Results 11 to 20 of about 777,237 (284)
Journal of Lipid Research, 1994 Oxidative modifications of lipoproteins appear to contribute to their atherogenicity. Very low and low density lipoproteins (VLDL and LDL) are protected against these modifications by antioxidants that can be incorporated in vivo or in vitro into the ...
C Hallberg +8 more
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Update and New Insights on Future Cancer Drug Candidates From Plant-Based Alkaloids
Frontiers in Pharmacology, 2021 Cancer is a complex multifactorial disease that results from alterations in many physiological and biochemical functions. Over the last few decades, it has become clear that cancer cells can acquire multidrug resistance to conventional anticancer drugs ...
Mounir Tilaoui +2 more
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Standard operating procedures (SOP) in experimental stroke research: SOP for middle cerebral artery occlusion in the mouse [PDF]
, 2009 Recently, systematic reviews have found quantitative evidence that low study quality may have introduced a bias into preclinical stroke research. Monitoring, auditing, and standard operating procedures (SOPs) are already key elements of quality control ...
Members of the MCAO-SOP Group +1 more
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Preclinical Stroke Research [PDF]
Stroke, 2013 The Stroke Progress Review Group, commissioned by National Institute of Neurological Disorders and Stroke to review the status of stroke research in 2011, addressed a variety of clinical and preclinical areas, including progress and unmet needs in preclinical investigation.1 Identified among the latter were the need to develop better molecular ...
openaire +2 more sources
Ximenia americana L.: Chemical Characterization and Gastroprotective Effect
Analytica, 2023 Ximenia americana L., popularly known in Brazil as “ameixa do-mato, ameixa-brava, and ameixa-do-sertão,” is widely used in folk medicine to treat several intestinal disorders.
Renata Torres Pessoa +14 more
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Technological advances in preclinical meta-research [PDF]
BMJ Open Science, 2021 Metaresearch is a scientific field involving the study of research itself. It has been applied to clinical trials since the 1980s,1 but has only become an emerging discipline over the last decade in the preclinical field. The primary tool of metaresearch is the systematic review, which uses predefined methods to provide a transparent and comprehensive ...
Bannach-Brown, A +5 more
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Optimizing dual energy cone beam CT protocols for preclinical imaging and radiation research [PDF]
, 2017 Objective: The aim of this work was to investigate whether quantitative dual-energy CT (DECT) imaging is feasible for small animal irradiators with an integrated cone-beam CT (CBCT) system.
Almeida, Isabel P +7 more
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Xenotransplantation: Current Status in Preclinical Research [PDF]
Frontiers in Immunology, 2020 The increasing life expectancy of humans has led to a growing numbers of patients with chronic diseases and end-stage organ failure. Transplantation is an effective approach for the treatment of end-stage organ failure; however, the imbalance between organ supply and the demand for human organs is a bottleneck for clinical transplantation.
Tianyu Lu +11 more
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Is preclinical research in cancer biology reproducible enough?
eLife, 2021 The Reproducibility Project: Cancer Biology (RPCB) was established to provide evidence about reproducibility in basic and preclinical cancer research, and to identify the factors that influence reproducibility more generally.
Patrick Bodilly Kane, Jonathan Kimmelman
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Virology Journal, 2018 Background A new promising therapeutic approach has emerged for patients chronically infected by the hepatitis B virus (HBV) with the development of a non-replicative adenovirus vector vaccine candidate (Ad-HBV).
Xuefeng Zhang +4 more
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