Synthesis, Preclinical Evaluation, and a Pilot Clinical PET Imaging Study of 68Ga-Labeled FAPI Dimer
Journal of Nuclear Medicine, 2021 Visual Abstract Cancer-associated fibroblasts (CAFs) are crucial components of the tumor microenvironment. Fibroblast activation protein (FAP) is overexpressed in CAFs. FAP-targeted molecular imaging agents, including the FAP inhibitors (FAPIs) 04 and 46,
Liang Zhao +10 more
semanticscholar +1 more source
Preclinical and Translational PET/MR Imaging [PDF]
Journal of Nuclear Medicine, 2014 Combined PET and MR imaging (PET/MR imaging) has progressed tremendously in recent years. The focus of current research has shifted from technologic challenges to the application of this new multimodal imaging technology in the areas of oncology, cardiology, neurology, and infectious diseases.
H. F. Wehrl +9 more
openaire +2 more sources
Reflections on the Utility of the Retina as a Biomarker for Alzheimer's Disease: A Literature Review. [PDF]
, 2019 As a part of the central nervous system, the retina may reflect both physiologic processes and abnormalities related to diseases of the brain. Indeed, a concerted effort has been put forth to understand how Alzheimer's disease (AD) pathology may manifest
Honma, Patrick +2 more
core +1 more source
Early affective changes and increased connectivity in preclinical Alzheimer's disease. [PDF]
, 2018 IntroductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli.
Bilgel, Murat +7 more
core +1 more source
Whole-Body Photoacoustic Imaging Techniques for Preclinical Small Animal Studies
Italian National Conference on Sensors, 2022 Photoacoustic imaging is a hybrid imaging technique that has received considerable attention in biomedical studies. In contrast to pure optical imaging techniques, photoacoustic imaging enables the visualization of optical absorption properties at deeper
Hyunjun Kye +4 more
semanticscholar +1 more source
Brain amyloid in preclinical Alzheimer\u27s disease is associated with increased driving risk [PDF]
, 2016 INTRODUCTION: Postmortem studies suggest that fibrillar brain amyloid places people at higher risk for hazardous driving in the preclinical stage of Alzheimer's disease (AD). METHODS: We administered driving questionnaires to 104 older drivers (19 AD, 24
Bernier, Justine N +7 more
core +2 more sources
Optimizing dual energy cone beam CT protocols for preclinical imaging and radiation research [PDF]
, 2017 Objective: The aim of this work was to investigate whether quantitative dual-energy CT (DECT) imaging is feasible for small animal irradiators with an integrated cone-beam CT (CBCT) system.
Almeida, Isabel P +7 more
core +1 more source
Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease
Molecular Medicine, 2021 Parkinson’s disease (PD) commences several years before the onset of motor features. Pathophysiological understanding of the pre-clinical or early prodromal stages of PD are essential for the development of new therapeutic strategies.
S. Meles, W. Oertel, K. Leenders
semanticscholar +1 more source
Scientific Reports, 2021 Exposure to antibiotic treatment has been associated with increased vulnerability to various psychiatric disorders. However, a research gap exists in understanding how adolescent antibiotic therapy affects behavior and cognition.
Anouk C. Tengeler +7 more
doaj +1 more source
GBM radiosensitizers: dead in the water…or just the beginning? [PDF]
, 2017 The finding that most GBMs recur either near or within the primary site after radiotherapy has fueled great interest in the development of radiosensitizers to enhance local control.
Bindra, Ranjit S. +3 more
core +1 more source