Results 61 to 70 of about 6,725,081 (364)

Elucidating the complementarity of resting-state networks derived from dynamic [18F]FDG and hemodynamic fluctuations using simultaneous small-animal PET/MRI

NeuroImage, 2021
Functional connectivity (FC) and resting-state network (RSN) analyses using functional magnetic resonance imaging (fMRI) have evolved into a growing field of research and have provided useful biomarkers for the assessment of brain function in ...
Tudor M. Ionescu, Mario Amend, Rakibul Hafiz, Bharat B. Biswal, Hans F. Wehrl, Kristina Herfert, Bernd J. Pichler   +6 more
doaj   +1 more source

Preclinical translation of exosomes derived from mesenchymal stem/stromal cells. [PDF]

, 2020
Exosomes are nanovesicles secreted by virtually all cells. Exosomes mediate the horizontal transfer of various macromolecules previously believed to be cell-autonomous in nature, including nonsecretory proteins, various classes of RNA, metabolites, and ...
Anderson, Johnathon D, Elahi, Fanny M, Farwell, D Gregory, Nolta, Jan A   +3 more
core  

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. [PDF]

, 2014
Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon ...
Beckerle, Mary C, Chaturvedi, Aashi, Grossmann, Allie H, Hoffman, Laura M, Jensen, Christopher C, Lessnick, Stephen L, Lin, Yi-Chun, Randall, R Lor, Welm, Alana L   +8 more
core   +1 more source

Acute and chronic inflammation alter immunometabolism in a cutaneous delayed-type hypersensitivity reaction (DTHR) mouse model

Communications Biology, 2022
Nuclear magnetic resonance spectroscopy-based tissue metabolomics is used to define detailed temporal signatures of acute and chronic inflammation in cutaneous delayed-type hypersensitivity reaction.
Laimdota Zizmare, Roman Mehling, Irene Gonzalez-Menendez, Caterina Lonati, Leticia Quintanilla-Martinez, Bernd J. Pichler, Manfred Kneilling, Christoph Trautwein   +7 more
doaj   +1 more source

[¹²⁴I]IBETA: A New Aβ Plaque Positron Emission Tomography Imaging Agent for Alzheimer’s Disease

Molecules, 2022
Several fluorine-18-labeled PET β-amyloid (Aβ) plaque radiotracers for Alzheimer’s disease (AD) are in clinical use. However, no radioiodinated imaging agent for Aβ plaques has been successfully moved forward for either single-photon emission computed ...
Grace A.H. Nguyen, Christopher Liang, Jogeshwar Mukherjee   +2 more
doaj   +1 more source

Sensitive and specific detection of breast cancer lymph node metastasis through dual-modality magnetic particle imaging and fluorescence molecular imaging: a preclinical evaluation

European Journal of Nuclear Medicine and Molecular Imaging, 2021
A sensitive and specific imaging method to detect metastatic cancer cells in lymph nodes to detect the early-stage breast cancer is still a challenge.
Guorong Wang, Wenzhe Li, Guang-Jin Shi, Yu Tian, Ling-yan Kong, N. Ding, Jing Lei, Zhengyu Jin, Jie Tian, Yang Du   +9 more
semanticscholar   +1 more source

3rd TPCF Preclinical Symposium Imaging(TPIS 2020)

Frontiers in Biomedical Technologies, 2020
The path of discovering/designing a molecule to developing a novel drug could take up to an average of 12 years and costs around $1 billion (USD). Preclinical phase is a major step on this path and is the part where scientists perform additional studies ...
3rd TPCF Preclinical Symposium Imaging (TPIS 2020)
doaj  

Brain and Brown Adipose Tissue Metabolism in Transgenic Tg2576 Mice Models of Alzheimer Disease Assessed Using F-FDG PET Imaging

Molecular Imaging, 2017
Objective: Imaging animal models of Alzheimer disease (AD) is useful for the development of therapeutic drugs and understanding AD. Transgenic Swedish hAPPswe Tg2576 mice are a good model of β-amyloid plaques.
Robert A. Coleman PhD, Christopher Liang BS, Rima Patel BS, Sarah Ali BS, Jogeshwar Mukherjee PhD   +4 more
doaj   +1 more source

Intratumoral in vivo staging of breast cancer by multi-tracer PET and advanced analysis

npj Breast Cancer, 2022
The staging and local management of breast cancer involves the evaluation of the extent and completeness of excision of both the invasive carcinoma component and also the intraductal component or ductal carcinoma in situ.
Jennifer Griessinger, Julian Schwab, Qian Chen, Anna Kühn, Jonathan Cotton, Gregory Bowden, Heike Preibsch, Gerald Reischl, Leticia Quintanilla-Martinez, Hidetoshi Mori, An Nguyen Dang, Ursula Kohlhofer, Olulanu H. Aina, Alexander D. Borowsky, Bernd J. Pichler, Robert D. Cardiff, Andreas M. Schmid   +16 more
doaj   +1 more source

Assessing the Functional Redundancy between P-gp and BCRP in Controlling the Brain Distribution and Biliary Excretion of Dual Substrates with PET Imaging in Mice

Pharmaceutics, 2021
P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are co-localized at the blood–brain barrier, where they display functional redundancy to restrict the brain distribution of dual P-gp/BCRP substrate drugs.
Irene Hernández-Lozano, Severin Mairinger, Alexander Traxl, Michael Sauberer, Thomas Filip, Johann Stanek, Claudia Kuntner, Thomas Wanek, Oliver Langer   +8 more
doaj   +1 more source