Editorial: Recent advancements and developments in targeted drug delivery systems for cancer diagnosis and therapy. [PDF]
Mehata AK+2 more
europepmc +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth+2 more
wiley +1 more source
Strategy for reproductive and developmental toxicity (DART) studies for marketing applications in pharmaceutical development. [PDF]
Kagawa Y+4 more
europepmc +1 more source
3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram+5 more
wiley +1 more source
Glioma drug development benefits from emerging phase 0 and window-of-opportunity trial paradigm. [PDF]
Jiang S, Zhong C.
europepmc +1 more source
This comprehensive review explores therapeutic titanium implants designed to enhance integration and provide superior antibacterial efficacy. It is focused on anodized titanium implants with titania nanotubes (TNTs) loaded with nanoparticles (NPs) for local therapeutic release, enhancing bioactivity and bactericidal functions.
Divya Chopra+5 more
wiley +1 more source
Enhancing clinical translation of analgesics for neuropathic pain: a systematic review and meta-analysis on the role of non-evoked pain assessment in preclinical trials. [PDF]
Huerta MÁ+4 more
europepmc +1 more source
Lanthanide ytterbium ions are introduced into Bi2WO6 nanosheets to boost ROS generation under US stimulation. These ytterbium‐doped Bi2WO6 nanosheets serve as efficient sonosensitizers, enabling broad‐spectrum bacterial eradication. To improve biocompatibility for in vivo sonodynamic therapy, the sonosensitizers are integrated into hydrogel matrix ...
Xinyue Lao+6 more
wiley +1 more source
The Impact of Animal Models and Strain Standardization on the Evaluation of Tuberculosis Vaccine Efficacy. [PDF]
Wei J+12 more
europepmc +1 more source