Results 31 to 40 of about 803,041 (283)

Dual role of complement in neuronal repair

Frontiers in Immunology
The complement system, long regarded as an arm of innate immunity, is now recognized as an important modulator of nervous system pathophysiology. Following acute injury or in chronic neurodegenerative diseases, promoting neuronal survival and axon ...
Agnieszka Lukomska, Peter Ciesielski, Mariusz Z. Ratajczak, Mariusz Z. Ratajczak, Magdalena Kucia   +4 more
doaj   +1 more source

Statistical considerations for preclinical studies [PDF]

Experimental Neurology, 2015
Research studies must always have proper planning, conduct, analysis and reporting in order to preserve scientific integrity. Preclinical studies, the first stage of the drug development process, are no exception to this rule. The decision to advance to clinical trials in humans relies on the results of these studies.
Inmaculada B, Aban, Brandon, George
openaire   +2 more sources

Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]

, 2006
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y, Baghai TC, Baker ER, Barrett-Connor E, Bicikova M, Bitran D, Bloch M, Brambilla F, Brambilla F, Brambilla F, Cornelius Schüle, Crawley JN, Dalton K, Daniela Eser, Dennerstein L, Dong E, Elena Romeo, Eser D, Evans RM, Fabian TJ, Freeman E, Freeman EW, Friess E, George MS, Goodyer IM, Guidotti A, Heydari B, Heydary B, Kita A, Koszycki D, Lawrie TA, Maayan R, Magill PJ, Majewska MD, Majewska MD, Majewska MD, Matsumoto K, Meieran SE, Melchior CL, Melchior CL, Mensah-Nyagan AG, Mienville JM, Monnet FP, Padberg F, Papadopoulos V, Paul SM, Purdy RH, Rainer Rupprecht, Reddy DS, Reddy DS, Reddy DS, Rodgers RJ, Romeo E, Rupprecht R, Rupprecht R, Schmidt PJ, Schule C, Schule C, Semeniuk T, Serra M, Serra M, Strohle A, Strohle A, Strohle A, Strous RD, Takebayashi M, Thomas C. Baghai, Tollefson GD, Trauger JW, Urani A, Uzunov DP, Uzunova V, Uzunova V, Uzunova V, Vanselow W, Wieland S, Wolkowitz OM, Wolkowitz OM, Wu FS, Zwanzger P   +79 more
core   +1 more source

Commensal Microbiota Effects on Craniofacial Skeletal Growth and Morphology

JBMR Plus, 2023
Microbes colonize anatomical sites in health to form commensal microbial communities (e.g., commensal gut microbiota, commensal skin microbiota, commensal oral microbiota).
Joy E. Gerasco, Jessica D. Hathaway‐Schrader, Nicole A. Poulides, Matthew D. Carson, Naoto Okhura, Caroline Westwater, Nan E. Hatch, Chad M. Novince   +7 more
doaj   +1 more source

18F-FES radiation dosimetry preliminary estimates for preclinical studies based on voxelized phantom

Brazilian Journal of Radiation Sciences, 2022
Small animals, such as mice, are used in radiopharmaceutical biodistribution studies and innumerous others preclinical investigations involving ionizing radiation.
Andréa Vidal Ferreira, Ana Carolina Araujo Bispo, Christiane Silva Leite, Juliana Batista da Silva, Marcelo Mamede, Rodrigo Modesto Gadelha Gontijo, Bruno Melo Mendes   +6 more
doaj   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Pyronaridine tetraphosphate is an efficacious antiviral and anti-inflammatory active against multiple highly pathogenic coronaviruses

mBio, 2023
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), continues to be one of the largest dangers to human health around the world.
Jeremy Ardanuy, Robert Johnson, Carly Dillen, Louis Taylor, Holly Hammond, Stuart Weston, Matthew Frieman   +6 more
doaj   +1 more source

Efficacy and Tolerability of Topotecan/Cyclophosphamide/Dinutuximab in Relapsed and Refractory High‐Risk Neuroblastoma: A Multi‐Institutional Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Chemoimmunotherapy with irinotecan, temozolomide, and dinutuximab (I/T/DIN) has emerged as first‐line therapy for relapsed/refractory (r/r) high‐risk neuroblastoma (HRNB) in North America. Topotecan and cyclophosphamide (T/C) are often used in combination with dinutuximab in the setting of lack of response, progression, or incomplete ...
Benjamin J. Lerman, Madeleine King, Rajen Mody, Sara‐Jane Onyeama, Araz Marachelian, Thomas Cash, Sara M. Federico, Meaghan Granger, Ami V. Desai, Suzanne Shusterman, Jennifer H. Foster, Elizabeth Sokol, Chelsee Greer, Keri Streby, Holly J. Meany, Kieuhoa T. Vo, Margaret E. Macy, Rochelle Bagatell   +17 more
wiley   +1 more source

scRNA-seq revealed transcriptional signatures of human umbilical cord primitive stem cells and their germ lineage origin regulated by imprinted genes

Scientific Reports
A population of CD133+lin-CD45- and CD34+lin-CD45- very small embryonic-like stem cells (VSELs) has been identified in postnatal human tissues, including bone marrow (BM), mobilized peripheral blood (mPB) and umbilical cord blood (UCB). Under appropriate
Justyna Jarczak, Kamila Bujko, Mariusz Z. Ratajczak, Magdalena Kucia   +3 more
doaj   +1 more source

Combination of a high-carbohydrate diet and streptozotoc in for modeling type 2 diabetes in Wistar rats

Фармакокинетика и Фармакодинамика, 2023
Relevance. To conduct a preclinical evaluation of the effectiveness of antidiabetic drugs, models simulating the pathogenesis and main manifestations of diabetes mellitus (DM) in humans are needed.
S. V. Ivanov, R. U. Ostrovskaya
doaj   +1 more source