Results 1 to 10 of about 762,558 (336)
Improving preclinical studies through replications
eLife, 2021 The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans.
Natascha Ingrid Drude +4 more
doaj +3 more sources
Oncolysis by paramyxoviruses: preclinical and clinical studies
Molecular Therapy: Oncolytics, 2015 Preclinical studies demonstrate that a broad spectrum of human malignant cells can be killed by oncolytic paramyxoviruses, which include cells of ecto-, endo-, and mesodermal origin.
Olga V Matveeva +5 more
doaj +4 more sources
Pharmaceutical Toxicology is the Most Important Component of Preclinical Studies
Регуляторные исследования и экспертиза лекарственных средств, 2023 The first principle for ensuring patient safety is to do no harm (primum non nocere). It clearly justifies why the legislative requirements for the safety of medicinal products should be strict and meticulous. The aim of preclinical safety evaluation
A. D. Durnev
doaj +1 more source
Saudi Dental Journal, 2021 The objective of this study is to determine the therapeutic efficacy of allicin against Candida albicans (C. albicans) and Staphylococcus aureus (S. aureus), the common etiological agents for denture stomatitis (DS). The minimum inhibitory concentration (
Mukarramah Zainal +3 more
doaj +1 more source
Scientific Reports, 2021 The widely accepted strategy to justify the use of medicinal plant extracts in diseases with inflammatory background is their examination on in vitro models using immune cells.
Aleksandra Kruk +4 more
doaj +1 more source
Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence
Antioxidants, 2021 Obesity represents one of the most important challenges in the contemporary world that must be overcome. Different pathological consequences of these physical conditions have been studied for more than 30 years.
Proshanta Roy +7 more
doaj +1 more source
Cells, 2020 The purpose of this study was to verify the efficacy of a single intra-articular (i.a.) injection of a hyaluronic acid-chitlac (HY-CTL) enriched with two low dosages of triamcinolone acetonide (TA, 2.0 mg/mL and 4.5 mg/mL), in comparison with HY-CTL ...
Matilde Tschon +6 more
doaj +1 more source
Frontiers in Veterinary Science, 2020 The development and utilization of nano-antibiotics is currently gaining attention as a possible solution to antibiotic resistance. The aim of this study was therefore to determine the pharmacokinetics of free oxytetracycline (OTC) and oxytetracycline ...
Sherifat Banke Idris +7 more
doaj +1 more source
OpenNano, 2022 Liposomes are the most attractive and well-known nanoparticles due to their high biocompatibility and biodegradability features which make them display less toxic effects for employing in vivo.
Mohammad Ehsan Saddiqi +4 more
doaj +1 more source
Experimental study of the pharmacological activity of new azaheterocycles derivatives: A literature review [PDF]
Ķazaķstannyṇ Klinikalyķ Medicinasy, 2022 Diseases associated with the pathology of the cardiovascular system are one of the key causes of death all over the world. In particular, arrhythmia may entail the most severe complications, including unexpected death.
Malika Khaiitova +4 more
doaj +1 more source