Results 201 to 210 of about 55,685 (249)

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Engineering CAR‐Macrophages With Advanced Delivery Systems for Tissue Repair

Advanced Science, EarlyView.
This review highlights how engineered macrophages equipped with chimeric antigen receptors (CAR) guide tissue repair by recognizing disease‐related targets, clearing harmful cells, and reshaping local immune environments. It summarizes macrophage biology, CAR design, delivery platforms, and functionalization strategies, and discusses emerging ...
Yixin Zhang, Jintian Yu, Liang Yuan, Ziliang Fu, Yiming Yao, Lingna Chen, Shixiong Chen, Aikemu Ainiwaer, Xiaolin Cui   +8 more
wiley   +1 more source

Clinico-biological trajectories stratified by combined tau biomarkers in preclinical Alzheimer's disease. [PDF]

Alzheimers Res Ther
Labrador-Espinosa MA, Franzmeier N, Karagianni S, Moscoso A, Schöll M.   +4 more
europepmc   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Impact on PET spatial resolution through positron range confinement in a high magnetic field across tissue-equivalent materials. [PDF]

Phys Med Biol
Lopez-Berenguer F, Gonzalez-Montoro A, Freire M, Berr SS, Williams MB, González AJ.   +5 more
europepmc   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

A tissue-informed deep learning-based method for positron range correction in preclinical [Formula: see text]Ga PET imaging. [PDF]

EJNMMI Phys
Encina-Baranda N, Paneque-Yunta RJ, Lopez-Rodriguez J, Pratt EC, Nguyen TN, Grimm J, Lopez-Montes A, Herraiz JL.   +7 more
europepmc   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Single-Domain Antibody Probe with Low Renal Uptake for Claudin 18.2-Targeted PET Imaging of Gastric Cancer: Preclinical and Pilot Clinical Evaluations. [PDF]

J Nucl Med
Zheng M, Ma H, Xu T, Mu H, Liu Q, Zhang K, Bian Y, Zhang H, Li W, Zhang B, Shan Y, Peng X, Qin S, Wang Y, Miao L.   +14 more
europepmc   +1 more source

First-in-human quantitative [¹⁵O]H₂O PET imaging of tumour blood flow at rest and during exercise in lymphoma patients. [PDF]

Acta Oncol
Perros M, Koivula T, Lempiäinen S, Tolvanen T, Kirjavainen A, Nummijärvi L, Sundberg CJ, Rundqvist H, Minn H, Kalliokoski K, Heinonen IHA.   +10 more
europepmc   +1 more source