Results 1 to 10 of about 808,538 (334)

Improving preclinical studies through replications

eLife, 2021
The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans.
Natascha Ingrid Drude, Lorena Martinez Gamboa, Meggie Danziger, Ulrich Dirnagl, Ulf Toelch   +4 more
doaj   +3 more sources

Pharmaceutical Toxicology is the Most Important Component of Preclinical Studies

Регуляторные исследования и экспертиза лекарственных средств, 2023
The first principle for ensuring patient safety is to do no harm (primum non nocere). It clearly justifies why the legislative requirements for the safety of medicinal products should be strict and meticulous. The aim of preclinical safety evaluation    
A. D. Durnev
doaj   +1 more source

The antimicrobial and antibiofilm properties of allicin against Candida albicans and Staphylococcus aureus – A therapeutic potential for denture stomatitis

Saudi Dental Journal, 2021
The objective of this study is to determine the therapeutic efficacy of allicin against Candida albicans (C. albicans) and Staphylococcus aureus (S. aureus), the common etiological agents for denture stomatitis (DS). The minimum inhibitory concentration (
Mukarramah Zainal, Nurhayati Mohamad Zain, Indah Mohd Amin, Vivi Noryati Ahmad   +3 more
doaj   +1 more source

High molecular pyrogens present in plant extracts interfere with examinations of their immunomodulatory properties in vitro

Scientific Reports, 2021
The widely accepted strategy to justify the use of medicinal plant extracts in diseases with inflammatory background is their examination on in vitro models using immune cells.
Aleksandra Kruk, Jakub P. Piwowarski, Karolina A. Pawłowska, Dominik Popowski, Sebastian Granica   +4 more
doaj   +1 more source

Purified and specific cytoplasmic pollen extract: a non-hormonal alternative for the treatment of menopausal symptoms. [PDF]

, 2020
Research into non-hormonal, alternative therapies is necessary for women for whom menopausal hormone therapy is contraindicated or for women who do not wish to take hormones.
Biglia, Nicoletta, Birkhaeuser, Martin, Brincat, Mark, Celis-Gonzales, Cuauhtémoc, Depypere, Herman, Egarter, Christian, Fait, Tomas, Genazzani, Andrea, Goldstein, Steven, Mueck, Alfred, Palacios, Santiago, Panay, Nick, Ruan, Xiangyan, Simoncini, Tommaso, Skouby, Sven O   +14 more
core   +4 more sources

Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence

Antioxidants, 2021
Obesity represents one of the most important challenges in the contemporary world that must be overcome. Different pathological consequences of these physical conditions have been studied for more than 30 years.
Proshanta Roy, Daniele Tomassoni, Enea Traini, Ilenia Martinelli, Maria Vittoria Micioni Di Bonaventura, Carlo Cifani, Francesco Amenta, Seyed Khosrow Tayebati   +7 more
doaj   +1 more source

Boosting the Intra-Articular Efficacy of Low Dose Corticosteroid through a Biopolymeric Matrix: An In Vivo Model of Osteoarthritis

Cells, 2020
The purpose of this study was to verify the efficacy of a single intra-articular (i.a.) injection of a hyaluronic acid-chitlac (HY-CTL) enriched with two low dosages of triamcinolone acetonide (TA, 2.0 mg/mL and 4.5 mg/mL), in comparison with HY-CTL ...
Matilde Tschon, Francesca Salamanna, Lucia Martini, Gianluca Giavaresi, Luca Lorenzini, Laura Calzà, Milena Fini   +6 more
doaj   +1 more source

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]

, 2012
Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
Brentjens, Renier J., Castro Alves, Catarina, Ehrhardt, Harald, Farkasova, Katarina, Groiss, Volker, Horstmann, Martin, Jeremias, Irmela, Ogris, Manfred, Quintanilla-Martinez, Leticia, Schneider, Katja, Terziyska, Nadia, Wagner, Ernst, zur Stadt, Udo   +12 more
core   +11 more sources

Pharmacokinetics of Free Oxytetracycline and Oxytetracycline Loaded Cockle Shell Calcium Carbonate-Based Nanoparticle in BALB/c Mice

Frontiers in Veterinary Science, 2020
The development and utilization of nano-antibiotics is currently gaining attention as a possible solution to antibiotic resistance. The aim of this study was therefore to determine the pharmacokinetics of free oxytetracycline (OTC) and oxytetracycline ...
Sherifat Banke Idris, Sherifat Banke Idris, Arifah Abdul Kadir, Jesse F. F. Abdullah, Siti-Zubaidah Ramanoon, Muhammad Abdul Basit, Muhammad Abdul Basit, Md Zuki Z. A. Abubakar   +7 more
doaj   +1 more source

Preparation, characterization and in vitro cytotoxicity evaluation of free and liposome-encapsulated tylosin

OpenNano, 2022
Liposomes are the most attractive and well-known nanoparticles due to their high biocompatibility and biodegradability features which make them display less toxic effects for employing in vivo.
Mohammad Ehsan Saddiqi, Arifah Abdul Kadir, Faez Firdaus Jesse Abdullah, Md Zuki Abu Bakar Zakaria, Idris Sherifat Banke   +4 more
doaj   +1 more source