Results 41 to 50 of about 6,433,487 (363)

Preclinical and Translational PET/MR Imaging [PDF]

Journal of Nuclear Medicine, 2014
Combined PET and MR imaging (PET/MR imaging) has progressed tremendously in recent years. The focus of current research has shifted from technologic challenges to the application of this new multimodal imaging technology in the areas of oncology, cardiology, neurology, and infectious diseases.
Wolfgang M. Thaiss, Wolfgang M. Thaiss, Hans F. Wehrl, Stefan Wiehr, Johannes Schwenck, Johannes Schwenck, Bernd J. Pichler, Florian Maier, Grant T. Gullberg, Grant T. Gullberg, Anna-Maria Rolle, Mathew R. Divine, Sergios Gatidis   +12 more
openaire   +4 more sources

Low-Dose Imaging in a New Preclinical Total-Body PET/CT Scanner

Frontiers in Medicine, 2019
Ionizing radiation constitutes a health risk to imaging scientists and study animals. Both PET and CT produce ionizing radiation. CT doses in pre-clinical in vivo imaging typically range from 50 to 1,000 mGy and biological effects in mice at this dose ...
Cesar Molinos, Todd Sasser, Phil Salmon, Willy Gsell, David Viertl, James C. Massey, Krzysztof Mińczuk, Jie Li, Bijoy K. Kundu, Stuart Berr, Carlos Correcher, Ali Bahadur, Ali A. Attarwala, Simon Stark, Sven Junge, Uwe Himmelreich, John O. Prior, Kjell Laperre, Sonica Van Wyk, Michael Heidenreich   +19 more
doaj   +1 more source

Elevated Monoamine Oxidase-A in Anterior Cingulate of Post-Mortem Human Parkinson’s Disease: A Potential Surrogate Biomarker for Lewy Bodies?

Cells, 2022
Lewy bodies (LB) play a neuropathological role in Parkinson’s disease (PD). Our goal was to evaluate LB using anti-ubiquitin immunohistochemistry (UIHC) and find correlations with monoamine oxidase-A (MAO-A) using imaging agent, [18F]FAZIN3.
Jogeshwar Mukherjee, Reisha M. Ladwa, Christopher Liang, Amina U. Syed   +3 more
doaj   +1 more source

4th Internatinal TPCF Preclinical Imaging Symposium

Frontiers in Biomedical Technologies, 2021
Due to the huge costs and time spent for development of new drugs (around almost $ 1 billion (USD) and 12 Years), investing on the preclinical phase of drug development could be regarded as a great investment for de-risking the clinical phases ...
4th Internatinal TPCF Preclinical Imaging
doaj  

Dimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation

EJNMMI Research, 2022
Highlights In a focal rat DTH-EAE model of neuroinflammation, dimethyl fumarate decreases the uptake of TSPO PET tracer [18F]GE-180 in the short term. Long-term [18F]GE-180 follow-up did not indicate a treatment effect.
S. K. Vainio, A. M. Dickens, M. Matilainen, F. R. López-Picón, R. Aarnio, O. Eskola, O. Solin, D. C. Anthony, J. O. Rinne, L. Airas, M. Haaparanta-Solin   +10 more
doaj   +1 more source

5th Internatinal TPCF Preclinical Imaging Symposium

Frontiers in Biomedical Technologies, 2023
Preclinical imaging is the visualization of living animals for research purposes, such as drug development. Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in ...
5th Internatinal TPCF Preclinical Imaging
doaj  

Accurate and fast deep learning dose prediction for a preclinical microbeam radiation therapy study using low-statistics Monte Carlo simulations [PDF]

Cancers 2023, 15(7), 2137, 2022
Microbeam radiation therapy (MRT) utilizes coplanar synchrotron radiation beamlets and is a proposed treatment approach for several tumour diagnoses that currently have poor clinical treatment outcomes, such as gliosarcomas. Prescription dose estimations for treating preclinical gliosarcoma models in MRT studies at the Imaging and Medical Beamline at ...
arxiv   +1 more source

Clinical utility of cerebrospinal fluid biomarkers measured by LUMIPULSE® system

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1898-1909, December 2022., 2022
Abstract Objectives Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are well‐established in research settings, but their use in routine clinical practice remains a largely unexploited potential. Here, we examined the relationship between CSF biomarkers, measured by a fully automated immunoassay platform, and brain β‐amyloid (Aβ ...
Hisashi Nojima, Satoshi Ito, Akira Kushida, Aki Abe, Wataru Motsuchi, David Verbel, Manu Vandijck, Geert Jannes, Ina Vandenbroucke, Katsumi Aoyagi   +9 more
wiley   +1 more source

Evaluation of Precision in Optoacoustic Tomography for Preclinical Imaging in Living Subjects

Journal of Nuclear Medicine, 2017
Optoacoustic tomography (OT) is now widely used in preclinical imaging; however, the precision (repeatability and reproducibility) of OT has yet to be determined. Methods: We used a commercial small-animal OT system.
J. Joseph, M. Tomaszewski, I. Quiros-Gonzalez, Judith Weber, J. Brunker, S. Bohndiek   +5 more
semanticscholar   +1 more source

Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022
Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh, Rachel S. Kasper, Jessie Sanford, Chia‐Ling Phuah, Jason Hassenstab, Carlos Cruchaga   +5 more
wiley   +1 more source