Results 61 to 70 of about 6,433,487 (363)

Lossy Image Compression in a Preclinical Multimodal Imaging Study

Journal of Digital Imaging, 2023
AbstractThe growing use of multimodal high-resolution volumetric data in pre-clinical studies leads to challenges related to the management and handling of the large amount of these datasets. Contrarily to the clinical context, currently there are no standard guidelines to regulate the use of image compression in pre-clinical contexts as a potential ...
Francisco F. Cunha, Valentin Blüml, Lydia M. Zopf, Andreas Walter, Michael Wagner, Wolfgang J. Weninger, Lucas A. Thomaz, Luís M. N. Tavora, Luis A. da Silva Cruz, Sergio M. M. Faria   +9 more
openaire   +2 more sources

Double diffusion encoding and applications for biomedical imaging [PDF]

Journal of Neuroscience Methods (2020), 2020
Diffusion Magnetic Resonance Imaging (dMRI) is one of the most important contemporary non-invasive modalities for probing tissue structure at the microscopic scale. The majority of dMRI techniques employ standard single diffusion encoding (SDE) measurements, covering different sequence parameter ranges depending on the complexity of the method ...
arxiv   +1 more source

The Use of Ostrich Eggs for In Ovo Research: Making Preclinical Imaging Research Affordable and Available

Journal of Nuclear Medicine, 2018
In ovo studies are a valuable option in preclinical research, but imaging studies are severely limited by the costs of dedicated equipment needed for small-sized eggs.
M. Freesmeyer, C. Kuehnel, T. Opfermann, T. Niksch, S. Wiegand, R. Stolz, R. Huonker, O. Witte, T. Winkens   +8 more
semanticscholar   +1 more source

3rd TPCF Preclinical Symposium Imaging(TPIS 2020)

Frontiers in Biomedical Technologies, 2020
The path of discovering/designing a molecule to developing a novel drug could take up to an average of 12 years and costs around $1 billion (USD). Preclinical phase is a major step on this path and is the part where scientists perform additional studies ...
3rd TPCF Preclinical Symposium Imaging (TPIS 2020)
doaj  

Brain and Brown Adipose Tissue Metabolism in Transgenic Tg2576 Mice Models of Alzheimer Disease Assessed Using F-FDG PET Imaging

Molecular Imaging, 2017
Objective: Imaging animal models of Alzheimer disease (AD) is useful for the development of therapeutic drugs and understanding AD. Transgenic Swedish hAPPswe Tg2576 mice are a good model of β-amyloid plaques.
Robert A. Coleman PhD, Christopher Liang BS, Rima Patel BS, Sarah Ali BS, Jogeshwar Mukherjee PhD   +4 more
doaj   +1 more source

Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors

Molecular Cancer, 2023
Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L1) expression
Philipp Knopf, Dimitri Stowbur, Sabrina H. L. Hoffmann, Natalie Hermann, Andreas Maurer, Valentina Bucher, Marilena Poxleitner, Bredi Tako, Dominik Sonanini, Balaji Krishnamachary, Sanhita Sinharay, Birgit Fehrenbacher, Irene Gonzalez-Menendez, Felix Reckmann, David Bomze, Lukas Flatz, Daniela Kramer, Martin Schaller, Stephan Forchhammer, Zaver M. Bhujwalla, Leticia Quintanilla-Martinez, Klaus Schulze-Osthoff, Mark D. Pagel, Marieke F. Fransen, Martin Röcken, André F. Martins, Bernd J. Pichler, Kamran Ghoreschi, Manfred Kneilling   +28 more
doaj   +1 more source

Gelatin-based Hydrogel Degradation and Tissue Interaction in vivo: Insights from Multimodal Preclinical Imaging in Immunocompetent Nude Mice

Theranostics, 2016
Hydrogels based on gelatin have evolved as promising multifunctional biomaterials. Gelatin is crosslinked with lysine diisocyanate ethyl ester (LDI) and the molar ratio of gelatin and LDI in the starting material mixture determines elastic properties of ...
C. Tondera, S. Hauser, A. Krüger-Genge, F. Jung, A. Neffe, A. Lendlein, R. Klopfleisch, J. Steinbach, Christin Neuber, Jens Pietzsch   +9 more
semanticscholar   +1 more source

Semi-automated Image Processing for Preclinical Bioluminescent Imaging [PDF]

Journal of Applied Bioinformatics & Computational Biology, 2015
Bioluminescent imaging is a valuable noninvasive technique for investigating tumor dynamics and specific biological molecular events in living animals to better understand the effects of human disease in animal models. The purpose of this study was to develop and test a strategy behind automated methods for bioluminescence image processing from the ...
Roderick W McColl, Nikolai V Slavine
openaire   +3 more sources

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

A System-Agnostic, Adaptable and Extensible Animal Support Cradle System for Cardio-Respiratory-Synchronised, and Other, Multi-Modal Imaging of Small Animals

Tomography, 2021
Standardisation of animal handling procedures for a wide range of preclinical imaging scanners will improve imaging performance and reproducibility of scientific data.
Veerle Kersemans, Stuart Gilchrist, Philip Danny Allen, Sheena Wallington, Paul Kinchesh, John Prentice, Martin Tweedie, Jamie H. Warner, Sean C. Smart   +8 more
doaj   +1 more source