Results 131 to 140 of about 1,263 (265)

All‐Inside Primary Anterior Cruciate Ligament Reconstruction Using a Combined Polyester Synthetic Graft and Gracilis Tendon Autograft: Modified Technique of a Hybrid 4 × 2 Graft Preparation

open access: yesArthroscopy Techniques, EarlyView.
Abstract Anterior cruciate ligament reconstruction is a frequently performed procedure in arthroscopic surgery, with rising rates paralleling the incidence of anterior cruciate ligament ruptures worldwide. Synthetic grafts, especially hybrid constructs combining artificial devices with autologous tissue, offer biomechanical advantages and potential ...
Ion Bogdan Codorean   +3 more
wiley   +1 more source

From cramming to binge‐watching: Integrating documentary‐based assessment into a pharmacology and toxicology curriculum—a qualitative study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims In the context of pharmacology and toxicology education, there is a growing shift toward programmatic assessment models that prioritize longitudinal learning, reflection and development of higher‐order cognitive skills. As part of this transition, we are exploring alternative and more meaningful forms of assessment. This qualitative study
Narin Akrawi   +2 more
wiley   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg   +7 more
wiley   +1 more source

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa   +5 more
wiley   +1 more source

Optimal Scheme to Achieve Energy Conservation in Induced Dipole Models. [PDF]

open access: yesJ Chem Theory Comput, 2023
Huang Z   +5 more
europepmc   +1 more source

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