Results 71 to 80 of about 9,400 (263)
Production and Manufacturing Research: An Open Access Journal, 2018 Process planning and scheduling decisions are independently performed in a manufacturing system in traditional approaches. Integration of these two decisions provides significant benefits such as enhancing the productivity of manufacturing resources ...
Elahe Shokouhi
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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A GENETIC ALGORITHM FOR THE RESOURCE CONSTRAINED PROJECT SCHEDULING PROBLEM (RCPSP)
Investigación & Desarrollo, 2008 This paper proposes a Genetic Algorithm (GA) for the Resource Constrained Project Scheduling Problem (RCPSP). Resources are renewable and there is a unique way to perform the activities.
Edgar Gutiérrez Franco +2 more
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Ordering with precedence constraints and budget minimization
CoRR, 2015 We introduce a variation of the scheduling with precedence constraints problem that has applications to molecular folding and production management. We are given a bipartite graph $H=(B,S)$. Vertices in $B$ are thought of as goods or services that must be \emph{bought} to produce items in $S$ that are to be \emph{sold}. An edge from $j\in S$ to $i\in B$
Jeff Kinne +3 more
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Optimal task sequencing with precedence constraints
Discrete Mathematics, 1973 AbstractA given finite set of tasks, having known nonnegligible failure probabilities and known costs (or rewards) for their performance, can be performed sequentially until either one of the tasks fails or all tasks have been executed. The allowable task performance sequences are constrained only by certain precedence requirements, which specify that ...
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
IEEE Access, 2017 In order to disclose possible links and implications pertaining to aircraft performance, flight safety, and human factors in the aviation system, an optimal controller, a robust controller, and an adaptive decision maker were devised and organized within
Tangwen Yin, Dan Huang, Shan Fu
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