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Preclinical PET imaging study of lung cancer with 64CuCl2
Annals of Nuclear Medicine, 2020Human copper transporter 1 (CTR1) has been proven to be overexpressed in many types of cancer cells, and copper (II)-64 chloride (64CuCl2) has been used as an effective tracer for positron emission tomography (PET) imaging in tumor-bearing animal models.
Qiang Wang +4 more
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Preclinical PET and SPECT for Radionanomedicine
2018Quantitative evaluation of in vivo biodistribution is a prerequisite for the development of new targeted theranostic probes in nanomedicine. Here in this chapter the principles of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) were explained. These two modalities are now popularly used for small animal studies
Hyung-Jun Im, Gi Jeong Cheon
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Preclinical Molecular Imaging Using PET and MRI
2012Molecular imaging fundamentally changes the way we look at cancer. Imaging paradigms are now shifting away from classical morphological measures towards the assessment of functional, metabolic, cellular, and molecular information in vivo. Interdisciplinary driven developments of imaging methodology and probe molecules utilizing animal models of human ...
Gunter, Wolf, Nasreddin, Abolmaali
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Dual-Modality Preclinical SPECT/PET Instrumentation
2014Present multimodality imaging strategies are mostly based on the combination of complementary imaging technique such as PET/CT and SPECT/CT where functional and morphological information on the same subject can be derived and combined. On the shadow of the successful application of combined PET/CT scanners in the clinical environment, multimodality ...
DEL GUERRA, ALBERTO, BELCARI, NICOLA
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Pharmacological Prerequisites for PET Ligands and Practical Issues in Preclinical PET Research
2006The development of PET radiopharmaceuticals for the non-invasive imaging of cancerous lesions, brain receptors, transporters and enzymes started more than 25 years ago. But till today no established algorithms exist to predict the success of a PET radiopharmaceutical.
Ametamey SM, Honer M
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Optimizing SUV Analysis: A Multicenter Study on Preclinical FDG-PET/CT Highlights the Impact of Standardization [PDF]
Molecular Imaging and Biology: Purpose Preclinical imaging, with translational potential, lacks a standardized method for defining volumes of interest (VOIs), impacting data reproducibility.
Claudia Kuntner +2 more
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Preclinical tools in PET-tracer development
2010PET (Positronen Emmissions Tomographie) ist eine innovative Technik zur Visualisierung und Quantifizierung von Rezeptoren und Transportern in-vivo und erlaubt dadurch die Untersuchung von z.B. neurologischen, psychiatrischen und onkologischen Erkrankungen auf molekularem Level.
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