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Evaluation of Nanoparticle Drug-Delivery Systems used in Preclinical Studies
Therapeutic Delivery, 2021Multifunctional nanoparticles have been identified as a promising drug-delivery system for sustainable drug release. The structural and size tunability and disease-targeting ability of nanoparticles have made them more suitable for multiple drug loading and delivery, thereby enhancing therapeutic results through synergistic effects.
Nagaraja Sreeharsha +3 more
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Preclinical evaluation of behavioral deficits following hypnotic drug treatment
Pharmacology Biochemistry and Behavior, 1986Most hypnotic medications result in performance decrements, or "hangover effects," the morning after bedtime ingestion. However, the severity of hangover effects with new compounds is difficult to predict prior to clinical trials. This paper describes a preclinical procedure that is predictive of human hangover effects following bedtime ingestion of ...
J M, Halperin, J, Canon, L C, Iorio
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Technological Advances in Preclinical Drug Evaluation: The Role of -Omics Methods
Current Medicinal Chemistry, 2020Preclinical drug development is an essential step in the drug development process where the evaluation of new chemical entities occurs. In particular, preclinical drug development phases include deep analysis of drug candidates’ interactions with biomolecules/targets, their safety, toxicity, pharmacokinetics, metabolism by use of assays in vitro and ...
Kraljević Pavelić, Sandra +4 more
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NCI Specialized Procedures in Preclinical Drug Evaluations
2004Agents now come to the U.S. National Cancer Institute (NCI) from many sources for preclinical evaluation and/or potential development (1). In most cases, experimental agents have limited antiproliferative data against a broad spectrum of human cancers, and these agents usually are then tested in the NCI’ s in vitro anticancer drug screen. Data from the
Melinda G. Hollingshead +4 more
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EGFR-targeted anti-cancer drugs in radiotherapy: Preclinical evaluation of mechanisms
Radiotherapy and Oncology, 2007Preclinical and clinical results indicate that the EGFR can mediate radioresistance in different solid human tumours. Combination of radiotherapy and EGFR inhibitors can improve local tumour control compared to irradiation alone and has been introduced into clinical radiotherapy practice.
Michael, Baumann +6 more
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Preclinical Models for Evaluating Topoisomerase I-Targeted Drugs
2005Type I and II DNA topoisomerases are the targets for numerous clinically efficacious antitumor agents. Over the last decade, considerable effort has been expended in developing camptothecin (CPT) derivatives that selectively target DNA topoisomerase I (TOP-I) (1).
Aarti S. Juvekar +3 more
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Preclinical Drug Evaluation with Human Melanoma Xenografts
1988In 1974 there was an increasing awareness at the National Cancer Institute of the U.S.A. that important drugs might have been missed by the conventional murine tumor screening system then employed. Differences in biochemistry and cell biology of murine vs. human tumors were increasingly well understood.
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The Scientific Basis of Drug-Drug Interactions: Mechanism and Preclinical Evaluation
Drug Information Journal, 1998Pharmacokinetic drug-drug interactions (PDDI), in which the pharmacokinetic clearance of one drug is altered by a coadministered drug, can be divided mechanistically into two general categories: 1. Inhibitory PDDI—the inhibition of the metabolic clearance of one drug by a coadministered drug, and 2.
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Preclinical Evaluation of Cudetaxestat for Potential Drug-Drug Interactions
B36. SPECTRUM OF FIBROTIC INTERSTITIAL LUNG DISEASES, 2022W. Yu +3 more
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ChemInform Abstract: Drug Safety Evaluation at the Preclinical Stage
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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