Results 41 to 50 of about 6,725,081 (364)

Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner

Frontiers in Medicine, 2019
Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing radiation. CT doses in pre-clinical in vivo imaging typically range from 50 to 1,000 mGy and biological effects in mice at this dose ...
Cesar Molinos, Todd Sasser, Phil Salmon, Willy Gsell, David Viertl, James C. Massey, Krzysztof Mińczuk, Jie Li, Bijoy K. Kundu, Stuart Berr, Carlos Correcher, Ali Bahadur, Ali A. Attarwala, Simon Stark, Sven Junge, Uwe Himmelreich, John O. Prior, Kjell Laperre, Sonica Van Wyk, Michael Heidenreich   +19 more
doaj   +1 more source

Elevated Monoamine Oxidase-A in Anterior Cingulate of Post-Mortem Human Parkinson’s Disease: A Potential Surrogate Biomarker for Lewy Bodies?

Cells, 2022
Lewy bodies (LB) play a neuropathological role in Parkinson’s disease (PD). Our goal was to evaluate LB using anti-ubiquitin immunohistochemistry (UIHC) and find correlations with monoamine oxidase-A (MAO-A) using imaging agent, [18F]FAZIN3.
Jogeshwar Mukherjee, Reisha M. Ladwa, Christopher Liang, Amina U. Syed   +3 more
doaj   +1 more source

Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance [PDF]

, 2015
Small-animal imaging has become an important technique for the development of new radiotracers, drugs and therapies. Many laboratories have now a combination of different small-animal imaging systems, which are being used by biologists, pharmacists ...
Bankstahl, Jens, Belcari, Nicola, Krämer, Stefanie, Vandenberghe, Stefaan, Vanhove, Christian, Visser, Eric   +5 more
core   +1 more source

Semi-automated Image Processing for Preclinical Bioluminescent Imaging [PDF]

Journal of Applied Bioinformatics & Computational Biology, 2015
Bioluminescent imaging is a valuable noninvasive technique for investigating tumor dynamics and specific biological molecular events in living animals to better understand the effects of human disease in animal models. The purpose of this study was to develop and test a strategy behind automated methods for bioluminescence image processing from the ...
Nikolai V, Slavine, Roderick W, McColl
openaire   +2 more sources

5th Internatinal TPCF Preclinical Imaging Symposium

Frontiers in Biomedical Technologies, 2023
Preclinical imaging is the visualization of living animals for research purposes, such as drug development. Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in ...
5th Internatinal TPCF Preclinical Imaging
doaj  

Lossy Image Compression in a Preclinical Multimodal Imaging Study

Journal of Digital Imaging, 2023
AbstractThe growing use of multimodal high-resolution volumetric data in pre-clinical studies leads to challenges related to the management and handling of the large amount of these datasets. Contrarily to the clinical context, currently there are no standard guidelines to regulate the use of image compression in pre-clinical contexts as a potential ...
Francisco F. Cunha, Valentin Blüml, Lydia M. Zopf, Andreas Walter, Michael Wagner, Wolfgang J. Weninger, Lucas A. Thomaz, Luís M. N. Tavora, Luis A. da Silva Cruz, Sergio M. M. Faria   +9 more
openaire   +3 more sources

Dimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation

EJNMMI Research, 2022
Highlights In a focal rat DTH-EAE model of neuroinflammation, dimethyl fumarate decreases the uptake of TSPO PET tracer [18F]GE-180 in the short term. Long-term [18F]GE-180 follow-up did not indicate a treatment effect.
S. K. Vainio, A. M. Dickens, M. Matilainen, F. R. López-Picón, R. Aarnio, O. Eskola, O. Solin, D. C. Anthony, J. O. Rinne, L. Airas, M. Haaparanta-Solin   +10 more
doaj   +1 more source

Preclinical and exploratory human studies of novel 68Ga-labeled D-peptide antagonist for PET imaging of TIGIT expression in cancers

European Journal of Nuclear Medicine and Molecular Imaging, 2022
While TIGIT has been propelled as a next-generation target in cancer immunotherapy, anti-TIGIT therapy seems to be promising for a fraction of patients in clinical trials.
Xiaobo Wang, Ming Zhou, Bei Chen, Huanhuan Liu, Jianyang Fang, Shijun Xiang, Shuo Hu, Xianzhong Zhang   +7 more
semanticscholar   +1 more source

[¹²⁵I]INFT: Synthesis and Evaluation of a New Imaging Agent for Tau Protein in Post-Mortem Human Alzheimer’s Disease Brain

Molecules, 2023
Aggregation of Tau protein into paired helical filaments causing neurofibrillary tangles (NFT) is a neuropathological feature in Alzheimer’s disease (AD).
Roz R. Limpengco, Christopher Liang, Yasmin K. Sandhu, Jogeshwar Mukherjee   +3 more
doaj   +1 more source

Preclinical Imaging Biomarkers for Postischaemic Neurovascular Remodelling. [PDF]

Contrast Media Mol Imaging, 2019
In the pursuit of understanding the pathological alterations that underlie ischaemic injuries, such as vascular remodelling and reorganisation, there is a need for recognising the capabilities and limitations of in vivo imaging techniques. Thus, this review presents contemporary published research of imaging modalities that have been implemented to ...
Gandhi R, Tsoumpas C.
europepmc   +4 more sources