Results 291 to 300 of about 1,044,728 (382)

A Modular Perfusion Bioreactor Platform for Simulating Bone Regeneration and Fracture Healing: Integrating Mechanical Loading and Dual Perfusion for Advanced In Vitro Models

Advanced Healthcare Materials, EarlyView.
A modular bioreactor platform was developed in order to replicate bone homeostasis and pathology, thereby integrating mechanical loading, dynamic perfusion, and a 3D‐printed microfluidic chamber. With precise control of environmental parameters and dual perfusion for composite tissue models, the system enhances physiological relevance for studying bone
Moritz Pfeiffenberger, Alexandra Damerau, Johannes Plank, Adel Ahmed, Mario Thiele, Jan Saam, Paula Hoff, Timo Gaber, Frank Buttgereit   +8 more
wiley   +1 more source

From data silos to insights: the PRINCE multi-agent knowledge engine for preclinical drug development. [PDF]

Front Artif Intell
Vieira-Vieira CH, Kulkarni SS, Zalewski A, Löffler J, Münch J, Kreuchwig A.   +5 more
europepmc   +1 more source

Preclinical Evaluation of STI-8811, a Novel Antibody Drug Conjugate Targeting BCMA for the Treatment of Multiple Myeloma

Aaron D. Springer, Rengang Wang, Jiawei Wang, Qinyi Du, Willie Pi, Austin Q. Nguyen, Xiaoqing Li, Alisher Khasanov, Tong Zhu, Zheng Yan, Yufeng Hong, Heyue Zhou, Yanliang Zhang, Lisa Kerwin, Lingna Li, Henry Ji, Hong Zhang   +16 more
openalex   +1 more source

Cyclic Peptide–Polymer Conjugate Nanotubes for Delivery of SN‐38 in Treatment of Colorectal Cancer Model

Advanced Healthcare Materials, EarlyView.
This study develops cyclic peptidepolymer conjugate nanotubes with hydrophobic, drug‐rich cores to enhance drug loading and stability, and demonstrates their responsive disassembly, pharmacokinetics, and anti‐tumour efficacy in colorectal cancer models using the anticancer drug SN‐38.
Sophie K. Hill, Min Zeng, Santhosh Kalash Rajendrakumar, Robert Dallmann, Sébastien Perrier   +4 more
wiley   +1 more source

Thyroid Cancer Risk and the Next Generation of Diabetes Drugs: What Can We Learn from Incretin-Based Therapies? [PDF]

Endocrinol Metab (Seoul)
Son H, Cho SW.
europepmc   +1 more source

Transforming Cancer Diagnosis and Therapy Through Fluorescent Hydrogels: A Review

Advanced Healthcare Materials, EarlyView.
This article reviews fluorescent hydrogel systems for cancer detection, monitoring, and therapy. Mimicking the tumor microenvironment, these hydrogels enable real‐time imaging and targeted drug delivery. The review discusses design strategies, labeling techniques, and applications, highlighting challenges and future opportunities in cancer diagnostics ...
Elahe Masaeli, Seshasai Srinivasan, Amin Reza Rajabzadeh   +2 more
wiley   +1 more source

Figure 2 from Preclinical Evaluation of STI-8811, a Novel Antibody–Drug Conjugate Targeting BCMA for the Treatment of Multiple Myeloma

Aaron D. Springer, Rengang Wang, Jiawei Wang, Qinyi Du, Willie Pi, Austin Q. Nguyen, Xiaoqing Li, Alisher Khasanov, Tong Zhu, Zheng Yan, Yufeng Hong, Heyue Zhou, Yanliang Zhang, Lisa Kerwin, Lingna Li, Henry Ji, Hong Zhang   +16 more
openalex   +1 more source

Current Challenges in Hemostasis and Advances in Particle‐Assisted Styptic Devices

Advanced Healthcare Materials, EarlyView.
Here persistent limitations in hemostatic technologies are highlighted and cutting‐edge biomimetic, microparticle‐assisted, and nanoengineered systems with integrated drug delivery are showcased. Moreover, the article identifies fresh directions toward the next‐generation of multifunctional hemostatic devices with superior efficacy and accessibility ...
Daniele Baiocco, Zhibing Zhang, Neil M. Eisenstein, Nigel Tai, Liam M. Grover   +4 more
wiley   +1 more source

Drosophila melanogaster as a rapid in vivo assay system for preclinical anti-seizure medication testing. [PDF]

Epilepsia Open
Töfflinger EV, Makridis KL, Heim MM, Owald D, Kaindl AM.   +4 more
europepmc   +1 more source

Table 1 from Preclinical Evaluation of STI-8811, a Novel Antibody–Drug Conjugate Targeting BCMA for the Treatment of Multiple Myeloma

Aaron D. Springer, Rengang Wang, Jiawei Wang, Qinyi Du, Willie Pi, Austin Q. Nguyen, Xiaoqing Li, Alisher Khasanov, Tong Zhu, Zheng Yan, Yufeng Hong, Heyue Zhou, Yanliang Zhang, Lisa Kerwin, Lingna Li, Henry Ji, Hong Zhang   +16 more
openalex   +1 more source