Results 81 to 90 of about 46,756 (266)
Advanced Science, EarlyView.The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo +6 more
wiley +1 more source
Mitochondrial preconditioning: a potential neuroprotective strategy
Frontiers in Aging Neuroscience, 2010 Mitochondria have long been known as the powerhouse of the cell. However, these organelles are also pivotal players in neuronal cell death. Mitochondrial dysfunction is a prominent feature of chronic brain disorders, including Alzheimer's and ...
Sónia C Correia +17 more
doaj +1 more source
Advanced Science, EarlyView.Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng +14 more
wiley +1 more source
Frontiers in Physiology, 2016 Purpose: Since non-provocative dive profiles are no guarantor of protection against decompression sickness, novel means including pre-dive preconditioning interventions, are proposed for its prevention.
Costantino Balestra +12 more
doaj +1 more source
Optimal Diagonal Preconditioning
Operations ResearchA New Practical Algorithm Enables Optimal Preconditioning A classic and important question in optimization and numerical methods is how to find diagonal preconditioners to maximally reduce the condition number of any matrix with full rank. Until recently, few practical methods could handle large sparse matrices. In “Optimal Diagonal Preconditioning,”
Zhaonan Qu +4 more
openaire +3 more sources
Advanced Science, EarlyView.A programmable 2048‐element circular ultrasound array combined with a compact acoustic lens produces a thin “sound sheet” over a large field of view, and records echoes with wide angular diversity across the ring aperture. Coherence‐enhanced beamforming converts full‐matrix data into high‐contrast tomographic slices, delivering near‐diffraction‐limited
Qiu‐De Zhang +11 more
wiley +1 more source
Role of MicroRNAs in innate neuroprotection mechanisms due to preconditioning of the brain
Frontiers in Neuroscience, 2015 Insults to the brain that are sub-threshold for damage activate endogenous protective pathways, which can temporarily protect the brain against a subsequent harmful episode.
Eva Maria Jimenez-Mateos
doaj +1 more source
Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis
Advanced Science, EarlyView.This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun +15 more
wiley +1 more source
Advanced Science, EarlyView.This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma +10 more
wiley +1 more source
Fast and accurate surface normal integration on non-rectangular domains
Computational Visual Media, 2017 The integration of surface normals for the purpose of computing the shape of a surface in 3D space is a classic problem in computer vision. However, even nowadays it is still a challenging task to devise a method that is flexible enough to work on non ...
Martin Bähr +4 more
doaj +1 more source