Results 91 to 100 of about 34,352 (289)

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Precedentes judiciais no novo CPC [PDF]

, 2016
[por] O novo CPC apresenta clara opção legislativa de primazia aos precedentes judiciais na solução dos conflitos. A migração do "civil Law" para o "common Law" gera maior responsabilidade na edição dos precedentes judiciais que devem gozar de ...
Costa, Hedvaldo Caldeira, Silva, Marina Braga da   +1 more
core  

Precedentes Algorítmicos

DAT Journal
Esta pesquisa investiga a lógica computacional por trás de formas arquitetônicas geradas parametricamente, visando criar novos modelos com base em princípios lógicos análogos aos casos analisados. Parte-se da premissa de que há uma relação intrínseca entre a forma arquitetônica e as regras matemáticas que as produziram, permitindo a hipótese inversa ...
openaire   +1 more source

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Necesidad de precedentes arbitrales en laudos en derecho en relación a la tutela judicial efectiva

El presente trabajo de titulación tiene como fin analizar la necesidad de precedentes arbitrales en laudos en derecho en relación a la tutela judicial efectiva, busca garantizar una protección más amplia y completa de derechos y garantías al momento de ...
Jiménez Naranjo, Adrián Ismael
core   +1 more source

Tribunal Constitucional de Bolivia: precedentes constitucionales: precedentes constitucionales afirman: la doctrina del Tribunal Constitucional

, 2009
Tribunal Constitucional de Bolivia: precedentes constitucionales: precedentes constitucionales afirman: la doctrina del Tribunal ...
Farjat, Silvia Salame
core  

Os precedentes judiciais no sistema arbitral brasileiro [PDF]

, 2018
Orientador: Paulo Roberto Ribeiro NalinMonografia (Graduação) - Universidade Federal do Paraná, Setor de Ciências Jurídicas, Curso de Graduação em DireitoResumo: O presente trabalho trata da aplicação dos precedentes judiciais no sistema arbitral.
Menin, Leonardo Catto, 1994-
core  

Doutrina de precedentes e organização judiciária [PDF]

, 2007
Discorre sobre a importância de uma doutrina de precedentes apta a produzir jurisprudência e da organização judiciária dos tribunais. Trata do acesso à justiça. Ressalta que a especialização nos tribunais é mais importante que a especialização de varas
Beneti, Sidnei Agostinho, Sidnei Agostinho Beneti   +1 more
core   +1 more source