Results 281 to 290 of about 303,204 (352)

Nanobody Therapeutics in Alzheimer's Disease: From Molecular Mechanisms to Translational Approaches. [PDF]

Antibodies (Basel)
Godugu D, Gattu K, Suri P, Daartey AB, Jadhav K, Rojekar S.   +5 more
europepmc   +1 more source

Supplementary Fig.S3 from Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for treatment of Nectin-4-expressing Cancers

Wei Zhou, Peng Fang, Dongan Yu, Hongyuan Ren, Meng You, Long Yin, Fei Mei, Huikai Zhu, Zhenzhen Wang, Hui Xu, Yuxia Cao, Xiaowei Sun, Xiaohong Xu, Jianjun Bi, Jin Wang, Lanping Ma, Xin Wang, Lin Chen, Yongliang Zhang, Xiaowei Cen, Xi Zhu, Liguang Lou, Datao Liu, Xiaoding Tan, Jinliang Yang, Tao Meng, Jingkang Shen   +26 more
openalex   +1 more source

Autonomous Hydrogel Actuators Programmed by Endogenous Biochemical Logic for Dual‐Stage Morphing and Drug Release

Advanced Materials, EarlyView.
A 3D‐printed BSA–PEGDA bilayer actuator performs biochemical logic, bending autonomously in acid and releasing its drug payload only when both acid and pepsin are present. This dual‐stage, enzyme‐gated mechanism enables autonomous catch‐and‐release motion and controlled gastric drug delivery, representing a programmable soft material powered by ...
Yuchen Liu, Harischandra Potthuri, Alejandro Sosnik, Luai R. Khoury   +3 more
wiley   +1 more source

Design and synthesis of natural antibacterial derivatives for ocular tuberculosis: a comprehensive review. [PDF]

Front Pharmacol
Osei Duah I, Amankwah G, Ampong J, Brown S, Tettey BL, Acheampong HO, Awuku RB, Danquah CA.   +7 more
europepmc   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Minimally invasive steam-assisted drug delivery with ICG fluorescence guidance for primary malignant bone tumors and evaluation of clinical applicability. [PDF]

PLoS One
Lee SM, Yoon K, Lee S, Kang HG, Kim KG.
europepmc   +1 more source

Phosphatidylinositol-3-Kinase (PI3K) and Histone Deacetylase (HDAC) Multitarget Inhibitors: An Update on Clinical and Preclinical Candidates. [PDF]

Pharmaceuticals (Basel)
Lima ADS, Lima LM.
europepmc   +1 more source

Smart Antidiabetic Nanomedicine: A Revolutionized Therapeutic Approach for Treatment of Diabetes Mellitus. [PDF]

Bioengineering (Basel)
Mohammad Karim A.
europepmc   +1 more source

Figure 4 from Preclinical Evaluation of STI-8811, a Novel Antibody–Drug Conjugate Targeting BCMA for the Treatment of Multiple Myeloma

Aaron D. Springer, Rengang Wang, Jiawei Wang, Qinyi Du, Willie Pi, Austin Q. Nguyen, Xiaoqing Li, Alisher Khasanov, Tong Zhu, Zheng Yan, Yufeng Hong, Heyue Zhou, Yanliang Zhang, Lisa Kerwin, Lingna Li, Henry Ji, Hong Zhang   +16 more
openalex   +1 more source

Targeting Cancer Stem Cells with Phytochemicals: Molecular Mechanisms and Therapeutic Potential. [PDF]

Biomedicines
Sah AK, Das J, Umarovich AI, Agarwal S, Prabhakar PK, Vashishtha A, Elshaikh RH, Choudhary RK, Alfeel AH.   +8 more
europepmc   +1 more source