Results 121 to 130 of about 9,971 (304)
A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints
Advanced Science, EarlyView.ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu +3 more
wiley +1 more source
Numerical Simulation of One-Phase Flow to Multi-Stage Hydraulically Fractured Horizontal Well [PDF]
Учёные записки Казанского университета: Серия Физико-математические науки, 2016 This paper presents a method of numerical simulation of one-phase flow near multi-stage fractured horizontal well in oil reservoir. Differential models for flows within reservoir and within fractures are formulated separately on the basis of Darcy's law.
M.R. Khamidullin
doaj
A Proposal for a Dynamically Adapted Inexact Additive
, 2008 Additive Schwarz is a powerful preconditioner used in conjuction with Krylov subspace methods (e.g., GMRES [7]) for the solution of linear systems of equations of the form Au = f, especially those arising from discretizations of differential equations on
Marcus Sarkis +2 more
core
Advanced Science, EarlyView.A flexible, hexagonally packed artificial dielectric providing a wide range of effective permittivities (εr ≈ 30–1400) without lumped elements was developed for clinical and ultra‐high‐field MRI. Combined with modular passive‐dipole arrays, the system enables adaptable RF field shaping through electric‐ and magnetic‐dipole tuning.
Santosh Kumar Maurya +2 more
wiley +1 more source
Parallel Double Sweep Preconditioner for the Optimized Schwarz Algorithm Applied to High Frequency Helmholtz and Maxwell Equations [PDF]
, 2016 peer reviewedObserving that the optimized Schwarz algorithm is equivalent to the solution of a linear system, we design a new preconditioner as an approximate inverse of the iteration operator, in the particular case of a layered decomposi- tion. We show
Vion, Alexandre, Geuzaine, Christophe
core +1 more source
An improved DWT-based preconditioner for dense matrix problems
, 2002 We present a new preconditioning method for a class of dense matrices, based on sparse approximation in a discrete wavelet basis. We rst prove theoretical results that enable us to reduce the cost of an existing waveletbased preconditioner and then ...
Judith M. Ford
core
An optimal Schwarz preconditioner for a class of parallel adaptive finite elements
, 2017 A Schwarz-type preconditioner is formulated for a class of parallel adaptive finite elements where the local meshes cover the whole domain. With this preconditioner, the convergence rate of the conjugate gradient method is shown to depend only on the ...
Loisel, Sébastien +3 more
core +1 more source
Robots and Minimal, Physics‐Informed Features: A Hybrid Framework for Enzyme Catalysis
Advanced Science, EarlyView.Robotic experimentation and physics‐informed machine learning combine to predict enzyme substrate scope. With a handful of interpretable features derived from docking and quantum mechanics calculations, our model rivals descriptor‐heavy AI approaches and extrapolates to unseen substrates and enzyme classes.
Natalia Onishchenko +8 more
wiley +1 more source
Advanced Science, EarlyView.Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen +7 more
wiley +1 more source
An Inexact Balancing Preconditioner for Large-Scale Structural Analysis
, 2008 The balancing domain decomposition (BDD) method is a well-known preconditioner due to its excellent convergence rate. The BDD method includes the Neumann-Neumann preconditioner and a coarse grid correction. Several studies have considered applications of
Ogino, Masao +5 more
core