Results 1 to 10 of about 447,077 (116)

Pre-Treatment HIV Drug Resistance and Genetic Diversity in Cameroon: Implications for First-Line Regimens

Viruses, 2023
The efficacy of first-line antiretroviral therapy (ART) may be hampered by the presence of HIV drug resistance (HIVDR). We described HIV-1 pre-treatment drug resistance (PDR) patterns, effect of viral clades on PDR, and programmatic implications on first-
Joseph Fokam, Collins Ambe Chenwi, Valère Tala, Désiré Takou, Maria Mercedes Santoro, George Teto, Beatrice Dambaya, Felix Anubodem, Ezechiel Ngoufack Jagni Semengue, Grace Beloumou, Sandrine Djupsa, Edgar Assomo, Charles Fokunang, Claudia Alteri, Serge Billong, Nounouce Pamen Bouba, Rogers Ajeh, Vittorio Colizzi, Dora Mbanya, Francesca Ceccherini-Silberstein, Carlo-Federico Perno, Alexis Ndjolo   +21 more
doaj   +3 more sources

High levels of pre‐treatment HIV drug resistance and treatment failure in Nigerian children

Journal of the International AIDS Society, 2016
Introduction Pre‐treatment HIV drug resistance (PDR) is an increasing problem in sub‐Saharan Africa. Children are an especially vulnerable population to develop PDR given that paediatric second‐line treatment options are limited.
Ragna S Boerma, T Sonia Boender, Kim C.E. Sigaloff, Tobias F Rinke de Wit, Michael Boele vanHensbroek, Nicaise Ndembi, Titilope Adeyemo, Edamisan O Temiye, Akin Osibogun, Pascale Ondoa, Job C Calis, Alani Sulaimon Akanmu   +11 more
doaj   +2 more sources

Prevalence and Correlates of Pre-Treatment HIV Drug Resistance among HIV-Infected Children in Ethiopia

Viruses, 2019
Pediatric human immunodeficiency virus (HIV) care in resource-limited settings remains a major challenge to achieving global HIV treatment and virologic suppression targets, in part because the administration of combination antiretroviral therapies (cART)
Birkneh Tilahun Tadesse, Olivia Tsai, Adugna Chala, Tolossa Eticha Chaka, Temesgen Eromo, Hope R. Lapointe, Bemuluyigza Baraki, Aniqa Shahid, Sintayehu Tadesse, Eyasu Makonnen, Zabrina L. Brumme, Eleni Aklillu, Chanson J. Brumme   +12 more
doaj   +3 more sources

Full-Spectrum Surveillance of Pre-Treatment HIV Drug Resistance in Southeastern China

Pharmaceuticals
HIV drug resistance compromises the ability of anti-retroviral therapy (ART) to suppress viral replication, resulting in treatment failure. This study investigates the prevalence of pre-treatment drug resistance (PDR) in newly diagnosed individuals in a ...
Jiafeng Zhang, Baochang Sun, Zihang Sheng, Xiaobei Ding, Qin Fan, Gang Huang, Zhihong Guo, Ping Zhong, Lingjie Liao, Hui Xing, Yan Xia, Chengliang Chai, Jianmin Jiang   +12 more
doaj   +3 more sources

The New Definition and Epidemiology of Extensive Drug Resistant Tuberculosis in 2020

Туберкулез и болезни лёгких, 2023
The objective: to study the epidemiology and incidence of XDR tuberculosis given the updated definition.Subjects and Methods. The results of replies to the specialized inquiry by the Russian Ministry of Health about results of microbiological diagnostics
S. A. Sterlikov, I. A. Vasilyeva, Yu. V. Mikhaylova, V. G. Kudrina, V. V. Testov   +4 more
doaj   +1 more source

High prevalence of pre-treatment HIV drug resistance in Papua New Guinea: findings from the first nationally representative pre-treatment HIV drug resistance study

BMC Infectious Diseases, 2022
Background Determining the prevalence of pre-treatment HIV drug resistance (PDR) is important to assess the effectiveness of first-line therapies. To determine PDR prevalence in Papua New Guinea (PNG), we conducted a nationally representative survey ...
Janet Gare, Ben Toto, Percy Pokeya, Linh-Vi Le, Nick Dala, Namarola Lote, Bangan John, Abel Yamba, Kevin Soli, Joshua DeVos, Heather Paulin, Nick Wagar, Du-Ping Zheng, Takeshi Nishijima, Peniel Boas, Angela Kelly-Hanku, Anup Gurung   +16 more
doaj   +1 more source

Guidelines are needed for studies of pre-treatment HIV drug resistance: a methodological study

BMC Medical Research Methodology, 2021
Background The expansion of access to antiretroviral therapy (ART) has been accompanied by an increase in pre-treatment drug resistance (PDR). While it is critical to monitor the increasing prevalence of PDR across countries and populations to inform ...
Lawrence Mbuagbaw, Clémence Ongolo-Zogo, Olivia C. Mendoza, Babalwa Zani, Frederick Morfaw, Agatha Nyambi, Annie Wang, Michel Kiflen, Hussein El-Kechen, Alvin Leenus, Mark Youssef, Nadia Rehman, Lucas Hermans, Virginia MacDonald, Silvia Bertagnolio   +14 more
doaj   +1 more source

Whole-Genome Sequencing for Resistance Prediction and Transmission Analysis of Mycobacterium tuberculosis Complex Strains from Namibia

Microbiology Spectrum, 2022
Namibia is among 30 countries with a high burden of tuberculosis (TB), with an estimated incidence of 460 per 100,000 population and around 800 new multidrug-resistant (MDR) TB cases per year.
M. Claassens, V. Dreyer, E. Nepolo, Q. Mokomele, G. van Rooyen, N. Ruswa, G. Günther, S. Niemann   +7 more
doaj   +1 more source

Two cases of pre-extensively drug resistant tuberculosis in children in Indonesia

Respiratory Medicine Case Reports, 2021
Few reports are available on children with pre-extensively drug-resistant tuberculosis (pre-XDR-TB), which is defined as Mycobacterium tuberculosis resistant to both isoniazid and rifampicin plus resistance to either a fluoroquinolone or a second-line ...
Heda Melinda Nataprawira, Indah Septiane, Sri Sudarwati, Diah Asri Wulandari   +3 more
doaj   +1 more source

Drug hypersensitivity in drug-resistant tuberculosis

World Allergy Organization Journal, 2023
Objective: To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods: This was a retrospective study.
Zeynep Yegin Katran, MD, İsmet Bulut, MD, Aylin Babalık, MD, Metin Keren, MD, Fatma Merve Tepetam, MD, Selver Seda Mersin, MD, Cihan Örçen, MD, Tuğçe Yakut, MD, Dilek Yavuz, MD   +8 more
doaj   +1 more source