Results 71 to 80 of about 2,150,687 (292)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Training Population Design With the Use of Regional Fusarium Head Blight Nurseries to Predict Independent Breeding Lines for FHB Traits

Frontiers in Plant Science, 2020
Fusarium head blight (FHB) is a devastating disease in cereals around the world. Because it is quantitatively inherited and technically difficult to reproduce, breeding to increase resistance in wheat germplasm is difficult and slow.
Virginia L. Verges, Jeanette Lyerly, Yanhong Dong, David A. Van Sanford   +3 more
doaj   +1 more source

Genomic Selection for Live Weight in the 14th Month in Alpine Merino Sheep Combining GWAS Information

Animals, 2023
Alpine Merino Sheep is a novel breed reared from Australian Merino Sheep as the father and Gansu Alpine Fine-Wool Sheep as the mother, living all year in cold and arid alpine areas with exceptional wool quality and meat performance.
Chenglan Li, Jianye Li, Haifeng Wang, Rui Zhang, Xuejiao An, Chao Yuan, Tingting Guo, Yaojing Yue   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Quantitative genetics theory for genomic selection and efficiency of breeding value prediction in open-pollinated populations

Scientia Agricola, 2016
To date, the quantitative genetics theory for genomic selection has focused mainly on the relationship between marker and additive variances assuming one marker and one quantitative trait locus (QTL).
José Marcelo Soriano Viana, Hans-Peter Piepho, Fabyano Fonseca e Silva   +2 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Use of Deep Learning to Study Modeling Deterioration of Pavements a Case Study in Iowa

Infrastructures, 2020
This paper describes the process and outcome of deterioration modeling for three different pavement types (asphalt, concrete, and composite) in the state of Iowa.
Seyed Amirhossein Hosseini, Ahmad Alhasan, Omar Smadi   +2 more
doaj   +1 more source

Achieving High Accuracy Prediction of Minimotifs

PLoS ONE, 2012
The low complexity of minimotif patterns results in a high false-positive prediction rate, hampering protein function prediction. A multi-filter algorithm, trained and tested on a linear regression model, support vector machine model, and neural network model, using a large dataset of verified minimotifs, vastly improves minimotif prediction accuracy ...
Mi, Tian, Rajasekaran, Sanguthevar, Merlin, Jerlin Camilus, Gryk, Michael R., Schiller, Martin   +4 more
openaire   +5 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Genomic Selection for Weaning Weight in Alpine Merino Sheep Based on GWAS Prior Marker Information

Animals
This study aims to compare the accuracy of genomic estimated breeding values (GEBV) estimated using a genomic best linear unbiased prediction (GBLUP) method and GEBV estimates incorporating prior marker information from a genome-wide association study ...
Haifeng Wang, Chenglan Li, Jianye Li, Rui Zhang, Xuejiao An, Chao Yuan, Tingting Guo, Yaojing Yue   +7 more
doaj   +1 more source