Results 51 to 60 of about 6,433,487 (363)
Scientific Reports, 2021 Exposure to antibiotic treatment has been associated with increased vulnerability to various psychiatric disorders. However, a research gap exists in understanding how adolescent antibiotic therapy affects behavior and cognition.
Anouk C. Tengeler +7 more
doaj +1 more source
XNAT-PIC: Extending XNAT to Preclinical Imaging Centers [PDF]
arXiv, 2021 Molecular imaging generates large volumes of heterogeneous biomedical imagery with an impelling need of guidelines for handling image data. Although several successful solutions have been implemented for human epidemiologic studies, few and limited approaches have been proposed for animal population studies.
arxiv
Communications Biology, 2022 Nuclear magnetic resonance spectroscopy-based tissue metabolomics is used to define detailed temporal signatures of acute and chronic inflammation in cutaneous delayed-type hypersensitivity reaction.
Laimdota Zizmare +7 more
doaj +1 more source
[124I]IBETA: A New Aβ Plaque Positron Emission Tomography Imaging Agent for Alzheimer’s Disease
Molecules, 2022 Several fluorine-18-labeled PET β-amyloid (Aβ) plaque radiotracers for Alzheimer’s disease (AD) are in clinical use. However, no radioiodinated imaging agent for Aβ plaques has been successfully moved forward for either single-photon emission computed ...
Grace A.H. Nguyen +2 more
doaj +1 more source
Evaluating U-net Brain Extraction for Multi-site and Longitudinal Preclinical Stroke Imaging [PDF]
arXiv, 2022 Rodent stroke models are important for evaluating treatments and understanding the pathophysiology and behavioral changes of brain ischemia, and magnetic resonance imaging (MRI) is a valuable tool for measuring outcome in preclinical studies. Brain extraction is an essential first step in most neuroimaging pipelines; however, it can be challenging in ...
arxiv
Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease
Molecular Medicine, 2021 Parkinson’s disease (PD) commences several years before the onset of motor features. Pathophysiological understanding of the pre-clinical or early prodromal stages of PD are essential for the development of new therapeutic strategies.
S. Meles, W. Oertel, K. Leenders
semanticscholar +1 more source
Intratumoral in vivo staging of breast cancer by multi-tracer PET and advanced analysis
npj Breast Cancer, 2022 The staging and local management of breast cancer involves the evaluation of the extent and completeness of excision of both the invasive carcinoma component and also the intraductal component or ductal carcinoma in situ.
Jennifer Griessinger +16 more
doaj +1 more source
Pharmaceutics, 2021 P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are co-localized at the blood–brain barrier, where they display functional redundancy to restrict the brain distribution of dual P-gp/BCRP substrate drugs.
Irene Hernández-Lozano +8 more
doaj +1 more source
Computational Image-based Stroke Assessment for Evaluation of Cerebroprotectants with Longitudinal and Multi-site Preclinical MRI [PDF]
arXiv, 2022 While ischemic stroke is a leading cause of death worldwide, there has been little success translating putative cerebroprotectants from rodent preclinical trials to human patients. We investigated computational image-based assessment tools for practical improvement of the quality, scalability, and outlook for large scale preclinical screening for ...
arxiv
Molecules, 2022 A large number of applications for fibroblast activation protein inhibitors (FAPI)-based PET agents have been evaluated in conditions ranging from cancer to non-malignant diseases such as myocardial infarction. In particular, 68Ga-FAPI-46 was reported to
Chiara Da Pieve +6 more
doaj +1 more source