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Technological Advances in Preclinical Drug Evaluation: The Role of -Omics Methods
Current Medicinal Chemistry, 2020Preclinical drug development is an essential step in the drug development process where the evaluation of new chemical entities occurs. In particular, preclinical drug development phases include deep analysis of drug candidates’ interactions with biomolecules/targets, their safety, toxicity, pharmacokinetics, metabolism by use of assays in vitro and ...
Elitza Markova-Car +2 more
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Preclinical Dose Number and Its Application in Understanding Drug Absorption Risk and Formulation Design for Preclinical Species [PDF]
Molecular Pharmaceutics, 2015 In the drug discovery setting, the ability to rapidly identify drug absorption risk in preclinical species at high doses from easily measured physical properties is desired.
W Peter Wuelfing, Fílippos Kesisoglou
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Evaluation of Nanoparticle Drug-Delivery Systems used in Preclinical Studies
Therapeutic Delivery, 2021Multifunctional nanoparticles have been identified as a promising drug-delivery system for sustainable drug release. The structural and size tunability and disease-targeting ability of nanoparticles have made them more suitable for multiple drug loading and delivery, thereby enhancing therapeutic results through synergistic effects.
Nagaraja Sreeharsha +3 more
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Preclinical evaluation of UC781 microbicide vaginal drug delivery
Drug Delivery and Translational Research, 2011UC781 is a potent nonnucleoside reverse transcriptase inhibitor being investigated as a potential microbicide to prevent transmission of HIV-1 both vaginally and rectally. This study was designed to investigate the in vitro drug release, in vitro permeability/safety, and in vivo pharmacokinetics in rabbits of a vaginal gel prepared with micronized or ...
Meredith R, Clark +3 more
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Bupropion-induced convulsions: Preclinical evaluation of antiepileptic drugs
Epilepsy Research, 2005Bupropion, a unique, non-nicotine smoking cessation aid and an effective antidepressant, is well known to produce seizures following overdosing in humans. However, the experimental background for the usefulness of antiepileptic drugs in the protection against bupropion-induced convulsions has not been established yet.
Piotr, Tutka +4 more
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Treatment of schizophrenia: A clinical and preclinical evaluation of neuroleptic drugs
Pharmacology & Therapeutics, 1993Forty years after the first clinical report on the effectiveness of chlorpromazine in psychiatric patients, neuroleptic drugs are still the most widely used drugs in the treatment of schizophrenia. Indeed, there are no other drugs which have proven to be as effective in the treatment of this severe psychiatric disorder.
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Preclinical evaluation of behavioral deficits following hypnotic drug treatment
Pharmacology Biochemistry and Behavior, 1986Most hypnotic medications result in performance decrements, or "hangover effects," the morning after bedtime ingestion. However, the severity of hangover effects with new compounds is difficult to predict prior to clinical trials. This paper describes a preclinical procedure that is predictive of human hangover effects following bedtime ingestion of ...
J M, Halperin, J, Canon, L C, Iorio
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Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation
Journal of Pharmacological and Toxicological Methods, 2005The human ether-a-go-go-related gene (hERG) potassium channel plays a major role in the electrical conductances involved in human heart repolarization. Drugs that decrease hERG K(+) currents are at risk to produce a prolongation of the cardiac action potential, resulting in an increase of the QT interval.
Liang, Guo, Heather, Guthrie
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