Results 51 to 60 of about 1,239,816 (243)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Precision N-glycoproteomics reveals the essential role of the extracellular matrix in tropomyosin allergy in a mouse model

Food Science and Human Wellness
Approximately 2.5% of the global population experience allergic reactions to seafood, making it one of the most prevalent and life-threatening allergies.
Guirong Liu, Qianwei Wang, Yibo Luo, Lijuan Sun, Ruolin Song, Huilian Che, Changqi Liu, Xiaohui Guo   +7 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The precision principle: driving biological self-organization

Frontiers in Network Physiology
In this perspective, we introduce the Precision Principle as a unifying theoretical framework to explain self-organization across biological systems.
Raymond Roy, Raymond Roy, Kiranpreet Sidhu, Kiranpreet Sidhu, Gabriel Byczynski, Amedeo D’Angiulli, Amedeo D’Angiulli, Birgitta Dresp-Langley   +7 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Precision evaluation of 2 CT-based radiostereometric analysis systems in a cadaver study

Acta Orthopaedica
Background and purpose: To address the limitations of radiostereometric imaging and to eliminate the need for intraoperative marker placement, CT-based radiostereometric analysis (CT-RSA) software systems have been developed.
Maaike R de Bondt, Frank-David Øhrn, Lars H W Engseth, Anselm Schulz, Bart L Kaptein, Stephan M Röhrl, Petra J C Heesterbeek   +6 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Artificially induced and precise small-scaled infection with Plasmopara viticola on living vines

OENO One
Grapevine downy mildew, caused by the oomycete Plasmopara viticola, affects most of the world’s finest and widely planted grapevine (Vitis vinifera L.) cultivars and is typically controlled by fungicides, which are often applied in excess.
Melissa Kleb, Reinhard Zipper, Nikolaus Merkt, Christian Zörb   +3 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Reporting and interpreting statistical results in veterinary medicine: Calling for change

Journal of Veterinary Internal Medicine
Understanding and correctly interpreting statistical results presented in scientific articles is a required skill for practicing evidence‐based veterinary medicine.
Hsin‐Yi Weng, Locksley L. McV. Messam
doaj   +1 more source