Results 61 to 70 of about 1,104,938 (358)

Precision Medicine: Tailoring Therapies for Individual Patient Needs [PDF]

, 2023
Precision medicine is a novel paradigm in healthcare that refers to a revolutionary method of customising medicinal therapies for specific individuals.
Gouri Tamhankar, et al.
core   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Precision Medicine in Systemic Mastocytosis

Medicina, 2021
Mastocytosis is a rare hematological neoplasm characterized by the proliferation of abnormal clonal mast cells (MCs) in different cutaneous and extracutaneous organs.
Maura Nicolosi, Andrea Patriarca, Annalisa Andorno, Abdurraouf Mokhtar Mahmoud, Alessandra Gennari, Renzo Boldorini, Gianluca Gaidano, Elena Crisà   +7 more
doaj   +1 more source

Genetics update: monogenetics, polygene disorders and the quest for modifying genes [PDF]

, 2018
The genetic channelopathies are a broad collection of diseases. Many ion channel genes demonstrate wide phenotypic pleiotropy, but nonetheless concerted efforts have been made to characterise genotype-phenotype relationships.
Symonds, Joseph D., Zuberi, Sameer M.
core   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Precision medicine in mood disorders

PCN Reports, 2022
The choice of the most appropriate psychoactive medication for each of our patients is always a challenge. We can use more than 100 psychoactive drugs in the treatment of mood disorders, which can be prescribed either alone or in combination.
Alessandro Serretti
doaj   +1 more source

Coronary Physiology: Delivering Precision Medicine?

Reviews in Cardiovascular Medicine, 2022
Coronary physiological assessment is now widely used to assess epicardial coronary lesions in cath lab. Based on clinical evidence, fractional flow reserve (FFR) is the gold standard method to select whether epicardial coronary lesions need ...
Laura Maitre-Ballesteros, Laurent Riou, Stephanie Marliere, Marjorie Canu, Estelle Vautrin, Nicola Piliero, Oliviez Ormezzano, Helene Bouvaist, Alexis Broisat, Catherine Ghezzi, Daniel Fagret, Gérald Vanzetto, Loïc Djaïleb, Gilles Barone-Rochette   +13 more
doaj   +1 more source

Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs [PDF]

, 2019
We endeavored to identify objective blood biomarkers for pain, a subjective sensation with a biological basis, using a stepwise discovery, prioritization, validation, and testing in independent cohorts design. We studied psychiatric patients, a high risk
Jones, T., Judd, S., Khan, F., Kurian, S. M., Le-Niculescu, H., Levey, D. F., McCormick, M.A., Niculescu, A. B., Rogers, J., Roseberry, K., Soe, K. C., Wessel, A. R., White, F. A., Williams, A.   +13 more
core   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Precision medicine for suicidality: from universality to subtypes and personalization [PDF]

, 2017
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders.
Ballew, A, Dainton, H L, Gelbart, T, Graham, D L, Jones, T J, Kurian, S M, Le-Niculescu, H, Levey, D F, Niculescu, A B, Niculescu, E M, Niezer, J O, Phalen, P L, Roseberry, K, Salomon, D R, Sandusky, G E, Schork, N J, Shekhar, A, Venugopal, V, Williams, A, Yard, M   +19 more
core   +1 more source