Results 71 to 80 of about 5,703 (246)

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

Precedentes Algorítmicos

DAT Journal
Esta pesquisa investiga a lógica computacional por trás de formas arquitetônicas geradas parametricamente, visando criar novos modelos com base em princípios lógicos análogos aos casos analisados. Parte-se da premissa de que há uma relação intrínseca entre a forma arquitetônica e as regras matemáticas que as produziram, permitindo a hipótese inversa ...
openaire   +1 more source

Temperature Correction in a Single Luminophore Pressure‐Sensitive Paint Using a Dual‐Emitting Gold Acridine Complex

Advanced Optical Materials, EarlyView.
The use of pressure‐sensitive luminescent molecules to quantify surface pressure in wind tunnel testing has revolutionized experimental aerodynamics. This work develops a dual‐emitting gold acridine complex for the simultaneous sensing of pressure and temperature independently of each other.
Alexander C. Brannan, Nguyen Le Phuoc, Mikko Linnolahti, Mark K. Quinn, Alexander S. Romanov, Elliott J. Nunn   +5 more
wiley   +1 more source

A UNIDADE DO SISTEMA DECISÓRIO: O ENTENDIMENTO DO STJ NA RECLAMAÇÃO 36.476/SP NO UNIVERSO DOS PRECEDENTES VINCULANTES

Revista de Estudos Jurídicos da UNESP
Este artigo analisará o julgamento da Reclamação 36.476/SP, decidida pelo Superior Tribunal de Justiça (STJ) em 2020, em que o Tribunal adotou o entendimento de que não é cabível a reclamação para garantir a adequada aplicação de precedentes fixados ...
Lucas Oliveira Faria, Marcelo Rodrigues Mazzei, Sebastião Sérgio da Silveira   +2 more
doaj  

El Concilio Vaticano II (1962-1965) y la normativa sobre arte sagrado. Precedentes e influencia

Estudios Eclesiásticos, 2017
Los estudios sobre la normativa del arte cristiano contemporáneo han centrado su atención de manera mayoritaria en el magisterio del Concilio Vaticano II.
Víctor Marín Navarro
doaj  

Multimodal Human–Robot Interaction Using Human Pose Estimation and Local Large Language Models

Advanced Robotics Research, EarlyView.
A multimodal human–robot interaction framework integrates human pose estimation (HPE) and a large language model (LLM) for gesture‐ and voice‐based robot control. Speech‐to‐text (STT) enables voice command interpretation, while a safety‐aware arbitration mechanism prioritizes gesture input for rapid intervention.
Nasiru Aboki, Ilche Georgievski, Marco Aiello   +2 more
wiley   +1 more source

Intravital Multimodal Imaging of Human Cortical Organoid Transplantation in a Mouse Model of Chronic Stroke

Advanced Science, EarlyView.
A multimodal intravital imaging platform enables longitudinal tracking of human cortical organoids transplanted into chronic stroke lesions. By combining surgical microscopy, MRI, bioluminescence imaging, and two‐photon fluorescence microscopy, the platform captures graft placement, viability dynamics, and cellular‐scale morphology in vivo, offering a ...
Jinghui Wang, Guanda Qiao, Honglin Tan, Colleen Russel, Baixuan Yang, Mengyang Jacky Li, Kexin Wang, Jiadi Xu, Chengyan Chu, Miroslaw Janowski, Tian‐Ming Fu, Piotr Walczak, Yajie Liang   +12 more
wiley   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

“Quando [é] necessário” o acesso pela defesa aos elementos de prova? O ART. 3-b, XV, CPP à luz dos precedentes da SV14

Boletim IBCCRIM
O objetivo deste texto é analisar os acórdãos que fundamentaram a edição da súmula vinculante 14, para melhor compreender as alterações legislativas ocorridas a partir de 2009 quanto ao caráter sigiloso da investigação e direito de acesso do investigado ...
Henrique de Sá Valadão Lopes
doaj  

Integrating Machine Learning With Constant‐Potential Simulation to Unravel Charge‐Transfer Mechanisms in Electrochemical Nitrogen Fixation

Advanced Science, EarlyView.
Integrating interpretable machine learning with the fixed‐potential method reveals a novel mechanism: the catalytic activity of the electrochemical nitrogen reduction reaction is governed by partial charge transfer, induced by variations in the intermediate potential of zero charge under constant potential.
Yufei Xue, Dushuo Feng, Yuefei Zhang, Yang Zhang, Yalong Jiao, Aijun Du, Guoping Gao   +6 more
wiley   +1 more source