Results 221 to 230 of about 55,685 (249)
Some of the next articles are maybe not open access.
Current Trends in Preclinical PET System Design
PET Clinics, 2007PET is used in laboratory small-animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease, and neurologic disorders in living small-animal models of disease. The current and next generation of PET molecular imaging probes, assays, and imaging systems still have substantial room to improve ...
Levin CS, Zaidi H
openaire +3 more sources
Preclinical Studies of SPECT and PET Tracers for NET
PET Clinics, 2014Radiolabeled somatostatin analogues are routinely used for the detection of neuroendocrine tumors (NETs), exploiting the expression of somatostatin-receptor subtypes on the cell membrane. Because of the heterogeneity of the origin of these tumors, the performance of radiolabeled somatostatin analogues in certain types of NETs is limited due to the low ...
Brom, M. +6 more
openaire +3 more sources
Evaluation of the spline reconstruction technique for preclinical PET imaging
Computer Methods and Programs in Biomedicine, 2022The Spline Reconstruction Technique (SRT) is a fast algorithm based on a novel numerical implementation of an analytic representation of the inverse Radon transform. The purpose of this study is to provide a comparison between SRT, Filtered Back-Projection (FBP), Ordered Subset Expectation Maximization 2D (2D-OSEM), and the Tera-Tomo 3D algorithm ...
Alexandros Vrachliotis +7 more
openaire +2 more sources
Detection of preclinical Parkinson's disease with PET
Neurology, 1991Putamen 18F-dopa uptake of patients with Parkinson's disease (PD) is reduced by at least 35% at onset of symptoms; therefore, positron-emission tomography (PET) can be used to detect preclinical disease in clinically unaffected twins and relatives of patients with PD. Three out of 6 monozygotic and 2 out of 3 dizygotic unaffected PD co-twins have shown
openaire +3 more sources
Preclinical PET and SPECT for Radionanomedicine
2018Quantitative evaluation of in vivo biodistribution is a prerequisite for the development of new targeted theranostic probes in nanomedicine. Here in this chapter the principles of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) were explained. These two modalities are now popularly used for small animal studies
Hyung-Jun Im, Gi Jeong Cheon
openaire +1 more source
Preclinical PET imaging study of lung cancer with 64CuCl2
Annals of Nuclear Medicine, 2020Human copper transporter 1 (CTR1) has been proven to be overexpressed in many types of cancer cells, and copper (II)-64 chloride (64CuCl2) has been used as an effective tracer for positron emission tomography (PET) imaging in tumor-bearing animal models.
Qiang Wang +4 more
openaire +2 more sources
Dual-Modality Preclinical SPECT/PET Instrumentation
2014Present multimodality imaging strategies are mostly based on the combination of complementary imaging technique such as PET/CT and SPECT/CT where functional and morphological information on the same subject can be derived and combined. On the shadow of the successful application of combined PET/CT scanners in the clinical environment, multimodality ...
DEL GUERRA, ALBERTO, BELCARI, NICOLA
openaire +2 more sources
Preclinical Molecular Imaging Using PET and MRI
2012Molecular imaging fundamentally changes the way we look at cancer. Imaging paradigms are now shifting away from classical morphological measures towards the assessment of functional, metabolic, cellular, and molecular information in vivo. Interdisciplinary driven developments of imaging methodology and probe molecules utilizing animal models of human ...
Gunter, Wolf, Nasreddin, Abolmaali
openaire +2 more sources
Pharmacological Prerequisites for PET Ligands and Practical Issues in Preclinical PET Research
2006The development of PET radiopharmaceuticals for the non-invasive imaging of cancerous lesions, brain receptors, transporters and enzymes started more than 25 years ago. But till today no established algorithms exist to predict the success of a PET radiopharmaceutical.
Ametamey SM, Honer M
openaire +3 more sources