Results 111 to 120 of about 22,776 (283)

Multipreconditioned GMRES for simulating stochastic automata networks

open access: yesOpen Mathematics, 2018
Stochastic Automata Networks (SANs) have a large amount of applications in modelling queueing systems and communication systems. To find the steady state probability distribution of the SANs, it often needs to solve linear systems which involve their ...
Wen Chun   +5 more
doaj   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

open access: yesAdvanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan   +11 more
wiley   +1 more source

Biolipid Film‐Fused Electrochemiluminescence for Multipurpose In Situ Bioassays

open access: yesAdvanced Science, EarlyView.
An ECL‐emissive, membrane‐interactive scaffold was fabricated, and facilely fused with natural and non‐native phospholipids into multifactorial mimicries of cytomembranes and vesicles for in vitro representative membrane‐process probing. Such a biointerface‐based, state‐sensitive ECL paradigm not only pinpointed proximal phenomena, including channeling
Jialiang Chen   +9 more
wiley   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

open access: yesAdvanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong   +8 more
wiley   +1 more source

Injectable Porous Microspheres Loaded With Biomimetic Preconditioned Bone Marrow Mesenchymal Stem Cell‐Derived Exosomes for Vascularized Bone Regeneration

open access: yesAdvanced Science, EarlyView.
Schematic illustration of injectable PDA‐modified GelMA microspheres loaded with BioPre‐Exos for vascularized bone regeneration. ABSTRACT Critical‐sized bone defects remain a highly challenging clinical problem due to insufficient intrinsic self‐healing capacity.
Lijun Li   +9 more
wiley   +1 more source

Ambipolar Organic–Inorganic Heterostructure Transistor Array for Integrated Visual Information Processing

open access: yesAdvanced Science, EarlyView.
We present an organic–inorganic heterostructure transistor array for neuromorphic computing, achieving 95.6% MNIST accuracy and 1.2 fJ per operation, with dynamic spatiotemporal encoding and precise vehicle direction detection under combined optical and electrical stimulation.
Wen‐Min Zhong   +13 more
wiley   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs   +4 more
wiley   +1 more source

Numerical Simulation of One-Phase Flow to Multi-Stage Hydraulically Fractured Horizontal Well [PDF]

open access: yesУчёные записки Казанского университета: Серия Физико-математические науки, 2016
This paper presents a method of numerical simulation of one-phase flow near multi-stage fractured horizontal well in oil reservoir. Differential models for flows within reservoir and within fractures are formulated separately on the basis of Darcy's law.
M.R. Khamidullin
doaj  

Physics‐Based Compact Modeling of Advanced 3D Nanoscale Vertical NAND Flash Memory

open access: yesAdvanced Electronic Materials, EarlyView.
For advanced 3D NAND flash memory, a unified compact model for SPICE is proposed that spans from the intrinsic unit cell to the full string and captures the electrostatic coupling with adjacent inhibit strings. It can successfully predict read behavior, program/erase dynamics, and interactions between neighboring cells, reflecting array‐level behavior ...
Ilho Myeong, Seonho Shin, Ickhyun Song
wiley   +1 more source

Strain‐Directed Ru Redistribution to Form RuO2/Pt Mosaic Heterointerfaces for Acid‐Stable Water Oxidation

open access: yesAdvanced Energy Materials, EarlyView.
Strain‐driven Ru inward migration creates confined RuO2/Pt mosaic heterointerfaces within a PtNi multiframe. These interfaces enable redox‐asymmetric Pt–Ru coupling that stabilizes Ru4+, suppresses lattice oxygen participation, and promotes highly durable acidic oxygen evolution.
Yeji Park   +13 more
wiley   +1 more source

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