Results 1 to 10 of about 1,227,969 (402)

Human Metastatic Cholangiocarcinoma Patient-Derived Xenografts and Tumoroids for Preclinical Drug Evaluation. [PDF]

Clin Cancer Res, 2023
Abstract Purpose: Cholangiocarcinoma (CCA) is usually diagnosed at advanced stages, with limited therapeutic options. Preclinical models focused on unresectable metastatic CCA are necessary to develop rational treatments. Pathogenic mutations in IDH1/2, ARID1A/B, BAP1, and BRCA1/2 have been identified
Serra-Camprubí Q, Verdaguer H, Oliveros W, Lupión-Garcia N, Llop-Guevara A, Molina C, Vila-Casadesús M, Turpin A, Neuzillet C, Frigola J, Querol J, Yáñez-Bartolomé M, Castet F, Fabregat-Franco C, Escudero-Iriarte C, Escorihuela M, Arenas EJ, Bernadó-Morales C, Haro N, Giles FJ, Pozo ÓJ, Miquel JM, Nuciforo PG, Vivancos A, Melé M, Serra V, Arribas J, Tabernero J, Peiró S, Macarulla T, Tian TV.   +30 more
europepmc   +8 more sources

Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation. [PDF]

Trends Pharmacol Sci, 2023
Timely intervention of preventative and therapeutic measures abated a 2022 mpox global outbreak. However, the high transmissibility and unique pathological characteristics of mpox demand further investigation. Here, we discuss the potentials of human skin-on-a-chip as a valuable model for mpox disease evaluation, to achieve in-depth physiological ...
Zhu J, Abaci HE.
europepmc   +4 more sources

Advances in preclinical evaluation of experimental antibody-drug conjugates

Cancer Drug Resistance, 2021
The ability to chemically modify monoclonal antibodies with the attachment of specific functional groups has opened up an enormous range of possibilities for the targeted treatment and diagnosis of cancer in the clinic. As the number of such antibody-based drug candidates has increased, so too has the need for more stringent and robust preclinical ...
Scott K. Lyons, Dennis Plenker, Lloyd C. Trotman   +2 more
openalex   +5 more sources

An Evaluation of the Efficacy of Preclinical Models of Lung Cancer Drugs [PDF]

, 2020
AbstractBackgroundPreclinical cell models are the mainstay in the early stages of drug development. We sought to explore the preclinical data that differentiated successful from failed therapeutic agents in lung cancer.Methods134 failed lung cancer drugs and 27 successful lung cancer drugs were identified. Preclinical data were evaluated.
Elizabeth Pan, David Bogumil, Victoria K. Cortessis, Sherrie Yu, Jorge J. Nieva   +4 more
openalex   +3 more sources

Pre-Clinical Tools for Predicting Drug Efficacy in Treatment of Tuberculosis [PDF]

Microorganisms, 2022
Combination therapy has, to some extent, been successful in limiting the emergence of drug-resistant tuberculosis. Drug combinations achieve this advantage by simultaneously acting on different targets and metabolic pathways.
Hasmik Margaryan, Dimitrios D. Evangelopoulos, Leticia Muraro Wildner, Timothy D. McHugh   +3 more
doaj   +3 more sources

Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach. [PDF]

Clin Cancer Res, 2023
Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA.   +26 more
europepmc   +4 more sources

Comparative evaluation of recommendations for preclinical studies of transporter-mediated drug–drug interactions

Регуляторные исследования и экспертиза лекарственных средств, 2023
Scientific relevance. Sound recommendations for preclinical studies of transporter- mediated pharmacokinetic interactions of medicinal products can help increase the likelihood of identifying potentially nephrotoxic and hepatotoxic medicinal products at ...
V. A. Evteev, N. D. Bunyatyan, E. Yu. Demchenkova, A. B. Prokofiev   +3 more
doaj   +2 more sources

Preclinical Data on Efficacy of 10 Drug-Radiation Combinations: Evaluations, Concerns, and Recommendations

Translational Oncology, 2016
Clinical testing of new therapeutic interventions requires comprehensive, high-quality preclinical data. Concerns regarding quality of preclinical data have been raised in recent reports. This report examines the data on the interaction of 10 drugs with radiation and provides recommendations for improving the quality, reproducibility, and utility of ...
Helen B. Stone, Eric J. Bernhard, C. Norman Coleman, James A. Deye, Jacek Capala, James B. Mitchell, J. Martin Brown   +6 more
openalex   +4 more sources

Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles. [PDF]

, 2012
This study presents a new multimodal imaging approach that includes high-frequency ultrasound, fluorescence intensity, confocal, and spectral imaging to improve the preclinical evaluation of new therapeutics in vivo.
Chu, David, Farkas, Daniel L, Hwang, Jae Youn, Kang, Bong Jin, Lubow, David J, Medina-Kauwe, Lali K, Park, Jinhyoung, Shung, K Kirk   +7 more
core   +19 more sources

P2X7 Receptor Agonist 2′(3′)-O-(4-Benzoylbenzoyl)ATP Differently Modulates Cell Viability and Corticostriatal Synaptic Transmission in Experimental Models of Huntington’s Disease

Frontiers in Pharmacology, 2021
Huntington’s disease (HD) is a life-threatening neurodegenerative disorder. Altered levels and functions of the purinergic ionotropic P2X7 receptors (P2X7Rs) have been found in animal and cellular models of HD, suggesting their possible role in the ...
Alberto Martire, Rita Pepponi, Francesco Liguori, Cinzia Volonté, Cinzia Volonté, Patrizia Popoli   +5 more
doaj   +1 more source