Alexander, N., Alexander Neal, Sutherland, Colin, Schellenberg David, Cissé Badara, Alexander, Neal   +13 more
core   +1 more source

Investigation of evolutionary dynamics for drug resistance in 3D spheroid model system using cellular barcoding technology.

PLoS ONE, 2023
Complex evolutionary dynamics governing the drug resistance is one of the major challenges in cancer treatment. Understanding these mechanisms requires a sequencing technology with higher resolution to delineate whether pre-existing or de novo drug ...
Gizem Damla Yalcin, Kubra Celikbas Yilmaz, Tugce Dilber, Ahmet Acar   +3 more
doaj   +1 more source

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies. [PDF]

, 2008
BACKGROUND: Most malaria-endemic countries are implementing a change in anti-malarial drug policy to artemisinin-based combination therapy (ACT). The impact of different drug choices and implementation strategies is uncertain.
Hastings, Ian M, Day, Nicholas PJ, White, Nicholas J., Dondorp, AM, Hastings, Ian M., Dondorp, Arjen M, Dondorp, Adrianus, Hastings, Ian, Day, Nicholas P. J., Pongtavornpinyo, W, Hastings, IM, Pongtavornpinyo, Wirichada, White, Nicholas J, Day, Nicholas, Day, Nicholas P.J., Yeung, Shunmay, Day, NP, White, NJ, White, Nicholas, Dondorp, Arjen M., Yeung, S, Hastings Ian M, Dondorp Arjen M, Pongtavornpinyo Wirichada, Day Nicholas PJ, Yeung Shunmay, White Nicholas J   +26 more
core   +1 more source

Drug resistance with monitored adherence [PDF]

, 2013
Drug resistance can be defined as the failure of a drug to exert its expected effect on pharmacological biomarkers and is caused by pharmacogenetic, cellular or clinical factors.
Walter, Philipp Niklaus
core   +1 more source

Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania. [PDF]

, 2006
BACKGROUND\ud \ud Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of uncomplicated Plasmodium falciparum malaria in many African countries.
Mbugi, Erasto V, Balthazary Sakurani T, Malisa, Allen L, Mbugi Erasto V, Allen L Malisa, Nyambo, Thomas B, Nyambo, T.B., Mutayoba, B.M., Mutayoba Benezeth M, Nyambo Thomas B, Balthazary, Sakurani T, Erasto V Mbugi, Balthazary, S.T., Hassan Mshinda, Mshinda, H., Mshinda Hassan, Benezeth M Mutayoba, Sakurani T Balthazary, Malisa Allen L, Mutayoba, Benezeth M, Mbugi, E.V., Thomas B Nyambo, Mshinda, Hassan, Malisa, A.L.   +23 more
core   +1 more source

HIV Drug Resistance among Pre-treatment Cases in Thailand: Four Rounds of Surveys during 2006-2013

Outbreak, Surveillance, Investigation & Response (OSIR) Journal, 2023
In Thailand, antiretroviral therapy (ART) was initiated to treat human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) cases using the empirical regimen with no prior genotypic test to determine drug resistance. In order to assess prevalence rate of HIV drug resistance (HIVDR) among pre-treatment cases, four rounds ...
Sombat, Thanprasertsuk, Kunjanakorn, Phokhasawad, Achara, Teeraratkul, Sanchai, Chasombat, Naparat, Pattarapayoon, Siriphan, Saeng-Aroon, Porntip, Yuktanon, Surapol, Kohreanudom, Cheewanan, Lertpiriyasuwat   +8 more
openaire   +2 more sources