Results 1 to 10 of about 777,237 (284)

Preclinical models for obesity research [PDF]

Disease Models & Mechanisms, 2016
Acknowledgements The authors are funded by the Scottish Government, Rural and Environment Science and Analytical Services Division, Strategic Research Programme, ‘Food, Health and Wellbeing’ Theme. P.B.
Barrett, Perry, Mercer, Julian G, Morgan, Peter J   +2 more
core   +7 more sources

Biochemical changes associated with non-alcoholic fatty liver disease in response to berberine treatment: a systematic review and meta-analysis of clinical and preclinical research [PDF]

Frontiers in Pharmacology
BackgroundNon-alcoholic fatty liver disease (NAFLD) represents a global health challenge. Berberine, an isoquinoline alkaloid traditionally used for metabolic disorders, has garnered attention for its potential therapeutic interventions.ObjectiveTo ...
Wenyu Zhu, Lele Yang, Yufan Dai, Hanyang Wang, Jiaxuan Zhou, Lina Xia, Tao Shen   +6 more
doaj   +2 more sources

The Chicken Embryo: An Old but Promising Model for In Vivo Preclinical Research [PDF]

Biomedicines
The chicken embryo has emerged as a valuable model for preclinical studies due to its unique combination of accessibility, affordability, and relevance to human biology.
Annachiara Sarnella, Ylenia Ferrara, Cristina Terlizzi, Sandra Albanese, Serena Monti, Luca Licenziato, Marcello Mancini   +6 more
doaj   +2 more sources

Sex matters in preclinical research

Disease Models & Mechanisms
ABSTRACT International Women's Day 2024 has a theme of inclusion. As publishers of preclinical research, we aim to show how inclusion of females in research advances scientific rigor and improves treatment reliability. Sexual reproduction is key to all life across the plant and animal kingdoms.
Justice MJ.
openaire   +4 more sources

Preclinical research models for endometrial cancer: development and selection of animal models [PDF]

Frontiers in Oncology
Endometrial cancer (EC) is the most common gynecological malignancy in developed countries, with rising incidence in recent years. Experimental animal models are crucial for studying the pathogenesis, advancing diagnostic methods, and developing new ...
Yang Xue, Wei Shi, Bing Lun, Meilin Kan, Mengling Jia, Yuelin Wu, Li Yang, Li Yang   +7 more
doaj   +2 more sources

Modulation of tumor immune microenvironment by TAS-115, a multi-receptor tyrosine kinase inhibitor, promotes antitumor immunity and contributes anti-PD-1 antibody therapy

Scientific Reports, 2023
TAS-115 is an oral multi-receptor tyrosine kinase inhibitor that strongly inhibits kinases implicated in antitumor immunity, such as colony stimulating factor 1 receptor and vascular endothelial growth factor receptor.
Toshihiro Shibutani, Risa Goto, Isao Miyazaki, Akihiro Hashimoto, Takamasa Suzuki, Keiji Ishida, Tomonori Haruma, Toshihiro Osada, Takafumi Harada, Hidenori Fujita, Shuichi Ohkubo   +10 more
doaj   +1 more source

TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress

Communications Biology, 2022
A small-molecule protein-protein interaction inhibitor of ribonucleotide reductase subunit, TAS1553, is shown to inhibit growth of both hematological and solid cancer xenograft tumors following oral administration in mice.
Hiroyuki Ueno, Takuya Hoshino, Wakako Yano, Sayaka Tsukioka, Takamasa Suzuki, Shoki Hara, Yoshio Ogino, Khoon Tee Chong, Tatsuya Suzuki, Shingo Tsuji, Hikaru Itadani, Ikuo Yamamiya, Yoshihiro Otsu, Satoshi Ito, Toshiya Yonekura, Miki Terasaka, Nozomu Tanaka, Seiji Miyahara   +17 more
doaj   +1 more source

Preclinical Models: Boosting Synergies for Improved Translation [PDF]

, 2020
The field of preclinical models is a very vast arena, in which finding connections among groups acting in apparently very distant research areas can sometimes prove challenging [...
Attanasio C., Sangiovanni M.
core   +1 more source

Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms. [PDF]

, 2020
Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones.
Biglia, Nicoletta, Birkhaeuser, Martin, Brincat, Mark, Celis-Gonzales, Cuauhtémoc, Depypere, Herman, Egarter, Christian, Fait, Tomas, Genazzani, Andrea, Goldstein, Steven, Mueck, Alfred, Palacios, Santiago, Panay, Nick, Ruan, Xiangyan, Simoncini, Tommaso, Skouby, Sven O   +14 more
core   +4 more sources

Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]

, 2012
Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Members of the MCAO-SOP Group, Ulrich Dirnagl   +1 more
core   +2 more sources