Results 41 to 50 of about 4,218,282 (383)
Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]
, 2018 The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core +1 more source
Journal of Internal Medicine, 2023 Complex diseases are caused by a combination of genetic, lifestyle, and environmental factors and comprise common noncommunicable diseases, including allergies, cardiovascular disease, and psychiatric and metabolic disorders.
Å. Johansson +9 more
semanticscholar +1 more source
Snapshot: Trial Types in Precision Medicine. [PDF]
, 2020 Integrating precision diagnostics into personalized treatments requires understanding how biomarkers relate to clinical outcomes. Various clinical data collection methods exist, each with strengths and weaknesses. Interventional data are high quality but
Bergan, Raymond +5 more
core
Arteriosclerosis, Thrombosis and Vascular Biology, 2023 Cardiovascular diseases (CVD) are the leading cause of death worldwide and display complex phenotypic heterogeneity caused by many convergent processes, including interactions between genetic variation and environmental factors.
Ruisheng Wang, B. Maron, J. Loscalzo
semanticscholar +1 more source
Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome. [PDF]
, 2017 In the 50 years since acute respiratory distress syndrome (ARDS) was first described, substantial progress has been made in identifying the risk factors for and the pathogenic contributors to the syndrome and in characterising the protein expression ...
Calfee, Carolyn S, Meyer, Nuala J
core +1 more source
Drug-microbiota interactions: an emerging priority for precision medicine
Signal Transduction and Targeted Therapy, 2023 Individual variability in drug response (IVDR) can be a major cause of adverse drug reactions (ADRs) and prolonged therapy, resulting in a substantial health and economic burden.
Qing Zhao +4 more
semanticscholar +1 more source
Developing precision stroke imaging. [PDF]
, 2014 Stroke experts stand at the cusp of a unique opportunity to advance the care of patients with cerebrovascular disorders across the globe through improved imaging approaches.
Feldmann, Edward, Liebeskind, David S
core +2 more sources
Precision Medicine in Lung Cancer
European Medical Journal Oncology, 2020 Lung cancer has a devastating global impact, with diagnosis of more than 2 million new cases annually, and poor long-term survival. Recently, the landscape of lung cancer diagnosis, staging, and treatment has changed profoundly, with further developments
Esha Joshi
doaj +1 more source
Precision medicine informatics [PDF]
Journal of the American Medical Informatics Association, 2016 This special issue on precision medicine informatics flowed from the AMIA 2015 Translational Bioinformatics Summit theme of “Accelerating Precision Medicine”1 and President Obama’s 2015 State of the Union call “to give all of us access to the personalized information we need to keep ourselves and our families healthier.”2 The goal is to focus on the ...
Frey, Lewis J +2 more
openaire +3 more sources
Precision Medicine for Obesity [PDF]
Digestive Disease Interventions, 2021 AbstractObesity is a multifactorial disease with a variable and underwhelming weight loss response to current treatment approaches. Precision medicine proposes a new paradigm to improve disease classification based on the premise of human heterogeneity, with the ultimate goal of maximizing treatment effectiveness, tolerability, and safety.
Lizeth Cifuentes +3 more
openaire +3 more sources