Results 21 to 30 of about 777,237 (284)

Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer\u27s disease [PDF]

, 2019
Interest in understanding the roles of white matter (WM) inflammation and damage in the pathophysiology of Alzheimer disease (AD) has been growing significantly in recent years.
Ances, Beau M, Benzinger, Tammie L.S., Blazey, Tyler, Cairns, Nigel J, Chen, Charlie, Cruchaga, Carlos, Fagan, Anne M, Gordon, Brian A, Liu, Jingxia, Morris, John C, Shimony, Joshua S, Su, Yi, Sutphen, Courtney L, Wang, Qing, Wang, Yong   +14 more
core   +2 more sources

Correction to: Immunogenicity of adenovirus-vector vaccine targeting hepatitis B virus: non-clinical safety assessment in non-human primates

Virology Journal, 2018
Ad-HBV is a product (T101) aiming to treat chronic HBV firstly developed by Transgene S.A., France then by Transgene Tasly (Tianjin) Biopharmaceutical Co., Ltd., Tianjin, China in China.
Xuefeng Zhang, Jing Wang, Jing Lu, Rongrong Li, Shuli Zhao   +4 more
doaj   +1 more source

Treatment of glioblastoma with current oHSV variants reveals differences in efficacy and immune cell recruitment

Molecular Therapy: Oncolytics, 2021
Oncolytic herpes simplex viruses (oHSVs) have demonstrated efficient lytic replication in human glioblastoma tumors using immunodeficient mouse models, but early-phase clinical trials have reported few complete responses.
Joseph W. Jackson, Bonnie L. Hall, Marco Marzulli, Vrusha K. Shah, Lisa Bailey, E. Antonio Chiocca, William F. Goins, Gary Kohanbash, Justus B. Cohen, Joseph C. Glorioso   +9 more
doaj   +1 more source

The Brain-Gut-Microbiome Axis. [PDF]

, 2018
Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis. Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and ...
Kalani, Amir, Martin, Clair R, Mayer, Emeran A, Osadchiy, Vadim   +3 more
core   +2 more sources

Designing an In Vivo Preclinical Research Study

Surgeries, 2023
During the preclinical research process, multiple factors can be difficult to implement without the careful consideration and planning of each step. As research has become more advanced with the use of increasingly complex technology, animal models have ...
Angel Moctezuma-Ramirez, David Dworaczyk, Julia Whitehorn, Ke Li, Cristiano de Oliveira Cardoso, Abdelmotagaly Elgalad   +5 more
doaj   +1 more source

Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials [PDF]

, 2015
Heart valve tissue-guided regeneration aims to offer a functional and viable alternative to current prosthetic replacements. Not requiring previous cell seeding and conditioning in bioreactors, such exceptional tissue engineering approach is a very ...
Gerosa, Gino, Iop, Laura
core   +4 more sources

Preclinical Pain Research [PDF]

Anesthesiology, 2016
Abstract Regrettably, the list of unique analgesic tools has expanded very slowly during the past few decades. Many very promising drugs have failed once tested in clinical populations, and the associated costs of these translational failures have been extremely high.
openaire   +2 more sources

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies [PDF]

, 2019
In cancer research, it remains challenging to functionally validate putative novel oncogenic drivers and to establish relevant preclinical models for evaluation of novel therapeutic strategies.
Berx, Geert, D'Hont, Jinke, Demoen, Lisa, Goossens, Steven, Haenebalcke, Lieven, Haigh, Jody J., Hochepied, Tino, Lammens, Tim, Lemeire, Kelly, Lintermans, Béatrice, Matthijssens, Filip, Pedro Pinto De Almeida, André, Pieters, Tim, Reunes, Lindy, T'Sas, Sara, Van Vlierberghe, Pieter, Vanrockeghem, Frédérique   +16 more
core   +2 more sources

Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells.

Journal of Lipid Research, 1996
Within the cholesterol biosynthesis cascade, the enzyme 2,3-oxidosqualene cyclase [EC 5.4.99.7] is of special interest due to its dual function: cyclization of 2,3-monoepoxysqualene to lanosterol and 2,3;22,23-diepoxysqualene to oxylanosterol.
M Mark, P Muller, R Maier, B Eisele
doaj   +1 more source

Metabolomics in toxicology and preclinical research

ALTEX, 2013
Metabolomics, the comprehensive analysis of metabolites in a biological system, provides detailed information about the biochemical/physiological status of a biological system, and about the changes caused by chemicals. Metabolomics analysis is used in many fields, ranging from the analysis of the physiological status of genetically modified organisms ...
Ramirez, Tzutzuy, Daneshian, Mardas, Kamp, Hennicke, Bois, Frédéric Y., Clench, Malcom R., Coen, Muireann, Donley, Beth, Fischer, Steven M., Ekman, Drew R., Fabian, Eric, Guillou, Claude, Heuer, Joachim, Hogberg, Helena T., Jungnickel, Harald, Keun, Hector C., Krennrich, Gerhard, Krupp, Eckart, Luch, Andreas, Noor, Fozia, Peter, Erik, Riefke, Bjoern, Seymour, Mark, Skinner, Nigel, Smirnova, Lena, Verheij, Elwin, Wagner, Silvia, Hartung, Thomas, van Ravenzwaay, Bennard, Leist, Marcel   +28 more
openaire   +6 more sources