Results 241 to 250 of about 59,711 (283)

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

Single-Domain Antibody Probe with Low Renal Uptake for Claudin 18.2-Targeted PET Imaging of Gastric Cancer: Preclinical and Pilot Clinical Evaluations. [PDF]

J Nucl Med
Zheng M, Ma H, Xu T, Mu H, Liu Q, Zhang K, Bian Y, Zhang H, Li W, Zhang B, Shan Y, Peng X, Qin S, Wang Y, Miao L.   +14 more
europepmc   +1 more source

Chelator‐Free Radiometal Labeling Inside Engineered Affibodies

Angewandte Chemie, EarlyView.
Affibodies are compact and robust three‑helix binders used in imaging and therapy. Engineering a triple‑cysteine motif into their core enables chelator‑free binding of important radiometals, like Bi(III), Pb(II), In(III), and Ga(III) with rapid uptake and exceptional stability.
Lani J. Davies, Upamali Somathilake, Santhanalaxmi Kumaresan, Frank Bruchertseifer, Alfred Morgenstern, Sarah Spreckelmeyer, Christoph Nitsche   +6 more
wiley   +1 more source

Positron emission tomography imaging of T-cell activity in cardiovascular disease and its emerging role in imaging adaptive immunity. [PDF]

Am J Nucl Med Mol Imaging
Uddin AS, Bulusu S, Oderinde OM, Zheng QH.   +3 more
europepmc   +1 more source

Biomarkers in preclinical and early Alzheimer's disease in China: a scoping review. [PDF]

J Prev Alzheimers Dis
Peng G, Yang Y, Wang Y, Chandekar SA, Yu J.   +4 more
europepmc   +1 more source

Molecular PET and immuno-PET in gastric cancer immunotherapy: current evidence, clinical utilities, and translational barriers. [PDF]

Front Immunol
Hu Q, Sun Y.
europepmc   +1 more source

Vulnerability of anterior medial temporal lobe subregions to early tau-related neurodegeneration in Alzheimer's disease: Converging evidence from tau-PET and plasma p-tau217. [PDF]

Alzheimers Dement
Mundada NS, Sadeghpour N, McGrew E, Tucker HL, Nasrallah IM, Das SR, Wolk DA, Yushkevich PA, Brown CA, Wisse LEM.   +9 more
europepmc   +1 more source

Plasma p-tau217, p-tau181, and Aβ42 predict amyloid PET positivity in cognitively unimpaired adults. [PDF]

Alzheimers Res Ther
Bao R, Shi W, Bao H, Zhang T, Li X, Ding W, A4 and LEARN Study; The Health and Aging Brain Study (HABS-HD) Study Team.   +6 more
europepmc   +1 more source